Association Between High Serum Soluble Corin and Hypertension: A Cross-Sectional Study in a General Population of China

Peng, Hao; Zhang, Qiu; Cai, Xiaoqin; Liu, Yan; Ding, Jiansong; Tian, He; Chao, Xiangqin; Shen, Hengshan; Jiang, Li; Jin, Jooyeon; Zhang, Yonghong

doi:10.1093/ajh/hpv002

Cited by 49 publications

(47 citation statements)

References 31 publications

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“…Our data, assessing a strictly connection between corin and systolic and diastolic blood pressure, were also confirmed by a cross-sectional study analyzing two-thousand patients, which revealed a relationship between high serum soluble corin and prevalent hypertension [13].…”

Section: Discussionsupporting

confidence: 82%

Salt–water imbalance and fluid overload in hemodialysis patients: a pivotal role of corin

et al. 2015

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Natriuretic peptides (NP) play a key role in regulation of salt and water balance. Corin, a serine protease which activates NP, plays a key role in regulation of blood pressure and cardiac function. The aim of the study was to evaluate the involvement of corin in renal physiopathology, analyze its levels in dialyzed patients and evaluate its relation with fluid overload and comorbidities such as heart failure and blood hypertension. We studied serum corin in uremic patients (n = 20) undergoing hemodialysis therapy (HD) and in healthy subjects (HS). Corin levels in uremic patients were higher than in HS (p < 0.0001). Moreover, its concentration did not change after a single HD session. Hypertensive patients and subject suffering from heart failure were characterized by high values of corin. After multivariate analysis, direct correlations were maintained between corin and dialysis vintage (β = 0.83; p = 0.0002), heart failure (β = 0.42; p < 0.0001), systolic blood pressure (β = -0.70; p = 0.0002) and body weight (β = -0.39; p < 0.0001). Corin might be implicated in the regulation of salt and water balance and the disturbances of volume homeostasis of HD patients. However, further studies are warranted to understand the role of corin in kidney diseases and to define its diagnostic and prognostic role.

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Section: Discussionsupporting

confidence: 82%

Salt–water imbalance and fluid overload in hemodialysis patients: a pivotal role of corin

et al. 2015

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“…Blood cell analysis, including platelet count, plateletcrit, platelet distribution width, and mean platelet volume, was obtained using a BC-3200 hematology analyzer (Mindray Medical, Shenzhen, China). Fasting glucose, blood lipids including total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), and creatinine were measured by standard laboratory methods [30]. Diabetes was defined as fasting glucose over 7.0 mmol/L and/or receiving hypoglycemic medications in the last 2 weeks [31].…”

Section: Measurement Of Other Riskmentioning

confidence: 99%

Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients

Zhang

Shi

et al. 2020

International Journal of Hypertension

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Background. Platelet consumption followed by homocysteine-induced endothelial injury suggests a crosstalk between platelet activation and homocysteine on hypertension. Platelet count has been found to modify the effect of folic acid on vascular health. However, whether platelet count could modify the contribution of homocysteine to blood pressure (BP) remains unclear. Methods. Leveraging a community-based cross-sectional survey in 30,369 Chinese hypertensive patients (mean age 62 years, 52% female), we examined the moderation of platelet count on the association between serum homocysteine and BP by constructing hierarchical multiple regression models, adjusting for conventional risk factors. If adding the interaction term of homocysteine and platelet count could explain more variance in BP and the interaction is significant, then we believe that moderation is occurring. Results. e association between serum homocysteine and diastolic BP was significantly stronger (β = 0.092 vs. 0.035, P � 0.004) in participants with low platelet count (<210 × 10 9 /L) than in those with high platelet count (≥210 × 10 9 /L). Adding the interaction term of homocysteine and platelet count additionally explained 0.05% of the variance in diastolic BP (P � 0.0001), and the interaction was significant (β = − 0.021, P < 0.001). Excluding participants receiving antihypertensive medications did not change our results. Conclusions. e association between homocysteine and BP was significantly stronger in participants with low vs. high platelet count and was partially moderated by platelet count. ese results indicate that platelet count may be useful in the identification of individuals who are most beneficial to reducing-homocysteine treatments but this usefullness still needs further investigation.

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“…In a population study involving 2498 adults of more than 30 years old, increased serum corin levels were associated with hypertension [75], obesity [76], dyslipidemia [77], and hyperglycemia [78]. High levels of plasma corin were found in patients with atrial fibrillation [79].…”

Section: Plasma Soluble Corin In Heart Disease and Strokementioning

confidence: 99%

Role of corin in the regulation of blood pressure

Zhang²,

2016

Current Opinion in Nephrology and Hypertension

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Purpose of review Corin is a transmembrane protease that activates atrial natriuretic peptide (ANP), an important hormone in regulating salt-water balance and blood pressure. This review focuses on the regulation of corin function and potential roles of corin defects in hypertensive, heart, and renal diseases. Recent findings Proprotein convertase subtilisin/kexin-6 has been identified as a primary enzyme that converts zymogen corin to an active protease. Genetic variants that impair corin intracellular trafficking, cell surface expression, and zymogen activation have been found in patients with hypertension, cardiac hypertrophy, and pre-eclampsia. Reduced corin expression has been detected in animal models of cardiomyopathies and in human failing hearts. Low levels of circulating soluble corin have been reported in patients with heart disease and stroke. Corin, ANP and natriuretic peptide receptor-A mRNAs, and proteins have been colocalized in human renal segments, suggesting a corin-ANP autocrine function in the kidney. Summary Corin is a key enzyme in the natriuretic peptide system. The latest findings indicate that corin-mediated ANP production may act in a tissue-specific manner to regulate cardiovascular and renal function. Corin defects may contribute to major diseases such as hypertension, heart failure, pre-eclampsia, and kidney disease

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Association Between High Serum Soluble Corin and Hypertension: A Cross-Sectional Study in a General Population of China

Abstract: Our study showed that hypertensive participants had an increased serum corin level compared to those without hypertension. This ﬁnding suggests that corin may play a role in the pathology of hypertension.

Cited by 49 publications

References 31 publications

Salt–water imbalance and fluid overload in hemodialysis patients: a pivotal role of corin

Salt–water imbalance and fluid overload in hemodialysis patients: a pivotal role of corin

Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients

Role of corin in the regulation of blood pressure

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