2003
DOI: 10.1016/s0090-8258(03)00320-2
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Association between high-risk human papillomavirus DNA load and precursor lesions of cervical cancer in Mexican women

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Cited by 61 publications
(54 citation statements)
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“…They concluded that a clear association between viral load of HPV DNA was determined by HC II assay and CIN grade. 12 Park et al 13 reported similar results. They reviewed a total of 259 women who had CIN confirmed by cervical colposcopy-directed biopsy or conization, and showed the odds ratio of the development of CIN 2-3 was 9.0-9.6 in patients with high viral load.…”
Section: -13mentioning
confidence: 67%
See 1 more Smart Citation
“…They concluded that a clear association between viral load of HPV DNA was determined by HC II assay and CIN grade. 12 Park et al 13 reported similar results. They reviewed a total of 259 women who had CIN confirmed by cervical colposcopy-directed biopsy or conization, and showed the odds ratio of the development of CIN 2-3 was 9.0-9.6 in patients with high viral load.…”
Section: -13mentioning
confidence: 67%
“…[8][9][10] The Food and Drug Administration (FDA) has approved the HC II using a liquid-based cervical smear preparation. Several studies using HC II have reported that HPV DNA load levels were significantly increased in high-grade cervical lesions (CIN 2 or 3) compared to low-grade lesion [11][12][13] although a few investigators have failed to confirm this relationship. 14,15 While the HPV load may be an important predictor of the severity of CIN, the relationship between HPV load and prognosis of patients with cervical carcinoma has not yet been clearly defined.…”
Section: Introductionmentioning
confidence: 99%
“…En los países de América Latina, en donde los programas de prevención de cáncer de cuello uterino no han alcanzado los resultados esperados (26) estos porcentajes son mayores: entre 20% y 75% (13,17,22,(27)(28)(29)(30). Si bien las comparaciones deben realizarse con precaución -debido a las diferencias en los sistemas de salud, las poblaciones incluidas en los estudios y las definiciones de abandono-el porcentaje de abandono estimado para la provincia de Jujuy es similar a los reportados en estudios realizados en México, Colombia y Brasil: 20%, 27% y 29% respectivamente (22,28,29).…”
Section: Discussionunclassified
“…Estos resultados son consistentes con otras investigaciones (22,28) y pueden ser considerados indicadores de falencias en el traspaso de información y responsabilidades entre los servicios de tamizaje y los de diagnóstico y tratamiento, relevadas en diversos estudios (20,27). La trayectoria de atención de una mujer que es derivada para realizar una biopsia sale del ámbito del profesional que realizó el tamizaje, quien muchas veces desconoce el resultado final del proceso (12).…”
Section: Discussionunclassified
“…Previous studies using either quantitative PCR [17][18][19][20][21] or hybrid capture II assays [22][23][24] also found viral load to be associated with CIN III, though the reported magnitude of risk varied widely, from 3-to 365-fold. High viral load may be a surrogate for viral persistence, but longitudinal studies would be required to address this.…”
Section: Discussionmentioning
confidence: 99%