Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis

Nowrin, Shifat A; Jaafar, Saidi; Rahman, Norma Ab; Alam, Mohammad Khursheed; Shahid, Fazal

doi:10.4041/kjod.2018.48.6.395

Cited by 23 publications

(10 citation statements)

References 31 publications

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“…In addition, it is important to consider that the inherent characteristics of each study population may interfere with the EARR process, since differences in the frequency of EARR as well as in the risk factors associated with EARR among populations have already been described in the literature 8. Recent studies also reported a genetic predisposition that may explain why one patient is more likely to develop EARR during orthodontic treatment than does another2829; therefore, individual variability should also be considered, even though it has not been evaluated in the present study.…”

Section: Discussionmentioning

confidence: 99%

Predisposing factors for external apical root resorption associated with orthodontic treatment

et al. 2019

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ObjectiveThis study aimed to identify possible risk factors for external apical root resorption (EARR) in the maxillary incisors after orthodontic treatment.MethodsThe root length of 2,173 maxillary incisors was measured on periapical radiographs of 564 patients who received orthodontic treatment. The Kappa test was performed to evaluate intraexaminer and interexaminer reproducibility. Multiple binary logistic regression was used to determine the association between EARR and various factors. Odds ratios and 95% confidence intervals were reported.ResultsThe risk of developing EARR was 70% higher in orthodontic treatment with maxillary premolar extraction (p = 0.004), 58% higher in patients with increased overjet (p = 0.012), 41% lower in two-phase orthodontic treatment (p = 0.037), and 33% lower in patients with deep bite (p = 0.039). The lateral incisors were 54% more likely to develop EARR (p < 0.001), dilacerated roots were 2.26 times more likely to develop EARR (p < 0.001), and for each additional millimeter of root length, the risk of EARR increased by 29% (p < 0.001).ConclusionsThe potential risk factors for EARR after orthodontic treatment included treatment with maxillary premolar extraction, increased overjet at the beginning of treatment, and dilacerated roots.

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Section: Discussionmentioning

confidence: 99%

Predisposing factors for external apical root resorption associated with orthodontic treatment

et al. 2019

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“… 2 However, a recent meta-analysis suggested that the IL-1β polymorphism is not correlated with a predilection to EARR. 3 Earlier literature showed that the incidence and severity of root resorption was connected with numerous mechanical factors, including force magnitude, the amount or distance of tooth movement, force type, and treatment appliance. 4 , 5 Increased treatment time or prolonged treatment duration positively correlated with increased EARR 4 ; thus, shortening the treatment duration is a worthwhile goal as it could decrease the risk of EARR.…”

Section: Introductionmentioning

confidence: 99%

Effect of micro-osteoperforations on external apical root resorption: A randomized controlled trial

2021

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Objective This study aimed to investigate the effect of micro-osteoperforations (MOPs) on external apical root resorption (EARR) during the initial orthodontic alignment phase of maxillary anterior crowding. Methods Thirty patients (25 females, 5 males; mean age, 22.66 ± 3.27 years) who presented with moderate crowding of the upper labial segment and underwent extraction-based fixed appliance treatment were recruited. They were randomly allocated to receive adjunctive therapy with MOPs (n = 15) or treatment with fixed appliances only (control group; n = 15). EARR was measured from long-cone periapical radiographs taken at the start and the sixth month of treatment. A correction factor for the enlargement difference was used to calculate EARR. Data were analyzed with descriptive statistics and repeated-measures analysis of variance. Results The mean root lengths of 168 teeth were measured and showed no statistically significant difference ( p > 0.05) after six months of fixed appliance treatment in the MOP (mean difference [MD] = 0.13 mm; 95% confidence interval [CI] = −0.10–0.35) and control group (MD = 0.14 mm; 95% CI = −0.10–0.37). Most of the roots in the MOP and control groups (42.86% and 52.38%, respectively) showed only mild resorption. Less than 8% of the roots in both groups (7.14% in the MOP group and 4.76% in the control group) showed moderate resorption. Conclusions Acceleration of orthodontic tooth movement with adjunctive MOPs therapy during the alignment phase does not exacerbate EARR in patients with moderate crowding of the upper labial segment in comparison with controls.

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“…Orthodontically induced root resorption (OIRR) is a frequent iatrogenic effect of orthodontic intervention (Abass et al, 2008; Hartsfield, Everett, & Al‐Qawasmi, 2004). In this process, undesirable activities of specific resorptive cells on the root surface result in resorption of cementum and dentin (Nowrin et al, 2018; Weltman, Vig, Fields, Shanker, & Kaizar, 2010). If handled improperly, OIRR may compromise treatment outcome and even the longevity of the tooth.…”

Section: Introductionmentioning

confidence: 99%

Intermittent parathyroid hormone promotes cementogenesis via ephrinB2‐EPHB4 forward signaling

Wang

et al. 2020

Journal Cellular Physiology

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Intermittent parathyroid hormone (PTH) promotes periodontal repair, but the underlying mechanisms remained unclear. Recent studies found that ephrinB2-EPHB4 forward signaling mediated the anabolic effect of PTH in bone homeostasis. Considering the similarities between cementum and bone, we aimed to examine the therapeutic effect of PTH on resorbed roots and explore the role of forward signaling in this process. In vivo experiments showed that intermittent PTH significantly accelerated the regeneration of root resorption and promoted expression of EPHB4 and ephrinB2. When the signaling was blocked, the resorption repair was also delayed. In vitro studies showed that intermittent PTH promoted the expression of EPHB4 and ephrinB2 in OCCM-30 cells. The effects of PTH on the mineralization capacity of OCCM-30 cells was mediated through the ephrinB2-EPHB4 forward signaling. These results support the premise that the anabolic effects of intermittent PTH on the regeneration of root resorption is via the ephrinB2-EPHB4 forward signaling pathway.

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Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis

Cited by 23 publications

References 31 publications

Predisposing factors for external apical root resorption associated with orthodontic treatment

Predisposing factors for external apical root resorption associated with orthodontic treatment

Effect of micro-osteoperforations on external apical root resorption: A randomized controlled trial

Intermittent parathyroid hormone promotes cementogenesis via ephrinB2‐EPHB4 forward signaling

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