Association between Glycated Hemoglobin with the Levels of Serum Proinflammatory Cytokines and Antioxidants in Patients with Type 2 Diabetes Mellitus in Universitas Sumatera Utara Hospital

Sari, Mayang; Tala, Zaimah Z.; Wahyuni, Dian

doi:10.3889/oamjms.2019.168

Cited by 10 publications

(6 citation statements)

References 33 publications

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“…It related to the secretion of prostaglandin by mesangial cells of kidney leading to changes in renal structure which are important in the development of DN [18]. In addition to this study ,Sari MI et alalsodetermined that serum IL-6 levels raised in patients with diabetic nephropathy [19]. Also a previous study has reported a significant difference in the IL-6 levels between a group of diabetic patients and a group of healthy people [20].…”

Section: Discussionsupporting

confidence: 50%

Evaluation of Some Inflammatory Cytokines and Glycated Hemoglobin in Uncontrolled Type 2 Diabetes Mellitus with Nephropathy

2020

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Background: Chronic hyperglycemia causes diabetic nephropathy(DN), which is a typical microvascular complication of type 2 diabetes mellitus. The pathogenesis of DN is not fully understanding. The inflammation may possess a significant role in the progression of DN in diabetic patients. Method:The study accomplished at teaching laboratories of medical city, Baghdad, Iraq.It was included 50uncontrolled diabetic type 2 patients with nephropathy, age range (40 -78) years and 42 controlled diabetics type 2 without nephropathy, age range (35 -52) years as a control group.The participants divided in to two groups according to HbA1c measurement which is described as follows: < 7.5% of HbA1c describes controlled diabetes, and > 9% of HbA1c describes uncontrolled diabetes. The calculation of the Glomerular filtration rate (GFR) was used to determine the renal function for each participant. A venous blood sample was obtained to estimate HbA1c,fasting serum glucose (FSG), urea, creatinine, interleukin-6(IL-6),interleukin-1 beta( IL-1β)and tumor necrosis factor -alpha(TNF-ɑ. ).Results : Significantly higher serum urea and creatinine levels in uncontrolled diabetic patients with nephropathy than controlled diabetic without nephropathy. The mean of HbA1c of DN group was higher as compare to diabetic control (DC) group, Results of IL-1β, IL-6 and TNF-ɑ exhibits a significant raised level for diabetics with nephropathy, (p< 0.05) for IL-1β, (p< 0.05) for IL-6 and (p< 0.01) for TNF-ɑ . Conclusion :Raised serum levels of TNF-ɑ, IL-1βand IL-6 in uncontrolled diabetic patients with nephropathy concurrently with raising the average HbA1c in them indicate that the inflammation may have a role in the advancement of DN in diabetic patients with poor glycemic control.

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Section: Discussionsupporting

confidence: 50%

Evaluation of Some Inflammatory Cytokines and Glycated Hemoglobin in Uncontrolled Type 2 Diabetes Mellitus with Nephropathy

2020

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“…The process continues to decrease antioxidants levels. Previous study showed that there was a decrease of glutathione peroxidase and glutathione in DM patients compared to healthy subjects [30]. The other study showed that decrease of SOD level occurred in tuberculosis patients with DM compared to healthy subjects [31].…”

Section: Discussionmentioning

confidence: 93%

The Gene Polymorphisms (-308G/A) and the Tumor Necrosis Factor-alpha Levels in Type 2 Diabetic Patients with and Without Tuberculosis Infection

Daulay

Sari

Wahyuni

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: The gene polymorphism (-308G/A) and tumor necrosis factor-alpha (TNF-α) levels influence development of disease in type 2 diabetic patients and tuberculosis patients. AIM: In this study, we analyze the association between the TNF-α polymorphisms (-308G/A) and the levels of TNF-α in type 2 diabetic patients with and without tuberculosis infection. METHODS: This study was an analytic observational with cross sectional approach consisting 40 type 2 diabetic patients with tuberculosis infection, 40 type 2 diabetic patients without tuberculosis infection and 40 healthy control (HC) subjects. The TNF-α gene polymorphism (-308G/A) was analyzed with polymerase chain reaction-restriction fragment lengths polymorphisms (PCR-RFLP) method. The TNF-α levels were measured using an enzyme-linked immunosorbent assay. The association between gene polymorphism (-308G/A) in study groups was analyzed by Fisher's exact test, tumor necrosis factor-alpha (TNF-α) levels in study groups was carried out using the Kruskal-Wallis test. Hardy-Weinberg Equilibrium also determined genotype deviation and allele frequencies. RESULTS: The GG and GA+AA genotypes frequency in both of patient groups and HC subjects were not differ significantly (95% and 5% vs 95% and 5% vs 92.5% and 7.5%; p > 0.05). The TNF-α levels (pg/ml) of type 2 diabetic without tuberculosis infection were higher than those of type 2 diabetic with tuberculosis infection and HC subjects (7.42 ± 0.78 vs 2.23 ± 0.51 vs 2.57 ± 0.63; p < 0.01). The TNF-α levels in the GA+AA genotypes were higher than the GG wild-type genotype (p > 0.05). There was no significant deviation of genotype frequency and allele from Hardy-Weinberg Equilibrium. CONCLUSION: The gene polymorphism (-308G/A) had no association with type 2 diabetic patients with and without tuberculosis infection and the gene polymorphism (-308G/A) was not influence the TNF-α levels but there was a significant differentiation of TNF-α levels between the groups.

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“…Interleukin-6 (IL-6) is a pro-inflammatory cytokine that has been implicated in various conditions such as cardiovascular disease, diabetes mellitus, etc. 14,15,16 Circulating levels of IL-6 may be influenced by common genetic variants of the IL-6 gene promoter. Several IL-6 gene SNPs in the IL-6 promoter region have been identified, such as SNP rs1800797 (-597 G/A or -598 G/A).…”

Section: Resultsmentioning

confidence: 99%

The Interleukin-6 (rs1800797) Variant in Healthy Individuals at Medan City, North Sumatera Province

Sari¹,

Syarifah²,

Daulay³

et al. 2021

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The Interleukin-6/IL6 (rs1800797) variant play a role in several diseases pathogenesis. The frequency genotype of IL6 (rs1800797) varied based on different race, ethnicity, and underlying character in population. This study aimed to assess the frequency of genotype and allele of IL6 (rs1800797) in healthy individuals at Medan city, North Sumatera Province Province and this study can be used as a reference in determining of several diseases for further studies. Genotyping of IL6 (rs1800797) in the promoter region using polymerase chain reaction and restriction fragment length polymorphism method, analysis using FokI restriction enzyme. This study showed that the genotype frequency of GG, GA, and AA were 95.8 %, 4.2 %, and 0 %, respectively. The allele frequency of G and A were 97.9 % and 2.1 %, respectively. The results indicated that the homozygous wild-type (GG) of IL6 (rs1800797) was higher than the heterozygous mutant (GA) and there was absent of homozygous mutant (AA) in this population. The frequency of G allele also higher than A mutant allele.

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Association between Glycated Hemoglobin with the Levels of Serum Proinflammatory Cytokines and Antioxidants in Patients with Type 2 Diabetes Mellitus in Universitas Sumatera Utara Hospital

Cited by 10 publications

References 33 publications

Evaluation of Some Inflammatory Cytokines and Glycated Hemoglobin in Uncontrolled Type 2 Diabetes Mellitus with Nephropathy

Evaluation of Some Inflammatory Cytokines and Glycated Hemoglobin in Uncontrolled Type 2 Diabetes Mellitus with Nephropathy

The Gene Polymorphisms (-308G/A) and the Tumor Necrosis Factor-alpha Levels in Type 2 Diabetic Patients with and Without Tuberculosis Infection

The Interleukin-6 (rs1800797) Variant in Healthy Individuals at Medan City, North Sumatera Province

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