Association between Functional Dyspepsia and Gastric Depressive Erosions in Japanese Subjects

Tanaka, Fumio; Tominaga, Kazunari; Fujikawa, Yoshiko; Morisaki, Tamami; Otani, Koji; Hosomi, Shuhei; Nagami, Yasuaki; Kamata, Noriko; Taira, Koichi; Nakano, Akemi; Kimura, Tooru; Yamagami, Hirokazu; Tanigawa, Tetsuya; Morikawa, Hiroyasu; Fukumoto, Shinya; Watanabe, Toshio; Kawada, Norifumi; Hirata, Kazuto; Fujiwara, Yasuhiro

doi:10.2169/internalmedicine.1325-18

Cited by 11 publications

(12 citation statements)

References 35 publications

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“…Some data indicate that there is a clear relation of symptoms and H. pylori gastritis: many dyspeptic symptoms are more prevalent and more intense in the H. pylori -positive population [ 17 , 18 ]. Other data do not support these findings [ 19 ].…”

Section: Introductionmentioning

confidence: 89%

Changes in the Seroprevalence of Helicobacter pylori among the Lithuanian Medical Students over the Last 25 Years and Its Relation to Dyspeptic Symptoms

et al. 2021

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Background and Objectives: The prevalence of Helicobacter pylori infection is decreasing in the Western world, while remaining high in developing countries. There is limited up-to-date information about the prevalence of H. pylori in Central and Eastern Europe. The aim of our study was to assess the seroprevalence of H. pylori and its trend over the past 25 years among students of the Lithuanian University of Health Sciences (LUHS) and to assess its relation to dyspeptic symptoms. Materials and Methods: In the years 1995, 2012, 2016 and 2020, students from Medical and Nursing Faculties of LUHS were tested for the presence of antibodies against H. pylori by performing serological tests from finger capillary blood. In addition, in the years 2012, 2016 and 2020, the students completed a gastrointestinal symptom rating scale (GSRS) questionnaire in order to assess dyspeptic symptoms. The study population consisted of 120 students in the year 1995 (mean age—21.3 ± 1.0 years), 187 students in the year 2012 (mean age—22.4 ± 0.7 years), 262 students in the year 2016 (mean age—20.4 ± 1.0 years) and 148 students in the year 2020 (mean age—20.4 ± 1.7 years). Results: The seroprevalence for H. pylori was positive in 62 (51.7%) students in 1995, in 57 (30.4%) students in 2012, in 69 (26.3%) students in 2016 and in 21 (14.2%) students in 2020. The statistically significant difference was found between all study years, except between 2012 and 2016. There were no significant differences in frequency and intensity of upper dyspeptic symptoms between H. pylori positive and negative students. Conclusions: Over the last 25 years the seroprevalence of H. pylori among students of LUHS has decreased significantly. No consistent differences in dyspeptic symptoms among H. pylori positive and negative subgroups were found.

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Section: Introductionmentioning

confidence: 89%

Changes in the Seroprevalence of Helicobacter pylori among the Lithuanian Medical Students over the Last 25 Years and Its Relation to Dyspeptic Symptoms

et al. 2021

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“…Severity of gastritis was evaluated using the Kyoto classification [ 29 , 30 ]. Barrett’s esophagus was diagnosed endoscopically if columnar-appearing mucosa was observed between the squamocolumnar and EG junction.…”

Section: Methodsmentioning

confidence: 99%

Risk of Reflux-Related Symptoms and Reflux Esophagitis after Helicobacter pylori Eradication Treatment in the Japanese Population

Sugimoto

Murata

Iwata

et al. 2021

JCM

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Backgrounds: A meta-analysis of reports primarily from Western countries showed no association between Helicobacter pylori eradication and reflux esophagitis development. The risk of reflux esophagitis may differ among different populations based on H. pylori virulence factors and acid secretion ability. We evaluated the prevalence rates of reflux esophagitis in H.-pylori-positive Japanese subjects and assessed risk factors for reflux esophagitis after eradication. Methods: Among 148 H.-pylori-positive subjects who underwent H. pylori eradication from August 2015 to December 2019, we evaluated the prevalence of reflux esophagitis on endoscopy at 12 months after eradication success and the severity of reflux-related symptoms by the F-scale questionnaire at 2 months after treatment and 12 months after eradication success. Results: The prevalence of reflux esophagitis in H.-pylori-positive patients at entry was 2.0% (3/148). At 12 months after eradication success, the prevalence was 10.8% (16/148) (p < 0.01). In the F scale, the median total score before treatment was 4 (range: 0–49), which significantly decreased to 2 (range: 0–22) (p < 0.01) at 2 months after treatment and 3 (range: 0–23) (p < 0.01) at 12 months after eradication success. Following multivariate analysis, the pretreatment total F-scale score was a risk factor for the development of reflux esophagitis (odds ratio: 1.069, 95% confidence interval: 1.003–1.139, p < 0.01). Conclusions: In this H.-pylori-positive Japanese population, eradication therapy was associated with reflux esophagitis in around 10% of patients, particularly in those with severe reflux-related symptoms at baseline. Reflux-related symptoms may improve throughout the 12 months after successful eradication therapy, irrespective of the development of reflux esophagitis.

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“…We considered the results as false-negative for anti-HP antibody when subjects demonstrated endoscopic findings compatible with those of current HP infections and with antibody values < 10 U/mL. Endoscopic findings of HP infection were diagnosed according to the Kyoto classification of gastritis [22]. The findings of current HP infections were as follows: diffuse redness, enlarged fold, nodularity, mucosal swelling, sticky mucus, and gastric atrophy.…”

Section: Diagnosis Of Hp Statusmentioning

confidence: 99%

Exosomal hsa-miR-933 in Gastric Juice as a Potential Biomarker for Functional Dyspepsia

et al. 2020

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Background: MicroRNAs (miRNAs) in exosomes represent disease-specific profiles, and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role of exosomal miRNAs has not been fully elucidated. Aims: To investigate exosomal miRNAs as potential biomarkers of FD using liquid biopsy. Methods: This retrospective cohort study included 11 subjects with FD and 11 age-and sexmatched healthy controls (HCs). We collected gastric juice and isolated exosomal miRNAs. In a discovery cohort, expression levels of 2,565 miRNAs were evaluated by 3D-Gene ® microarray. miRNA expression profiles from exosomes of subjects with FD and HCs were compared by two normalization methods: (1) global normalization and (2) normalization by internal control. Subsequently, in a validation cohort, the expression levels of miRNAs were validated by quantitative reverse transcription PCR (RT-qPCR). Results: Through microarray analysis using the two methods, we identified 39 miRNAs that were consistently and significantly downregulated in FD cases compared with those in HCs. Of these, 12 miRNAs (hsa-miR-933,-345-5p,-708-5p,-203a-3p,-619-5p,-4294,-4481,-196a-5p,-3918,-372-3p,-658, and-3654) were further validated by RT-qPCR. Our results indicated that hsa-miR-933 was significantly downregulated in FD compared with HCs (0.317 ± 0.205-fold, P = 0.0317). Furthermore, the expression level of hsa-miR-933 was negatively associated with dyspepsia score and the frequency of epigastric pain and/or burning (P < 0.01, r = −0.835; P = 0.0280, r = −0.688, respectively). Conclusions: Exosomal hsa-miR-933 in gastric juice could be a candidate biomarker for FD.

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Association between Functional Dyspepsia and Gastric Depressive Erosions in Japanese Subjects

Cited by 11 publications

References 35 publications

Changes in the Seroprevalence of Helicobacter pylori among the Lithuanian Medical Students over the Last 25 Years and Its Relation to Dyspeptic Symptoms

Changes in the Seroprevalence of Helicobacter pylori among the Lithuanian Medical Students over the Last 25 Years and Its Relation to Dyspeptic Symptoms

Risk of Reflux-Related Symptoms and Reflux Esophagitis after Helicobacter pylori Eradication Treatment in the Japanese Population

Exosomal hsa-miR-933 in Gastric Juice as a Potential Biomarker for Functional Dyspepsia

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