Association between glutathione peroxidase‐3 activity and carotid atherosclerosis in patients with type 2 diabetes mellitus

Ling, Ping; Shan, Wanying; Zhai, Guojie; Qiu, Chunfang; Liu, Yuan; Xu, Yuan; Yang, Xiaojie

doi:10.1002/brb3.1773

Cited by 19 publications

(15 citation statements)

References 39 publications

(49 reference statements)

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“…15) In fact, the pathophysiological process of CAD is mainly atherosclerosis, in which dyslipidemia and chronic inflammation of the arteries as well as various inflammatory factors play a central role. 16) Studies have demonstrated that the hsCRP level and dyslipidemia have a synergistic effect on the pathogenesis of CAD, and the association between dyslipidemia and CAD seems to be strengthened by the increased hsCRP level. The mediation analysis revealed that hs-CRP played a partial mediating role in the relationship between dyslipidemia and CAD (8.27%).…”

Section: Discussionmentioning

confidence: 99%

High-Sensitivity C-Reactive Protein to HDL-C Ratio

2021

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Section: Discussionmentioning

confidence: 99%

High-Sensitivity C-Reactive Protein to HDL-C Ratio

2021

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“…In fact, the pathophysiological process of CAD is mainly atherosclerosis, in which dyslipidemia and chronic in ammation of the arteries as well as various in ammatory factors play a central role 11 . Studies have shown that hs-CRP levels and dyslipidemia have a synergistic effect in the pathogenesis of CAD, and the association between dyslipidemia and CAD seems to be strengthened by the increased hs-CRP levels.…”

Section: Discussionmentioning

confidence: 99%

Hypersensitive C-reactive Protein to HDL-C Ratio Predicts the Severity of Coronary Artery Disease

Luo¹,

Kou²,

Yin³

2020

Preprint

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Background: Lipid and inflammatory molecules play a key role in the development of coronary atherosclerosis. Hypersensitive C-reactive proteins are used as markers of inflammation duration, and HDL-C is used as an anti-atherosclerosis component. However, few studies have combined the two indicators to explore coronary stenosis. We suggested that Hypersensitive C-reactive proteins as a marker of inflammation persistence and HDL-C as an anti-atherosclerosis component should be integrated into a single biomarker , so as to explore the correlation of Hypersensitive C-reactive protein HDL-C ratio with the severity of coronary stenosis and to predict the severity of coronary stenosis in CAD patients.Methods: We examined 360 eligible patients who underwent coronary angiography. Based on the results of coronary angiography, patients with any major coronary arteries (the left anterior descending artery, the left circumflex artery, the left main coronary artery, the right coronary artery) whose lumen diameter reduced by more than 50% were defined as CAD + group (n = 139) .Patients with luminal stenosis but no more than 50% were defined as CAD- group (n = 41), and patients without luminal stenosis (n = 180) were regarded as control group. The relationship between various serum markers and the severity of coronary stenosis was examined by Spearman correlation analysis. Logistic regression analysis was performed to identify the influencing factors of the severity of coronary artery disease.Results: The modified Gensini score was positively correlated with Hypersensitive C-reactive protein HDL-C ratio . Multiple regression analysis showed that Hypersensitive C-reactive protein HDL-C ratio were significantly associated with CAD. Hypersensitive C-reactive protein HDL-C ratio is an independent predictor of CAD. The ROC analysis provided a cut-off value of 1.17 for Hypersensitive C-reactive protein HDL-C ratio to predict CAD with 83.9% specificity and 0.242 Yoden index, and area under the ROC curve of 0.632 (95%CI 0.571-0.694, P <0.001).At the same time, the area under the ROC curve of Neutrophil HDL-C ratio was 0.620, indicating that Hypersensitive C-reactive protein HDL-C ratio as a predictor of CAD has better diagnostic performance than Neutrophil HDL-C ratio.Conclusion: Hypersensitive C-reactive protein HDL-C ratio is not only closely related to coronary artery stenosis, but also an independent predictor of severe coronary stenosis.

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“…Cytosolic antioxidant Thyrocyte protection from peroxidative damage [133,134] Overexpression of GPx1 associated with T2D-like phenotypes. Human GPX1 polymorphism related to risks of diabetes and obesity [135] GPx2 Extracellular antioxidant Thyrocyte protection from peroxidative damage [133,136] GPx3 involved in MetS, IR and T2D complications [137][138][139][140] GPx3 Membrane phospholipid antioxidant Antioxidant protecting the membrane, regulation of cellular death [141] GPx4 levels associated with clinical outcomes and metabolic abnormalities among patients with gestational diabetes mellitus. GPX4 involvement in high-glucose-induced ferroptosis (programmed cell death dependent on iron)…”

Section: Gpx1mentioning

confidence: 99%

Selenium and Selenoproteins at the Intersection of Type 2 Diabetes and Thyroid Pathophysiology

Gorini

Vassalle

2022

Antioxidants

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Type 2 diabetes (T2D) is considered one of the largest global public-health concerns, affecting approximately more than 400 million individuals worldwide. The pathogenesis of T2D is very complex and, among the modifiable risk factors, selenium (Se) has recently emerged as a determinant of T2D pathogenesis and progression. Selenium is considered an essential element with antioxidant properties, and is incorporated into the selenoproteins involved in the antioxidant response. Furthermore, deiodinases, the enzymes responsible for homeostasis and for controlling the activity of thyroid hormones (THs), contain Se. Given the crucial action of oxidative stress in the onset of insulin resistance (IR) and T2D, and the close connection between THs and glucose metabolism, Se may be involved in these fundamental relationships; it may cover a dual role, both as a protective factor and as a risk factor of T2D, depending on its basal plasma concentration and the individual’s diet intake. In this review we discuss the current evidence (from experimental, observational and randomized clinical studies) on how Se is associated with the occurrence of T2D and its influence on the relationship between thyroid pathophysiology, IR and T2D.

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Association between glutathione peroxidase‐3 activity and carotid atherosclerosis in patients with type 2 diabetes mellitus

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 19 publications

References 39 publications

High-Sensitivity C-Reactive Protein to HDL-C Ratio

High-Sensitivity C-Reactive Protein to HDL-C Ratio

Hypersensitive C-reactive Protein to HDL-C Ratio Predicts the Severity of Coronary Artery Disease

Selenium and Selenoproteins at the Intersection of Type 2 Diabetes and Thyroid Pathophysiology

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