Association between gastric Candida colonization and surgical site infections after high-level hepatobiliary pancreatic surgeries: the results of prospective observational study

Gyoten, Kazuyuki; Kato, Hiroyuki; Hayasaki, Aoi; Fujii, Takehiro; Iizawa, Yusuke; Murata, Yasuhiro; Tanemura, Akihiro; Kuriyama, Naohisa; Kishiwada, Masashi; Mizuno, Shugo; Usui, Masanobu; Sakurai, Hiroyuki; Isaji, Shuji

doi:10.1007/s00423-020-02006-7

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…A study on high-level hepato-biliary-pancreatic surgery demonstrated a relationship between the colonization of the gastric juice by Candida spp. and postoperative SSI [22]. In that study, colonization of the gastric juice by Candida spp.…”

Section: Discussionmentioning

confidence: 88%

Colonization of the gastric juice by Candida spp. promotes surgical site infection after hepatectomy

Iida

Kaibori

Maehira

et al. 2023

Langenbecks Arch Surg

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Purpose: Candida spp. cause opportunistic infections in conditions of immunode ciency. Here, we investigated the relationship between colonization of the gastric juice by Candida spp. and surgical site infection (SSI) in hepatectomy.Methods: Consecutive hepatectomy cases between November 2019 and April 2021 were enrolled. Gastric juice samples (collected intraoperatively through a nasogastric tube) were cultured. We compared factors related to patient background, blood test ndings, surgical ndings, and postoperative complications between the Candida+group (positive for colonization of the gastric juice by Candida spp.) and the Candidagroup (negative). In addition, we identi ed the factors that contribute to SSI.Results: There were 29 and 71 patients in the Candida+ and Candidagroups, respectively. The Candida+ group was signi cantly older (average age: Candida+ 74 years vs. Candida-69 years; p=0.02) and contained more patients who were negative for the hepatitis B and C virus (Candida+ 93% vs. Candida-69%; p=0.02). SSI was signi cantly more common in the Candida+ group (Candida+ 31% vs. Candida-9%; p=0.01). Postoperative bile leakage and colonization of the gastric juice by Candida spp. were independent predictors of SSI.Conclusion: Colonization of the gastric juice by Candida spp. is a risk factor for SSI after hepatectomy.

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Section: Discussionmentioning

confidence: 88%

Colonization of the gastric juice by Candida spp. promotes surgical site infection after hepatectomy

Iida

Kaibori

Maehira

et al. 2023

Langenbecks Arch Surg

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show abstract

“…We routinely used cefmetazole, which had the antimicrobial coverage of Klebsiella species, in contrast to first-generation cephalosporin. In addition to bacterial pathogens, some articles addressed that Candida species in bile were a significant factor in developing IAA [ 29 , 30 ]. It was considered that the fungal infection process not only caused physical damage to organ walls, allowing other microorganisms to penetrate more easily, but also directly stimulated the bacterial growth (synergetic ability of fungal–bacterial coinfection) [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Specific Bile Microorganisms Caused by Intra-Abdominal Abscess on Pancreaticoduodenectomy Patients: A Retrospective Cohort Study

Lin

et al. 2021

Current Oncology

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We retrospectively collected PD patients with a performance of bile culture between 2007 and 2019 in our institute. As to bile culture, we used a swab to do intraoperative bile cultures after transection of the CBD. IAA was defined as the documental bacteriological culture from either a turbid discharge from the intraoperatively placed drain in patients with a clinical picture consistent with infection or a postoperative fluid collection managed by CT-guided placement of drains. A total of 1244 PD patients were identified, and 539 (43.3%) subjects with bile sampling were included for analysis. Among these study patients, 433 (80.3%) developed bile contamination (positive bile culture). Bile contamination showed a significantly higher rate of IAA compared to non-bile contamination (17.1% vs. 0.9%, p < 0.001). The rate of co-shared microorganisms in both bile and abscess was 64.1%. On the multivariate analysis, age and specific bile microorganisms (Enterococcus species, Escherichia Coli, Streptococcus species, Citrobacter species, and Candida) are significantly associated with development of IAA. Specific bile microorganisms are the highly significant factors associated with development of IAA. The strategy to prevent bile spillage during PD should be considered to minimize afterward contamination of the abdominal cavity and prevent IAA.

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Colonization of the gastric juice by Candida spp. promotes surgical site infection after hepatectomy

Iida

Kaibori

Maehira

et al. 2023

Preprint

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Purpose: Candida spp. cause opportunistic infections in conditions of immunodeficiency. Here, we investigated the relationship between colonization of the gastric juice by Candida spp. and surgical site infection (SSI) in hepatectomy. Methods: Consecutive hepatectomy cases between November 2019 and April 2021 were enrolled. Gastric juice samples (collected intraoperatively through a nasogastric tube) were cultured. We compared factors related to patient background, blood test findings, surgical findings, and postoperative complications between the Candida+group (positive for colonization of the gastric juice by Candida spp.) and the Candida- group (negative). In addition, we identified the factors that contribute to SSI. Results: There were 29 and 71 patients in the Candida+ and Candida- groups, respectively. The Candida+ group was significantly older (average age: Candida+ 74 years vs. Candida- 69 years; p=0.02) and contained more patients who were negative for the hepatitis B and C virus (Candida+ 93% vs. Candida- 69%; p=0.02). SSI was significantly more common in the Candida+ group (Candida+ 31% vs. Candida- 9%; p=0.01). Postoperative bile leakage and colonization of the gastric juice by Candida spp. were independent predictors of SSI. Conclusion: Colonization of the gastric juice by Candida spp. is a risk factor for SSI after hepatectomy.

show abstract

Association between gastric Candida colonization and surgical site infections after high-level hepatobiliary pancreatic surgeries: the results of prospective observational study

Cited by 3 publications

References 38 publications

Colonization of the gastric juice by Candida spp. promotes surgical site infection after hepatectomy

Colonization of the gastric juice by Candida spp. promotes surgical site infection after hepatectomy

Specific Bile Microorganisms Caused by Intra-Abdominal Abscess on Pancreaticoduodenectomy Patients: A Retrospective Cohort Study

Colonization of the gastric juice by Candida spp. promotes surgical site infection after hepatectomy

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