Association between Helicobacter pylori infection and nonalcoholic fatty liver

Liu, Rongqiang; Liu, Qiuli; He, Ying; Shi, Wen‐Qing; Xu, Qianhui; Yuan, Qing; Qi, Lin; Li, Biao; Ye, Lei; Min, You‐Lan; Zhu, Pei‐Wen; Shao, Yi

doi:10.1097/md.0000000000017781

Cited by 34 publications

(30 citation statements)

References 41 publications

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“…Most of the prior studies have been conducted among Asian populations and further evidence from outside Asia has replicated these findings 8,10 . Meta‐analyses have reported positive associations between H pylori and NAFLD with ORs ranging from 1.14 to 1.53, but noted high heterogeneity among the studies 12‐16 . The heterogeneity may be due to differences in the NAFLD definition and the covariates used for the adjustment in the analyses 12‐16 .…”

Section: Discussionmentioning

confidence: 94%

“…Meta‐analyses have reported positive associations between H pylori and NAFLD with ORs ranging from 1.14 to 1.53, but noted high heterogeneity among the studies 12‐16 . The heterogeneity may be due to differences in the NAFLD definition and the covariates used for the adjustment in the analyses 12‐16 . In addition, a meta‐analysis from China found a positive association between H pylori infection and risk of obesity among adults, 48 while a systematic review reported that H pylori was associated with insulin resistance 52 …”

Section: Discussionmentioning

confidence: 99%

“…Recent evidence has suggested that H pylori is associated with the development of NAFLD 7‐11 . Several meta‐analyses, predominantly from studies of Asian populations, have reported H pylori infection‐NAFLD associations with pooled odds ratios ranging between 1.14 and 1.53 12‐16 …”

Section: Introductionmentioning

confidence: 99%

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Associations between Helicobacter pylori with nonalcoholic fatty liver disease and other metabolic conditions in Guatemala

et al. 2020

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Background Previous studies have suggested an association between Helicobacter pylori (H pylori) and nonalcoholic fatty liver disease (NAFLD). The aim of the current study was to examine the association in Guatemala, a region with elevated prevalences of both H pylori and NAFLD. Associations between H pylori and other metabolic conditions were also examined, as were associations between H hepaticus and H bilis and the metabolic conditions. Materials & Methods The analysis included 424 participants from a cross‐sectional study in Guatemala. H pylori seropositivity was defined as positivity for ≥ 4 antigens. Seropositivities for H bilis and H hepaticus were defined as positivity for ≥ 2 antigens. NAFLD was estimated using the Fatty Liver Index and the Hepatic Steatosis Index. Other conditions examined were obesity, central obesity, hypercholesterolemia, low HDL, diabetes and metabolic syndrome (MetSyn). Prevalence odds ratios (POR) and 95% confidence intervals (CIs) were estimated. Results No overall associations between H pylori,H hepaticus, or H bilis and NAFLD or related metabolic conditions were found. Seropositivity for H pylori antigens CagA and VacA and H hepaticus antigen HH0713 was each significantly associated with NAFLD, however. In addition, associations were observed between the H pylori antigens HyuA, HP1564, and UreA and specified metabolic conditions. Conclusions While no overall associations between H pylori or Helicobacter species with NAFLD or related conditions were observed, some selected Helicobacter spp. antigens were associated with NAFLD. Further research is warranted to examine whether H. species are associated with any metabolic condition.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Associations between Helicobacter pylori with nonalcoholic fatty liver disease and other metabolic conditions in Guatemala

et al. 2020

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“…Subsequently, other studies reported a positive association between Hp-I and NAFLD, including those of Yu et al [19], Sumida et al [38], Okushin et al [18], Kim et al [10,27], Zhang et al [21], Chen et al [26], Dogan et al [25], Abdel-Razik et al [24], and Kang et al [11]. Noteworthy, there have been five systematic reviews performed with meta-analysis, all of which revealed a positive association between the pathologies of interest [39][40][41][42][43]. Nonetheless, there are studies showing no association between Hp-I and NAFLD [14,15,19,20,22].…”

Section: Discussionmentioning

confidence: 99%

Active Helicobacter pylori Infection is Independently Associated with Nonalcoholic Steatohepatitis in Morbidly Obese Patients

Doulberis

Srivastava²,

Polyzos

et al. 2020

JCM

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Nonalcoholic fatty liver disease (NAFLD) emerges as an important global burden and Helicobacter pylori infection (Hp-I) has been suggested as a risk factor of NAFLD, although controversy exists. This retrospective study aimed to investigate a potential impact of active Hp-I on NAFLD severity in morbidly obese patients, subjected to bariatric surgery and gastric biopsy for documentation of Hp-I. Of 64 eligible participants, 15 (23.4%) were diagnosed with active Hp-I, showing higher rates of nonalcoholic steatohepatitis (NASH) than those without Hp-I (86.7% vs. 26.5%, respectively; p < 0.001). Concerning histological lesions, steatosis grade (p = 0.027), ballooning (p < 0.001), lobular inflammation (p = 0.003), and fibrosis stage (p < 0.001) were also more severe in Hp-I positive patients. Likewise, liver function tests, insulin resistance, dyslipidemia, and arterial hypertension were significantly higher in Hp-I positive patients. Hp-I was independently positively associated with NASH (beta = 3.27; p = 0.002), severe NASH (beta = 2.37; p = 0.018), and the presence of fibrosis (beta = 3.86; p = 0.001) in a binary regression model, after adjustment for potential confounders. In conclusion, active Hp-Ι was independently associated with NASH and fibrosis, findings offering potential clinical implication.

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“…25 Considering the recent marked reduction in viral hepatitis and the increase in non-alcoholic fatty liver disease (NAFLD) prevalence, 26 the association between H pylori infection and NAFLD has also been evaluated. Four recently published meta-analyses [27][28][29][30] showed a significant association between H pylori infection and NAFLD. This finding was confirmed in a cross-sectional study including 646 patients.…”

Section: Hepatob Iliary D Is E a S E Smentioning

confidence: 99%

Review: Extragastric diseases andHelicobacter pylori

et al. 2020

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The involvement of Helicobacter pylori infection in many extra‐gastroduodenal manifestations remains a fascinating field of investigation. However, for several of these supposed associations, the potential pathogenic mechanism remains unclear. The present review highlights the main associations of H pylori with extra‐gastroduodenal manifestations reported during the last year. We searched for the most relevant studies on this topic, published between April 2019 and March 2020, identified using the term “Helicobacter” in the MEDLINE/Pubmed database. Consistent data emerged from studies investigating metabolic syndrome and ischaemic cardiovascular diseases. Other reported fields of investigation were hepatology, especially focused on non‐alcoholic steatohepatitis, neurology, including Parkinson’s disease and Alzheimer’s disease, as well as dermatology. Inflammatory bowel disease (IBD), that comprises Crohn’s disease and ulcerative colitis, may originate from a dysregulation of the host’s immune response to commensal bacteria in individuals with genetic predisposition. The reduction of biodiversity and other specific imbalances in the faecal microbiome composition of IBD patients compared to that of healthy controls support this hypothesis. In this context, an inverse correlation between H pylori infection and IBD prevalence has been confirmed. Similar results were found in patients with kidney diseases and allergic manifestations. There are indications of the possible involvement of H pylori infection in metabolic syndrome and ischaemic cardiovascular diseases. However, due to a series of factors linked to study designs and the multifactorial pathogenesis of some diseases, further studies are needed.

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Association between Helicobacter pylori infection and nonalcoholic fatty liver

Cited by 34 publications

References 41 publications

Associations between Helicobacter pylori with nonalcoholic fatty liver disease and other metabolic conditions in Guatemala

Associations between Helicobacter pylori with nonalcoholic fatty liver disease and other metabolic conditions in Guatemala

Active Helicobacter pylori Infection is Independently Associated with Nonalcoholic Steatohepatitis in Morbidly Obese Patients

Review: Extragastric diseases andHelicobacter pylori

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