Association between Helicobacter pylori Infection and Iron Deficiency Anemia in School-aged Iranian Children

Zahmatkeshan, Mozhgan; Karimi, Mehran; Geramizadeh, Bita; Eslaminasab, Somayeh; Esmailnejad, Atefeh; Safarpour, Ali Reza

doi:10.1007/s13312-019-1536-0

Cited by 14 publications

(14 citation statements)

References 11 publications

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“…The current European Society for Paediatric Gastroenterology, Hepatology and Nutrition and the North American Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN/ NASPGHAN) guidelines conclude that there is no association with iron deficiency anemia (IDA), and a weak association between refractory IDA and H pylori infection 8 . A recent study of Iranian children found no association with H pylori infection and IDA, supporting previous findings 21 . Based on weak evidence, current ESPGHAN/NASPGHAN guidelines suggest that chronic idiopathic thrombocytopenic purpura (ITP) is an indication to test for H pylori infection and treat if positive.…”

Section: Clinical Manifestations Of H Pylorimentioning

confidence: 56%

Review: Helicobacter pylori infection in children

2020

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Helicobacter pylori infection in children and adolescents differs in comparison to adults with respect to epidemiology, host responses, and disease manifestations. Furthermore, treatment options are limited in this population and antibiotic resistance rates continue to increase. Therefore, ongoing research is vital to understand disease pathogenesis and provide optimal management of children with infection. This review summarizes relevant publications from April 2019 to March 2020. Similar to adults, recent studies show a decreasing prevalence of infection in the pediatric population. Studies of pathogenesis investigated serum immune responses and the potential inverse association of infection and allergy. Several studies investigated the effect of H pylori and related inflammation on the gut microbiome. The recommendation of endoscopy‐based testing to identify the cause of symptoms and not just H pylori, reserving noninvasive UBT or stool antigen tests for post‐eradication follow‐up, was supported by the current literature.

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Section: Clinical Manifestations Of H Pylorimentioning

confidence: 56%

Review: Helicobacter pylori infection in children

2020

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“…1). There were eight cross-sectional studies, 15,17,18,[27][28][29][30][31] six RCTs, 13,[32][33][34][35][36] five case-control studies, 12,16,20,21,37 two surveys, 11,38 and one cohort study. 14 Only six studies reported participants' average age, hemoglobin, and serum ferritin levels 14,20,28,29,31,36 (►Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…According to the World Bank classification of economic level, six studies 16,27,[31][32][33]35 with a total sample size of 2,086 were conducted in countries with lower middle incomes. In addition, eight studies 11,14,15,17,28,30,36,38 with a total sample size of 3,990 were from high incomes countries and eight 12,13,18,20,21,29,34,37 with a total sample size of 1,813 were from countries with upper middle incomes. Studies included in the meta-analysis were grouped according to the methods used to diagnose H. pylori.…”

Section: Resultsmentioning

confidence: 99%

The Association between Helicobacter Pylori Infection and Iron Deficiency Anemia in Children: A Systematic Review and Meta-Analysis

Hamdan

Nimieri

et al. 2022

J Pediatr Infect Dis

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Objectives This study, comprising a systematic review and meta-analysis, was conducted to assess the association between Helicobacter pylori infection and the risk of iron deficiency anemia (IDA) in children. Methods We followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant published studies were searched in the databases. Retrieved studies were assessed for quality using the Modified Newcastle-Ottawa Scale for quality assessment. The “meta” package of statistical software “R 4.0.3 was used for statistical analysis. Results Overall, 22 eligible studies (eight cross-sectional, six randomized control trials, five case-control, two surveys, and one cohort), including nine (40.9%) from Asia, four (18.1%) from America, four (18.1%) from Africa, four (18.1%) from Europe, and one (4.5%) from Australia with a total of 3,434 cases and 4,455 controls were included in this systematic review and meta-analysis. We found that H. pylori infection was associated with a high risk of IDA (odds ratio 1.70, 95% confidence interval 1.21 − 2.38) in a random-effects model. Meta-regression analysis showed that none of the investigated factors that may affect the prevalence of IDA reached statistical significance. There was statistically significant difference between results when studies were categorized according to the methods used to diagnose H. pylori and level of incomes based on World Bank classification. The GRADEpro Guideline Development Tool evidence for the risk of IDA was of a “moderate certainty.” Conclusions This meta-analysis with a “moderate certainty” of evidence showed an association between H. pylori infection and a high risk of developing IDA in children.

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“…Our study in line with case-control study by Haghi-Ashtiani MT et al in Iran on children with gastritis, they found no significant difference in hemoglobin values between children with H. pylori infection and non-H. pylori infection 23 and a cross-sectional study by Zahmatkeshan M et al in Iran on children under 18 years of age also found no significant relationship between H. pylori infection and anemia. 24 In our study, a rapid urease test or Campylobacter-like Organism test (CLO test) was used to determine whether a subject infected with Helicobacter pylori or not because this in some study has higher sensitivity and specificity test. 25 Our study showed no difference in transferrin values between groups with H. pylori infection and non-H. pylori infection.…”

Section: Discussionmentioning

confidence: 99%

Differences of Hemoglobin and Transferrin Level between Helicobacter Pylori Gastritis and Non-Helicobacter Pylori Gastritis in Children

Hensen¹,

Supriatmo²,

Ramayani³

et al. 2020

IJRP

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Background: Gastritis can reduces the hemoglobin level. Based on previous study, gastritis resulted from Helicobacter pylori infection often correlated to anemia as the capability of Helicobacter pylori to obtain iron from hemoglobin and transferrin. Objective: To analysis the differences of hemoglobin and transferrin level between Helicobacter pylori gastritis and non-Helicobacter pylori gastritis in children. Method: A cross sectional study was conducted on outpatient and inpatient in Haji Adam Malik General Hospital, Medan and network hospitals on March-April 2020, subject ages from 2 to 18 years, diagnosed with Helicobacter pylori gastritis and non-Helicobacter pylori gastritis based on CLO test. Blood sample was taken from subjects to evaluate hemoglobin and transferrin level. Result: 54 subjects with gastrointestinal complaints were recruited. Subjects were divided into 2 groups based on CLO test, 32 subjects with Helicobacter pylori and 22 subjects without Helicobacter pylori. From blood sample analysis, mean hemoglobin and transferrin value from Helicobacter pylori group was 10.9 gr/dL and 253.5 mg/dL. Meanwhile, mean hemoglobin and transferrin value from non-Helicobacter pylori group was 10.8 gr/dL and 261.9 mg/dL. (p>0.05). Conclusion: No difference in hemoglobin and transferrin level between Helicobacter pylori gastritis and non-Helicobacter pylori gastritis in children.

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Association between Helicobacter pylori Infection and Iron Deficiency Anemia in School-aged Iranian Children

Cited by 14 publications

References 11 publications

Review: Helicobacter pylori infection in children

Review: Helicobacter pylori infection in children

The Association between Helicobacter Pylori Infection and Iron Deficiency Anemia in Children: A Systematic Review and Meta-Analysis

Differences of Hemoglobin and Transferrin Level between Helicobacter Pylori Gastritis and Non-Helicobacter Pylori Gastritis in Children

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