Salt–water imbalance and fluid overload in hemodialysis patients: a pivotal role of corin

Abstract

Natriuretic peptides (NP) play a key role in regulation of salt and water balance. Corin, a serine protease which activates NP, plays a key role in regulation of blood pressure and cardiac function. The aim of the study was to evaluate the involvement of corin in renal physiopathology, analyze its levels in dialyzed patients and evaluate its relation with fluid overload and comorbidities such as heart failure and blood hypertension. We studied serum corin in uremic patients (n = 20) undergoing hemodialysis therapy (HD) and in healthy subjects (HS). Corin levels in uremic patients were higher than in HS (p < 0.0001). Moreover, its concentration did not change after a single HD session. Hypertensive patients and subject suffering from heart failure were characterized by high values of corin. After multivariate analysis, direct correlations were maintained between corin and dialysis vintage (β = 0.83; p = 0.0002), heart failure (β = 0.42; p < 0.0001), systolic blood pressure (β = -0.70; p = 0.0002) and body weight (β = -0.39; p < 0.0001). Corin might be implicated in the regulation of salt and water balance and the disturbances of volume homeostasis of HD patients. However, further studies are warranted to understand the role of corin in kidney diseases and to define its diagnostic and prognostic role.

Lipid disorders in patients with renal failure: Role in cardiovascular events and progression of chronic kidney disease

“…Indeed, in patients with impaired GFR values the association between higher LDL-C and risk of myocardial infarction was weak [56] . Moreover, hemodialysis patients are characterized by low LDL values associated with high cardiovascular risk, reflecting the complex puzzle constituted by several, independent and prognostic factors, such as chronic inflammation, malnutrition or vascular calcification [57] , [58] .…”

Protective Renal Effects of Atrial Natriuretic Peptide: Where Are We Now?

“…Corin is a type II transmembrane serine protease responsible for the cleavage of inactive pro-atrial natriuretic peptide (pro-ANP) into active ANP ( Ricciardi et al, 2016 ). Synthesized as a zymogen, corin needs to be cleaved by a proprotein convertase subtilisin/kexin-6 (PCSK6, also called PACE4) in order to be activated ( Chen et al, 2018 ).…”

Corin plays a protective role via upregulating MAPK and downregulating eNOS in diabetic nephropathy endothelial dysfunction

“…The reduction in Corin gene expression is likely a direct effect of diabetic hyperglycemia since high glucose also reduced Corin expression in HK-2 cells, a human kidney proximal tubular cell line. 6 Mechanistically, we showed that Corin-mediated pro-ANP processing and ANP secretion in kidney cells play a protective role in endothelial cells in a paracrine manner, suggesting that the loss of renal Corin expression seen in kidney diseases may be a pathogenic factor for endothelial dysfunction. A,B, The silencing efficiency of Corin-siRNA sequence 1 and sequence 2 in HK-2 cells was measured by real-time qPCR (n = 10 in each group) and western blot, compared with negative control-siRNA (NC-siRNA) group.…”

“…3,4 ANP plays a central role in natriuretic, diuretic, and vasodilation processes. [6][7][8] Among all tissues, Corin expression in the kidney is second only to that of the heart. [6][7][8] Among all tissues, Corin expression in the kidney is second only to that of the heart.…”