Association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study

Dou, Henri; Wang, Yuan‐Yuan; Yang, Nan; Mingli, Heng; Zhou, Xuan; Bu, Huaien; Xu, Fang; Tieniu, Zhao; Huang, He; Wang, Hongwu

doi:10.1007/s11655-015-2290-3

Cited by 12 publications

(5 citation statements)

References 26 publications

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“…In 2010, Xu et al 42 reported an association of this SNP with T2DM in a Chinese population, which is similar with the results in other populations. [25][26][27][28]33 However, Dou et al 43 found there is no association between this SNP and T2DM in another Chinese population, which is consistent with the results in other populations. 28,39,44 In the current study, we also did not find an association between this SNP and T2DM in the Chinese population.…”

Section: Discussionsupporting

confidence: 75%

Association Between Single Nucleotide Polymorphisms in CDKAL1 and HHEX and Type 2 Diabetes in Chinese Population

Li¹,

Shen²,

Yang³

et al. 2021

DMSO

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Type 2 diabetes mellitus (T2DM) has a high global prevalence, and the interaction of environmental factors and genetic factors may contribute to the risk of T2DM. We aimed to investigate the association between T2DM and the single nucleotide polymorphisms (SNPs) in genes (CDKAL1 and HHEX) associated with insulin secretion. Subjects and Methods: T2DM (n=1,169) and nondiabetic (NDM) (n=1,277) subjects were enrolled and the eight SNPs in CDKAL1 and HHEX genes associated with insulin secretion were genotyped in a Chinese population using MassARRAY. Then, the association of these SNPs with T2DM was analyzed. Results: Our results revealed that four SNPs (rs4712524, rs10946398, rs7754840 in CDKAL1, and rs5015480 in HHEX) showed significantly different distributions between the T2DM and NDM groups (P<0.00625). The G allele of rs4712524 (P=0.004, OR=1.184; 95% CI=1.057-1.327), C allele of rs10946398 (P<0.001, OR=1.247; 95% CI=1.112-1.398), and C allele of rs775480 in CDKAL1 (P<0.001, OR=1.229; 95% CI=1.096-1.387) functioned as risk alleles of T2DM. The C allele of rs5015480 in HHEX (P<0.001, OR=1.295; 95% CI=1.124-1.493) was also the risk factor for T2DM. The haplotype analysis revealed that CDKAL1 haplotype rs4712524G-rs10946398C-rs7754840C-rs9460546G (P=0.001, OR=1.210; 95% CI=1.076-1.360) and HHEX haplotype rs1111875C-rs5015480C (P<0.001, OR=1.364; 95% CI=1.180-1.576) were the risk factors of T2DM. Conclusion:Our results revealed that genetic variations in CDKAL1 and HHEX were associated with T2DM susceptibility in Chinese population.

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Section: Discussionsupporting

confidence: 75%

Association Between Single Nucleotide Polymorphisms in CDKAL1 and HHEX and Type 2 Diabetes in Chinese Population

Li¹,

Shen²,

Yang³

et al. 2021

DMSO

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“…This finding has been replicated in Danes (Boesgaard et al 2010), Chinese , Liu et al 2011, Dou et al 2016 and South Asians (Rees et al 2011), with a borderline association with T2D in a Japanese population (Fujita et al 2012). Furthermore, the glucose-raising allele GLIS3 rs7034200 A was also strongly associated with impaired β-cell function both in non-diabetic adults (Dupuis et al 2010, Hong et al 2014 as well as in healthy children and adolescents (Barker et al 2011), which suggests an age-independent effect of this locus on inter-individual differences in glucose levels from childhood onward.…”

Section: Glis3 and Type 2 Diabetesmentioning

confidence: 75%

“…During the secondary transition, endocrine hormone-expressing cells are rapidly expanded in the developing pancreas starting from E13.5 (Oliver- Krasinski & Stoffers 2008, Shih et al 2013. GLIS3 is predominantly expressed in the pancreas, thyroid and kidney, with modest expression in the heart, Dou et al (2016) Figure 1 Schematic diagrams of mouse and human GLIS3 gene and protein structures. (A) Mouse Glis3 gene and protein structures.…”

Section: The Temporal and Spatial Expression Of Glis3 In Mouse Pancreasmentioning

confidence: 99%

Emerging roles of GLIS3 in neonatal diabetes, type 1 and type 2 diabetes

Wen

Yang

2017

Journal of Molecular Endocrinology

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GLI-similar 3 (GLIS3), a member of the Krüppel-like zinc finger protein subfamily, is predominantly expressed in the pancreas, thyroid and kidney. Glis3 mRNA can be initially detected in mouse pancreas at embryonic day 11.5 and is largely restricted to β cells, pancreatic polypeptide-expressing cells, as well as ductal cells at later stage of pancreas development. Mutations in GLIS3 cause a neonatal diabetes syndrome, characterized by neonatal diabetes, congenital hypothyroidism and polycystic kidney.

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“…The second study reported that the same SNP exerts its effect also by generating either an intronic (CA) 16 STR, which was associated with an increased risk for prediabetes, or a (CA) 15 to (CA) 19 STR, which were all related to a decreased prediabetes risk 12 . Recently, a rather small case-control study confirmed the association of rs10886471 with prediabetes and type 2 diabetes, as well as with so-called differentiated symptoms of diabetes 32 . However, the association of the SNP rs10886471 with type 2 diabetes in the first study was found to be specific for East Asians, and the second and third studies were performed in only a Chinese Hainan Island population.…”

Section: Discussionmentioning

confidence: 91%

Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans

Lutz

Falcenberg

Machicao

et al. 2018

Sci Rep

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Genetically modified mice models suggest an important role for G-protein-coupled receptor kinase 5 (GRK5) in the pathophysiology of obesity and related disorders. We investigated whether single nucleotide polymorphisms (SNPs) in the gene encoding GRK5 affect cardiometabolic traits in humans. We genotyped 3 common SNPs in intron 1 (rs1980030, rs10466210, rs9325562) and one SNP in intron 3 (rs10886471) of GRK5 in 2332 subjects at risk for type 2 diabetes. Total- and visceral fat mass were measured by magnetic resonance (MR) tomography and liver fat content by 1H-MR spectroscopy. Insulin secretion and sensitivity were estimated during an OGTT and measured during the euglycemic, hyperinsulinemic clamp (n = 498). Carriers of the minor allele of rs10466210 and rs1980030 had higher total- and LDL-cholesterol levels (p = 0.0018 and p = 0.0031, respectively, for rs10466210; p = 0.0035 and p = 0.0081, respectively, for rs1980030), independently of gender, age, BMI and lipid-lowering drugs. The effects of rs10466210 withstood Bonferroni correction. Similar associations were observed with apolipoprotein B levels (p = 0.0034 and p = 0.0122, respectively). Carriers of the minor allele of rs10466210 additionally displayed a trend for higher intima-media thickness of the carotid artery (p = 0.075). GRK5 may represent a novel target for strategies aiming at lowering LDL-cholesterol levels and at modifying cardiovascular risk.

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Association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study

Abstract: Both T2DM and IGR exhibited its corresponding characteristic symptoms. The variants of GRK5 were involved with both qi-yin deficiency syndrome and dampness-heat encumbering Pi syndrome.

Cited by 12 publications

References 26 publications

Association Between Single Nucleotide Polymorphisms in CDKAL1 and HHEX and Type 2 Diabetes in Chinese Population

Association Between Single Nucleotide Polymorphisms in CDKAL1 and HHEX and Type 2 Diabetes in Chinese Population

Emerging roles of GLIS3 in neonatal diabetes, type 1 and type 2 diabetes

Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans

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