The correlation between high-density lipoprotein cholesterol and bone mineral density in adolescents: a cross-sectional study

Wang, Gao‐Xiang; Li, Jun-Tong; Liu, Deliang; Chu, Shu-Fang; Li, Hui-Lin; Zhao, Hengxia; Fang, Ze-Bin; Xie, Wei

doi:10.1038/s41598-023-32885-x

Cited by 7 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the NHANES 2011–2018 data, a study conducted by Xiao et al found a negative relationship between LDL-C levels and lumbar BMD in the young- and middle-aged population [ 5 ]. Additionally, Wang's study, after accounting for all relevant covariates, revealed an interesting inverted U-shaped curve representing the correlation between HDL-C levels and total BMD among adolescents aged 16–19 [ 33 ]. Conversely, in the general population aged 20–59, HDL-C levels demonstrated a positive association with lumbar BMD [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Zhan,

Liu,

Piao

et al. 2023

J Orthop Surg Res

View full text Add to dashboard Cite

Objective Disorders in glucose and lipid metabolism have been shown to exert an influence on bone metabolism. The TyG index, which combines measures of glucose and triglycerides, provides insights into the overall metabolic status. However, the investigation of concurrent disturbances in glucose and lipid metabolism and their specific implications for bone metabolism remains limited in the existing research literature. This study aimed to explore the correlation between the TyG index and bone mineral density (BMD) in US adults. Methods In the National Health and Nutrition Examination Survey (NHANES), subjects were classified based on the TyG index into four groups (< 7.97, 7.97–8.39, 8.39–8.85, > 8.86). Linear regression analysis was conducted to determine the β value and 95% confidence interval (CI). Four multivariable models were constructed. Restricted cubic spline analyses and piecewise linear regression were employed to identify the association between the BMD and TyG index. An analysis of subgroups was also conducted in this study. Results Significant variations in related characteristics were found among the US adult population, who were distributed into four groups based on the quartiles of the TyG index. A negative correlation between the TyG index and lumbar spine BMD was observed. In the multi-adjusted models, compared to Q1 of the TyG index, the β for Q4 of the TyG index for lumbar spine BMD was [β = − 0.008, 95% CI (− 0.017, 0)] in US adults. The association between the TyG index and lumbar spine BMD was found to be nonlinear (all nonlinear p < 0.001), with a threshold value based on restricted cubic spline analyses. Above the threshold point, the β for lumbar spine BMD was − 0.042 (95% CI, − 0.059, − 0.024). Below the threshold points, no significant difference was observed (p > 0.05). No significant interactions were observed among subgroups based on age, gender, presence of diabetes, BMI, and use of antidiabetic and antihyperlipidemic agents. Similar patterns of association were observed in total and subtotal bone density. Conclusions This study identified a nonlinear association between the TyG index and BMD in the US population. Furthermore, an increased level of the TyG index may indicate a higher risk of osteoporosis among US adults. These findings highlight the importance of considering glucose and lipid metabolism disturbances in understanding bone health and the potential for developing preventive strategies for osteoporosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Zhan,

Liu,

Piao

et al. 2023

J Orthop Surg Res

View full text Add to dashboard Cite

show abstract

“…However, multiple researches have shown conflicting outcomes. In a MIDUS study of 440 participants the authors found that elevated blood levels of HDC-L were associated with a lower bone density [ 27 ], Another cross-sectional investigation of teenagers purportedly found a negative relationship between male adolescents' total BMD and HDL-C levels [ 28 ]. Furthermore, the authors of a cross-sectional study with 13,592 participants reported no associations between BMD and total cholesterol, LDL, or HDL levels in fully adjusted models [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

The association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of osteoporosis among U.S. adults: analysis of NHANES data

Wang,

Li,

et al. 2024

Lipids Health Dis

View full text Add to dashboard Cite

Background Osteoporosis and atherosclerosis frequently afflict older adults, and recent insights suggest a deeper connection between these conditions that surpasses mere aging effects. The ratio of non-high-density to high-density lipoprotein cholesterol (NHHR) has emerged as a novel lipid marker for evaluating the risk of cardiovascular diseases. Nonetheless, investigations into the correlation of the NHHR with the risk of developing osteoporosis remain unexplored. Methods We collected NHHR and bone mineral density (BMD) data from 11,024 National Health and Nutrition Examination Survey (NHANES) participants between 2011 and 2018. Multivariate linear regression was employed to examine the correlation between BMD and NHHR. Smooth curves were employed to deal with the nonlinearity. To further account for the nonlinear link, we used a two-part linear regression model. The threshold effects were estimated using two components of a linear regression model. Subgroup and sensitivity analyses were carried out to ascertain the stability of the findings. Results We discovered a negative relationship between the NHHR and lumbar spine BMD in all three models. An L-shaped curvilinear association existed between the NHHR and lumbar spine BMD, with a key inflection point of 6.91. The fully adjusted model showed that the BMD of the lumbar spine fell by 0.03 g/cm2 in those who were in the fourth quartile as opposed to the lowest quartile. The sensitivity analysis using unweighted logistic analysis verified the stability of the results. In addition, BMD in the nondiabetic group was more significantly affected by the negative effect of the NHHR in the subgroup analysis. Conclusions According to this research, there appears to be a negative correlation between BMD and NHHR in US Adults. To clarify the precise physiological mechanisms by which the NHHR contributes to the onset of osteoporosis, more research is necessary.

show abstract

“…Dyslipidemia is a medical condition characterized by high levels of triglycerides and their associated lipoproteins in the bloodstream [ 8 , 9 ]. Nevertheless, the majority of recent studies have concentrated on examining the association between a solitary variable and BMD [ 10 , 11 ], and even the opposite results [ 12 – 14 ]. As a result, multiple clinical studies attempt to identify an osteoporosis risk marker that accurately predicts dyslipidemia [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Non-linear association of atherogenic index of plasma with bone mineral density a cross-sectional study

Xu,

Ma,

Yang

et al. 2024

Lipids Health Dis

View full text Add to dashboard Cite

Introduction Although there has been abundant evidence of the association between dyslipidemia as a single factor and osteoporosis, the non-linear relationship between osteoporosis and the Atherogenic Index of Plasma (AIP) has not yet been thoroughly investigated. This study aimed to investigate the complex relationship between AIP and bone mineral density (BMD) to elucidate their interrelationship. Methods An analysis of 2007–2018 National Health and Nutrition Survey (NHANES) data was conducted for this study. The study enrolled 5,019 participants. Logarithmically multiplying triglycerides and high-density lipoprotein cholesterol yields the AIP (base 10). The measured variables consisted of BMD in the total femur (TF), femoral neck (FN), and lumbar spine (LS). The association between AIP and BMD was examined using a range of statistical models, such as weighted multivariable logistic regression, generalized additive model, etc. Results It was found that AIP was positively associated with BMD after adjusting for age, gender, race, socioeconomic status, degree of education, income, Consuming alcoholic beverages, osteoporosis status (Yes or No), ALT, AST, serum creatinine, and total calcium levels. Further studies supported the association link between elevated BMD and AIP. Furthermore, compared to men, females had a higher positive connection between AIP and BMD. In general, there was a curve in the reverse L-shape seen, with a point of change around 0.877, indicating a relationship between AIP and TF BMD. Moreover, a curve exhibiting an L-formed pattern, with a point of inflection at around 0.702, was seen between AIP and FN BMD. In addition, a J-shaped curve was seen, with a point of inflection at 0.092, which demonstrates the association between AIP and LS BMD. Conclusion The AIP and TF BMD curves resemble inverted L shapes, as do the AIP and FN BMD curves. The relationship between AIP and LS BMD was further demonstrated by a J-shaped curve. The results indicate a possible association between AIP and bone mineral density, which should be explored in more detail.

show abstract

The correlation between high-density lipoprotein cholesterol and bone mineral density in adolescents: a cross-sectional study

Cited by 7 publications

References 28 publications

Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

The association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of osteoporosis among U.S. adults: analysis of NHANES data

Non-linear association of atherogenic index of plasma with bone mineral density a cross-sectional study

Contact Info

Product

Resources

About