Association Between HDL-C and Bone Mineral Density: An Cross-Sectional Analysis

Abstract

Background: Dyslipidemia has been found to contribute to increased risk of osteoporosis and its association with bone mineral density (BMD) remains controversial. We determined whether blood lipid levels are linked with change of BMD. Methods: In a large sample from the MIDUS II study, we sought to evaluate the relationship between blood lipid levels and BMD. Multivariate linear regression models and smooth curve analysis were constructed by controlling a great range of confounding factors. Results:The median age of them was 52.5 years, and the number of males was 176 (40%). Univariate analysis showed that blood high-density lipoprotein-cholesterol (HDL-C) level was negatively related to lunar total femur (r = −0.266, P < 0.001), lunar radius ultradistal (UD) (r = −0.297, P < 0.001), lunar radius 1/3 (r = −0.307, P = 0.001) and femoral neck (r = −0.172, P = 0.001). In multivariate linear analysis, except for blood triglyceride, total cholesterol and low-density lipoprotein cholesterol (LDL-C), we found that blood HDL-C level was still negatively related to lunar total femur [B = −0.002, B 95% CI (−0.002, −0.001), P < 0.001], lunar radius UD [B = −0.001, 95% CI (−0.001, 0), P = 0.002], lunar radius 1/3 [B = −0.001, 95% CI (−0.001, 0), P = 0.003] and femoral neck [B = −0.001, 95% CI (−0.002, 0), P = 0.039] after adjustments of demographic characteristics, lifestyle, disease history were made. Furthermore, we found that age, sex, and body mass index (BMI) had modifying effects on this negative association. Conclusion:This study confirmed the negative association between HDL-C and BMD in the observational analysis from (MIDUS) study and provides high-quality evidence that age, sex and BMI had modifying effects on this negative association.

The role of metabolites under the influence of genes and lifestyles in bone density changes

“…We found that increased tea consumption was positively associated with increased T-score which was mediated through the levels of subfractions of HDL (H.CH, H2CH, H2CE, H3FC, H3CH, and H3CE) and VLDL (V1CH, V1PL, V1FC, V1CE, V1LP, and V1TG) in our results. Meanwhile, HDL has been negatively correlated with BMD, and VLDL has been positively correlated with BMD according to previous research, which is an effective support for our results (10,72). A study has pointed out that long-term tea consumption is related to the reduction of HDL and may destroy the reverse cholesterol transport process mediated by HDL (73).…”

The correlation between high-density lipoprotein cholesterol and bone mineral density in adolescents: a cross-sectional study

“…These three cholesterols indicated an inversive association with BMD in Chinese postmenopausal participants 12 . Peng Niu et al confirmed the inverse correlation of HDL-C level and BMD through their analysis of the MIDUS II study 21 . However, Irene Zolfaroli et al revealed that HDL-C level, but not TC and LDL-C, was positively relevant to the femoral neck and lumbar BMD 22 .…”

High cholesterol and low triglycerides are associated with total lumbar bone mineral density among adults aged 50 years and over: The NHANES 2017–2020

“…In most studies, a higher level of cholesterol was found to be associated with an increased risk of osteoporosis or a lower BMD ( 5 – 8 ). A non-association between cholesterol and BMD was also reported ( 9 – 11 ). Our findings that higher total cholesterol levels are associated with lower spine BMD do support the most previous research studies.…”