Association between Helicobacter pylori infection and colorectal neoplasm risk: A meta-analysis Based on East Asian population

Abstract

In general, no statistical association between HP infection and colorectal neoplasm risk was found in this meta-analysis. But, HP infection may increase the risk of developing colorectal adenomas.

Prediagnostic Helicobacter pylori Antibodies and Colorectal Cancer Risk in an Elderly, Caucasian Population

“…These differences in population characteristics may explain, at least in part, the discrepancies between our results and those of Epplein et al . Previous studies support the idea of differences by study population in the association between H. pylori and colorectal cancer as well as precursors such as polyps and adenomas .…”

The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking

“…Abbreviation: HP, Helicobacter pylori; Hx, history disagree. 12,13,26,27 The reason for this discrepancy is currently uncertain, but our results suggest that age is an important factor that determines the association between H. pylori and ACN. In line with our results, studies by Limburg et al, 28 Chen et al, 12 and Blase et al, 13 suggesting that H. pylori did not increase the level of gastrin in the elderly.…”

Helicobacter pylori, gastric cancer and other gastrointestinal malignancies

“…21 In this study, Lee et al Previous studies, however, showed that the observed relationship between H. pylori and CRC could be population related. 23,24 In a nested case-control study on an elderly, mainly Caucasian population (392 cases, 774 controls, age: 56-87 years, median age when blood was drawn: 71 years), the association between H. pylori seropositivity, defined as reactivity to at least 4 of 15 analyzed proteins, and CRC was evaluated. Overall H. pylori seropositivity was not related to a higher CRC risk.…”