Association between environmental tobacco smoke and diminished dendritic cell interleukin 10 production during infancy

Gentile, Deborah A.; Howe-Adams, Judith; Trecki, Jordan; Patel, A.; Angelini, Betty; Skoner, David P.

doi:10.1016/s1081-1206(10)61779-6

Cited by 18 publications

(7 citation statements)

References 40 publications

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“…Literature with regard to the impact of tobacco smoke on the production of IL‐10 is highly variable and cell‐specific. For example, in DCs cultured from peripheral blood mononuclear cells, ETS‐exposed infants demonstrated a decrease in IL‐10 compared with infants with no ETS exposure . In this study we found that, compared with NS‐HSNEC treatment, moDC IL‐10 was increased with CSE‐HSNEC‐conditioned media treatment.…”

Section: Discussionsupporting

confidence: 46%

Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells

Mulligan

O’Connell

Pasquini

et al. 2017

Int Forum Allergy Rhinol

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Background These studies examined the impact of environmental tobacco smoke (ETS) and active smoking on sinonasal dendritic cell (DCs) subsets in controls or patients with chronic rhinosinusitis with nasal polyps (CRSwNP). In subsequent in vitro investigations, we examined the influence of cigarette smoke extract (CSE) on human sinonasal epithelial cells’ (HSNECs) ability to regulate DC functions. Methods Sinonasal tissue, blood and hair were collected from patients undergoing sinus surgery. Smoking status and ETS exposure were determined by hair nicotine. DC subsets were examined by flow cytometric analysis. Monocyte-derived dendritic cells (moDCs) were treated with conditioned medium from non-smoked exposed HSNEC (NS-HSNEC) or cigarette smoke extract-exposed HSNEC (CSE-HSNEC) to assess the impact of CSE exposure on HSNEC regulation of moDCs functions. Results Control subjects who were active smokers displayed increased sinonasal moDC and mDC1 and reduced mDC2 cells, while in those with CRSwNP only moDC and mDC2 were altered. ETS was found to increase only moDCs in patients with CRSwNP. In vitro, CSE stimulated HSNEC secretion of the moDC regulatory products CCL20, PGE2 and GM-CSF. CSE-exposure also promoted HSNECs to stimulate monocyte and moDC migration. MoDCs treated with CSE-HSNEC media stimulated an increase in antigen uptake and expression of CD80 and CD86. Lastly, CSE-HSNEC treated moDCs secreted increased levels of IL-10, IFN-γ and TSLP compared Conclusions Active smoking and to a lesser degree ETS, alters the sinonasal composition of DCs. A potential mechanism to account for this is that cigarette smoke stimulates HSNEC to induce moDC migration, maturation and activation.

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Section: Discussionsupporting

confidence: 46%

Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells

Mulligan

O’Connell

Pasquini

et al. 2017

Int Forum Allergy Rhinol

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“…Evidence from both animal models and human epidemiologic research underscores the important role that prenatal stress plays in a broad range of fetal developmental outcomes (192). Environmental exposures may be some of the ''physical challenges'' that contribute to maternal immune stress given that several environmental contaminants including heavy metals, air pollution, and environmental tobacco smoke have been linked to alterations in the host inflammatory response (193)(194)(195)(196)(197)(198)(199)(200)(201). In addition, the stressors faced by African-American women as a marginalized group may directly compromise their physiologic functioning (172,(202)(203)(204) as well as encourage unhealthy behaviors as a coping mechanism for stress (148,205,206).…”

Section: Discussionmentioning

confidence: 99%

Environmental Contributions to Disparities in Pregnancy Outcomes

Miranda

Maxson²,

Edwards³

2009

Epidemiologic Reviews

107

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One of the most persistent disparities in American health status is the pronounced difference in birth outcomes between non-Hispanic black and non-Hispanic white women. Poor pregnancy outcomes have a substantial impact on mortality, morbidity, and health care costs. Increasing evidence indicates that environmental exposures are associated with poor birth outcomes. This paper reviews the latest research on how environmental exposures affect pregnancy outcomes and then discusses how these exposures may be embedded within a context of significant social and host factor stress. The analysis suggests that environmental, social, and host factors are cumulatively stressing non-Hispanic black women and that this cumulative stress may be a cause of the persistent disparities in pregnancy outcomes.

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“…Children regularly exposed to ETS have double the chance of having asthma in adulthood (9). Moreover, exposure to ETS has been shown to have an adjuvant effect on atopic dermatitis and allergic sensitization, especially in predisposed children (10), possibly by altering their cytokine profile (11, 12).…”

mentioning

confidence: 99%

Association of passive exposure of pregnant women to environmental tobacco smoke with asthma symptoms in children

Xepapadaki

Μanios

Liarigkovinos

et al. 2009

Pediatric Allergy Immunology

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Environmental tobacco smoke (ETS) is a significant risk factor for the presence and increased severity of asthma- and allergy-related symptoms in children. Smoking during pregnancy has detrimental effects on asthma-associated outcomes in childhood. Whether passive exposure of pregnant women to ETS may also lead to asthma in their offspring, is not known. The aim of this study was to investigate the association of passive exposure of pregnant women to ETS and asthma- and/or allergy-related symptoms in Preschool children. Cross-sectional data were collected with questionnaires from 2374 Preschool children, recruited from public and private nurseries and day-care centers. Parental smoking was significantly associated with wheezing symptoms in their children. Mother's active smoking during pregnancy significantly increased the risk for occurrence of asthma symptoms and/or medically diagnosed asthma in Preschool children in a dose-dependent manner. Passive exposure to ETS, mainly during the third trimester of pregnancy, was significantly associated with asthma- and allergy-related symptoms after adjusting for several confounders in a multivariate analysis (current wheeze: OR = 1.42, 95% CI = 1.06-1.91, pruritic rash ever: OR= 1.45, 95% CI = 1.01-2.08). Passive exposure of pregnant women to ETS during the third trimester is positively associated with asthma- and allergy-related symptoms in their Preschool age children. Public health policies should be oriented not only towards smoking cessation, but also reinforce elimination of ETS exposure of pregnant women.

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Association between environmental tobacco smoke and diminished dendritic cell interleukin 10 production during infancy

Cited by 18 publications

References 40 publications

Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells

Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells

Environmental Contributions to Disparities in Pregnancy Outcomes

Association of passive exposure of pregnant women to environmental tobacco smoke with asthma symptoms in children

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