Association Between HLA‐E *0101 Homozygosity and Recurrent Miscarriage in Egyptian Women

Mosaad, Youssef M.; Abdel-Dayem, Yaser; El-Deek, Basem; El-Sherbini, Sherif M.

doi:10.1111/j.1365-3083.2011.02559.x

Cited by 21 publications

(21 citation statements)

References 26 publications

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“…Thus, the expression of HLA-E might play a role in preventing the foetus from being attacked by maternal immune system. Evidence showing lower expression of HLA-ER (0101), and its lower stability may impair its capability to downregulate NK cells and hence may be associated with RPL [146][147][148].…”

Section: Hla and Pregnancy Problemsmentioning

confidence: 99%

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Clinical Role of Human Leukocyte Antigen in Health and Disease

2015

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Most of the genes in the major histocompatibility complex (MHC) region express high polymorphism that is fundamental for their function. The most important function of human leukocyte antigen (HLA) molecule is in the induction, regulation of immune responses and the selection of the T cell repertoire. A clinician's attention is normally drawn to a system only when it malfunctions. The HLA system is no exception in this regard, but in contrast to other systems, it also arouses interest when it functions well -too well, in fact. Population studies carried out over the last several decades have identified a long list of human diseases that are significantly more common among individuals that carry particular HLA alleles including inflammatory, autoimmune and malignant disorders. HLAdisease association is the name of this phenomenon, and the mechanism underlying is still a subject of hot debate. Social behaviours are affected by HLA genes and preference for HLA disparate mates may provide 'good genes' for an individual's offspring. Also, certain HLA genes may be associated with shorter life and others with longer lifespan, but the effects depend both on the genetic background and on the environmental conditions. The following is a general overview of the important functional aspects of HLA in health and diseases.

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Section: Hla and Pregnancy Problemsmentioning

confidence: 99%

“…Several studies have focused on the distribution of these two alleles in women experiencing RPL (Table 2) [147][148][149][150][151][152]. Expression of HLA-E at the feto-maternal interface may be implicated in the successful pregnancy because of its ability to downregulate maternal immune response.…”

Section: Hla and Pregnancy Problemsmentioning

confidence: 99%

Clinical Role of Human Leukocyte Antigen in Health and Disease

2015

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“…HLA-E genotyping was determined by restriction fragment length polymorphism (RFLP) system as described previously [12]. Briefly, the known HLA-E alleles differ at only one amino acid position, with either an arginine (the HLA-E*0101) or a glycine (the HLA-E*0103) at position 107.…”

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confidence: 99%

Association of human leukocyte antigen E polymorphism with human cytomegalovirus reactivation in Chinese burn patients

Gong¹,

Ding²,

Jiang³

et al. 2013

ABBS

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“…According to Tripathi et al, HLA-E*01:01 is associated with recurrent spontaneous abortion because of decreased surface expression, lower peptide affinities and lower stability [24]. In another recent study, HLA-E*01:01 along with HLA-E*01:03 was found to be associated with RM in an Egyptian population [25].…”

Section: Hla Polymorphisms Class I Hla (Hla-g and Hla-e) Polymorphismsmentioning

confidence: 96%

Genetic factors influencing recurrent pregnancy loss: lessons learnt from recent studies

Dasgupta

Aruna

Reddy³

2012

Expert Review of Obstetrics & Gynecology

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Recurrent spontaneous abortions, also known as recurrent miscarriages (RMs), of unknown etiology provide a fundamental basis to understand the processes of embryogenesis and implantation. It is a distressing condition for the couple as well as the treating clinician. RM presents a varied etiology with a different combination of factors playing a role in its manifestation. Despite recent advances in the investigation and management of RM, a relatively large proportion of the cases remain idiopathic. An abortion is any loss before 20 gestational weeks [1]. RM is defined as the loss of two or more consecutive pregnancies spontaneously before the 24th week of gestation [2]. The modern definition, however, is the spontaneous loss of two or more consecutive pregnancies before 20 weeks of gestation [3,4]. A large number of pathological factors have been attributed to the etiology of RM, including chromosomal abnormalities, anatomic defects, immunological factors, endocrine disturbances and thrombophilia, to name a few. This has inevitably led to an understanding of the molecular genetic basis of these etiological factors, primarily with regard to the immunological and thrombophilic factors. Consequently, there has been a constant rise in the number of genetic association studies in different populations, including those from India. However, a definite conclusion on the molecular genetic etiology of RM is still lacking. In this article, we present a comprehensive review of such molecular genetic association studies based on the underlying genetic factors of three major etiologic categories in RM: immunological factors, thrombophilic factors and endocrine factors. Etiology of RM Genetic disordersChromosomal abnormalities occur in 50% of all conception products from first-trimester miscarriages, 5% of late pregnancy miscarriages and 0.5% of live births. These chromosomal anomalies could be due to aneuploidy (monosomy, trisomy and polyploidy) or structural abnormalities, such as translocations and inversions. Approximately 3% of cytogenetically abnormal conceptions are due to structural rearrangements [5]. Anatomical disordersAnatomical investigations are normally performed by hysterosalpingography, hysteroscopy or ultrasound scans. However, hysteroscopy and advanced imaging techniques (3D ultrasonography and MRI) and laparoscopy (if necessary) Recurrent miscarriage (RM) is the loss of three or more consecutive pregnancies before the 24th week of gestation. RM occurs chiefly owing to either a problem with the pregnancy or the environment where it implants and further development occurs. A large number of pathological factors have been attributed to the etiology of RM. A number of genetic association studies in different populations, including that of India, have been conducted, yet with no definite conclusions. This review analyzes various genetic association studies that have been conducted based on the underlying immunological, thrombophilic and endocrine factors in RM, and outlines the salient features of the findings an...

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Association Between HLA‐E *0101 Homozygosity and Recurrent Miscarriage in Egyptian Women

Cited by 21 publications

References 26 publications

Clinical Role of Human Leukocyte Antigen in Health and Disease

Clinical Role of Human Leukocyte Antigen in Health and Disease

Association of human leukocyte antigen E polymorphism with human cytomegalovirus reactivation in Chinese burn patients

Genetic factors influencing recurrent pregnancy loss: lessons learnt from recent studies

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