Association between excess body weight and urine protein concentration in healthy dogs

Tefft, Karen M; Shaw, Darcy H.; Ihle, Sherri L.; Burton, Shelley A.; Pack, LeeAnn

doi:10.1111/vcp.12139

Cited by 12 publications

(13 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An obesity-related glomerulopathy is well described in human beings (Praga and Morales, 2006) and experimentally-induced obesity in dogs results in glomerular lesions (Henegar et al, 2001). However, a recent study did not find any relationship between obesity and proteinuria in client-owned dogs; 20 dogs were overweight or obese, and all had UPC values <0.2 (Tefft et al, 2014). Most of the dogs in this study had an ideal BCS, which could have hindered the ability to identify a relationship between obesity and HTG or proteinuria.…”

Section: Discussionmentioning

confidence: 94%

Proteinuria and lipoprotein lipase activity in Miniature Schnauzer dogs with and without hypertriglyceridemia

Furrow

Jaeger

Parker

et al. 2016

The Veterinary Journal

View full text Add to dashboard Cite

Spontaneous hyperlipidemia in rats causes glomerular disease. Idiopathic hypertriglyceridemia (HTG) is prevalent in Miniature schnauzers, but its relationship with proteinuria is unknown. Decreased activity of major lipid metabolism enzymes, lipoprotein lipase (LPL) and hepatic lipase (HL), may play a role in the cyclic relationship between hyperlipidemia and proteinuria. These enzymes have also not been previously investigated in Miniature shnauzers. The aims of this study were to determine the relationship between HTG and proteinuria in Miniature schnauzers and to measure LPL and HL activities in a subset of dogs. Fifty-seven Miniature schnauzers were recruited (34 with and 23 without HTG). Fasting serum triglyceride concentrations and urine protein-to-creatinine ratios (UPC) were measured in all dogs, and LPL and HL activities were determined in 17 dogs (8 with and 9 without HTG). There was a strong positive correlation between triglyceride concentration and UPC (r = 0.77–0.83, P < 0.001). Proteinuria (UPC ≥ 0.5) was present in 60% of dogs with HTG and absent from all dogs without HTG (P < 0.001). Proteinuric dogs were not azotemic or hypoalbuminemic. Dogs with HTG had a 65% reduction in LPL activity relative to dogs without HTG (P < 0.001); HL activity did not differ. Proteinuria occurs with HTG in Miniature schnauzers and could be due to lipid-induced glomerular injury. Reduced LPL activity may contribute to the severity of HTG, but further assay validation is required.

show abstract

Section: Discussionmentioning

confidence: 94%

Proteinuria and lipoprotein lipase activity in Miniature Schnauzer dogs with and without hypertriglyceridemia

Furrow

Jaeger

Parker

et al. 2016

The Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…A recent study on 20 overweight/obese dogs and 22 ideal bodyweight control dogs found no effect of obesity on the level of proteinuria/microalbuminuria, concluding that clinicopathological abnormalities consistent with obesity-related glomerulopathy are absent. 34 However, this contrasts with the significant reduction in proteinuria seen after weight loss in dogs with naturally occurring obesity. 35 Larger scale studies, including renal biopsies, are necessary to further assess the effect of canine obesity on proteinuria.…”

Section: Discussionmentioning

confidence: 95%

“…Because of the small sample size, the effect of BCS on proteinuria in dogs could not be evaluated. A recent study on 20 overweight/obese dogs and 22 ideal bodyweight control dogs found no effect of obesity on the level of proteinuria/microalbuminuria, concluding that clinicopathological abnormalities consistent with obesity‐related glomerulopathy are absent . However, this contrasts with the significant reduction in proteinuria seen after weight loss in dogs with naturally occurring obesity .…”

Section: Discussionmentioning

confidence: 95%

Proteinuria in Apparently Healthy Elderly Dogs: Persistency and Comparison Between Free Catch and Cystocentesis Urine

Marynissen

Willems

Paepe

et al. 2016

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundUp to 25% of elderly humans have proteinuria, often associated with underlying lesions. Data concerning the presence of proteinuria in elderly dogs is scarce.ObjectivesTo describe the presence and persistence of proteinuria and to compare urinary protein : creatinine ratio (UPC) between free catch and cystocentesis urine samples in apparently healthy elderly dogs.AnimalsHundred apparently healthy elderly dogs.MethodsProspective study. Owners of 100 elderly dogs were asked to collect 2 free catch urine samples. Dogs were considered healthy based on owner's perception and an age chart, based on ideal bodyweight, was used to define dogs as senior or geriatric. UPC of urine collected by free catch and cystocentesis were compared. Overt proteinuria and borderline proteinuria were defined as UPC >0.5 and between 0.2 and 0.5, respectively, if examination of sediment did not explain proteinuria. Proteinuria was considered persistent if present at both sampling times.ResultsAt baseline, 71 owners succeeded in collecting urine. Eleven percent of dogs had overt proteinuria, 14% were borderline proteinuric, and 75% nonproteinuric. Thirty‐seven repeated urine samples, with a median time interval of 31 days (range 10–90), were available. Nineteen percent of dogs had a persistently increased UPC (>0.2), with persistent overt proteinuria present in 8%. A strong correlation (ρ = 0.88) was found between UPC of urine collected by free catch and cystocentesis.Conclusions and Clinical ImportanceAs 19% of study dogs had persistent proteinuria, our findings emphasize that measurement of proteinuria should be part of geriatric health screening. For UPC in dogs, free catch urine provides a good alternative to cystocentesis.

show abstract

“…Glomerular lesions have been reported with experimentally induced obesity in dogs, but urinary protein concentration was not quantified for the dogs. In a study that included 6 obese (BCS, 8–9 of 9) client‐owned dogs, none had an increased UPC . Further studies evaluating the relationship between obesity and HTG should be performed to determine whether improved BCS influences the severity of proteinuria seen in markedly obese dogs.…”

Section: Discussionmentioning

confidence: 99%

Clinical Consequences of Hypertriglyceridemia‐Associated Proteinuria in Miniature Schnauzers

Smith

Granick

Stauthammer

et al. 2017

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundPrimary hypertriglyceridemia is a common condition in older Miniature Schnauzers that recently has been associated with proteinuria and underlying glomerular pathology, particularly glomerular lipid thromboemboli. Consequences of glomerular disease can include hypertension, thromboembolic disease, and cardiac disease. The incidence of these sequelae in Miniature Schnauzers with hypertriglyceridemia‐associated proteinuria (HTGP) is unknown.ObjectiveTo investigate prevalence of hypertension, decreased antithrombin III activity, and cardiac disease in Miniature Schnauzers with and without HTGP.AnimalsThirty‐two Miniature Schnauzers ≥7 years old.MethodsProspective case‐control study. Data collected from dogs included a CBC, biochemistry panel, urinalysis, urine protein‐to‐creatinine ratio, urine cortisol‐to‐creatinine ratio, serum total thyroxine concentration, fasting serum triglyceride concentration, indirect blood pressure, antithrombin III activity, and serum cardiac troponin I concentration. Results from dogs with HTGP (serum triglyceride concentration ≥ 100 mg/dL and urine protein‐to‐creatinine ratio >0.5) were statistically compared to normotriglyceridemic, nonproteinuric dogs.ResultsEighteen of the 32 dogs (56%) had primary hypertriglyceridemia. Of those dogs, 8 of 18 had proteinuria. None of the HTGP dogs were azotemic or hypoalbuminemic. Serum albumin concentration, alkaline phosphatase activity, and cholesterol concentration were significantly increased in dogs with HGTP compared to those without HGTP. No increased risk of hypertension, decreased antithrombin III activity, or cardiac disease was noted. Limited data from 8 dogs with HTGP showed no development of hypoalbuminemia or azotemia over a median follow‐up period of 18 months.Conclusions and Clinical ImportanceGeriatric Miniature Schnauzers with HGTP may have a good prognosis overall, and are not typically azotemic or hypoalbuminemic.

show abstract

Association between excess body weight and urine protein concentration in healthy dogs

Abstract: Clinicopathologic abnormalities consistent with ORG were absent from overweight/obese dogs in this study.

Cited by 12 publications

References 14 publications

Proteinuria and lipoprotein lipase activity in Miniature Schnauzer dogs with and without hypertriglyceridemia

Proteinuria and lipoprotein lipase activity in Miniature Schnauzer dogs with and without hypertriglyceridemia

Proteinuria in Apparently Healthy Elderly Dogs: Persistency and Comparison Between Free Catch and Cystocentesis Urine

Clinical Consequences of Hypertriglyceridemia‐Associated Proteinuria in Miniature Schnauzers

Contact Info

Product

Resources

About