Association between fish intake and glioma risk: a systematic review and meta-analysis

Abstract

Objectives We investigated the association between the consumption of fresh and processed fish and glioma risk using a meta-analysis approach. Methods We selected and analyzed observational studies that discussed the relationships between fresh and processed fish intake on glioma risk from PubMed, Web of Science, Embase, and the SinoMed and Wanfang databases from inception to 31 March 2020. Studies were selected according to pre-established eligibility criteria and data were extracted separately by two researchers. A meta-analysis was conducted based on a random-effects model to provide pooled odds ratios (OR) and 95% confidence intervals (CIs). Results Eight studies considered the relationship between fish intake (seven fresh and seven processed fish) and glioma risk and were included in this meta-analysis. The OR effect size for fresh fish intake and glioma risk was 0.72 (95%CI 0.53–0.97) and the overall OR effect size for processed fish intake and glioma risk was 1.88 (95%CI 1.06–3.34). Conclusion Dietary intake of fresh fish may reduce the risk of glioma, but consumption of processed fish may increase the risk of glioma. This study had some limitations, and further studies are therefore required to clarify the associations between fish intake and glioma risk.

Healthy dietary patterns, foods, and risk of glioma: A systematic review and meta-analysis of observational studies

“…For example, a previous metaanalysis of eight observational studies, reporting the association between dietary fresh fish and processed fish intake and the risk of glioma, revealed that higher intake of fresh fish could significantly reduce the risk of glioma (RR = 0.823, 95% CI: 0.698-0.970) (68). Significant inverse association was also found in another meta-analysis by Lei et al (56). Lei et al's study found that compared with the lowest category, the highest category of fresh fish intake was significantly associated with a reduced risk of glioma (OR = 0.72; 95% CI: 0.53-0.97; P = 0.032).…”

“…Experimental studies have shown that above these compounds result in cell cycle arrest, and promote anti-tumor efficacies of lomustine in glioblastoma cells ( 54 , 55 ). A recent meta-analysis examining the association of fish intake with glioma also concluded that higher consumption of fresh fish was associated with a reduced risk of glioma ( 56 ). Finally, vegetables, fruits and whole grains also contain large amounts of dietary fiber.…”

“…Although several previous meta-analyses have discussed the effect of fish intake on glioma risk ( 8 , 56 , 68 ), unfortunately, the results have been inconclusive. For example, a previous meta-analysis of eight observational studies, reporting the association between dietary fresh fish and processed fish intake and the risk of glioma, revealed that higher intake of fresh fish could significantly reduce the risk of glioma (RR = 0.823, 95% CI: 0.698–0.970) ( 68 ).…”

“…The number of articles was relatively small, and only four articles (reporting five studies) published in English were included in this meta-analysis, which might omit other languages studies. What is more, we excluded three studies that had been included in previous meta-analyses ( 56 , 68 ) but involved meningiomas and other types of brain tumors. Second, all the included studies were case-control studies, which might be subject to recall and selection biases.…”

Fish consumption in multiple health outcomes: an umbrella review of meta-analyses of observational and clinical studies

“…The association between fish consumption and mortality is presented in Table 1 (19)(20)(21)(22)(23)(24)(25)(26)(27). Table 2 (14,22,(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45) presents the associations between consumption of fish and cancer outcomes (46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64), while those between fish consumption and CVD are presented Table…”