Association between FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphism and breast cancer susceptibility: a meta-analysis

Abstract

The association between fibroblast growth factor receptor 2 (FGFR2) polymorphism and breast cancer (BC) susceptibility remains inconclusive. The purpose of this systematic review was to evaluate the relationship between FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphism and BC risk. PubMed, Web of science and the Cochrane Library databases were searched before October 11, 2015 to identify relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of associations. Sensitivity and subgroup analyses were conducted. Thirty-five studies published from 2007 to 2015 were included in this meta-analysis. The pooled results showed that there was significant association between all the 3 variants and BC risk in any genetic model. Subgroup analysis was performed on rs2981582 and rs2420946 by ethnicity and Source of controls, the effects remained in Asians, Caucasians, population-based and hospital-based groups. We did not carryout subgroup analysis on rs2981578 for the variant included only 3 articles. This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk. For rs2981582 and rs2420946, the association remained significant in Asians, Caucasians, general populations and hospital populations. However, further large scale multicenter epidemiological studies are warranted to confirm this finding and the molecular mechanism for the association need to be elucidated further.

MassARRAY-based single nucleotide polymorphism analysis in breast cancer of north Indian population

“…The variant rs664677 in the DNA damage response gene ATM though not associated in our population, previously has been reported to be associated with breast cancer and lung cancer risk in Asian people [24]. Another variant rs2981582, in the FGFR2 gene, which was not associated in the population under study, was found associated with breast cancer in Asian and Caucasian population groups [25]. The gene SLC4A7 having the rs4973768 although not significantly associated with breast cancer in our population previously has been found associated with increased risk of breast cancer in Chinese population [26].…”

WITHDRAWN: The epigenetic study of Fgfr2 as a potential biomarker in the differential diagnosis of intestinal metaplasia and gastric cancer

“…The high expressed levels of FGFR2 in colorectal [13], lung [14], gastric [15][16][17] cancer, coding mutations [18], and more recently, FGFR fusions that lead to pathway activation [19] have been demonstrated that the FGFR2 has a signi cant oncogenic potential across multiple cancer types. ROC analysis was employed to compare the predictive accuracy of the methylation status of patients with gastric cancer.…”

Effects of FGFR gene polymorphisms on response and toxicity of cyclophosphamide-epirubicin-docetaxel-based chemotherapy in breast cancer patients

“…Recently, lots of studies have reported the association between rs2981578, rs2981579 and breast cancer risk in any genetic model [ 49 ]. For rs2981578, Chen et al [ 37 ] revealed that rs2981578 are associated with a decreased risk of breast cancer, which is contrary to the previous reports [ 35 , 50 ], indicating that the difference of the associations is due to different minor alleles among different ethnicities.…”