Association between homocysteine and obesity: A meta‐analysis

Wang, Jinxiang; You, Dingyun; Hua-ping, Wang; Yang, Yanhong; Zhang, Dan; Lv, Junyan; Luo, Sufeng; Liao, Rui; Ma, Lanqing

doi:10.1111/jebm.12412

Cited by 42 publications

(37 citation statements)

References 41 publications

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“…Because of the physiological decline of renal function in HCY clearance, the plasma HCY level gradually increases with age 28 . Wang J et al conducted a meta‐analysis to showed the HCY levels in obese patients is significantly higher than that in non‐obese patients 29 . This is consistent with our results.…”

Section: Discussionsupporting

confidence: 91%

Homocysteine (HCY) levels in patients with atrial fibrillation (AF): A meta‐analysis

Dong

Wang

Hou

et al. 2021

Int J Clinical Practice

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Purpose Atrial fibrillation (AF) is one of the most common persistent arrhythmia, and its complications include cerebral embolism, arterial embolism and heart failure. Some studies have found that elevated Homocysteine (HCY) levels is a new risk factor for AF. Currently, there is no meta‐analysis to explore whether the HCY levels is related to AF. Therefore, a meta‐analysis was conducted to evaluate the relationship between the HCY levels and AF, in order to draw the attention of clinicians to the HCY levels. Methods A meta‐analysis was performed in the study to evaluated the association between the HCY levels and AF. In order to identify eligible original articles, The EMBASE, PubMed, and web of science were systematically searched until November 2020. All data were analyzed with Review Manager 5.3. The meta‐analysis results were evaluated depending on standardized mean differences (SMD) with 95% confidence intervals (CI). Moreover, the subgroup analysis and sensitivity analysis were also analyzed. Results The HCY levels was significantly associated with AF (WMD = 0.81, 95% CI: 0.58 to 1.03; P < .00001). In the analysis, there was a medium degree of heterogeneity (I2 = 73%). Subgroup analysis showed that female < 60, BMI≥25, BMI <25, age ≥60 and publication year ≥2010 were identified as possible sources of heterogeneity. Sensitivity analysis showed that the main results remained unchanged after omitting any single study or converting the random effects model (REM) to fixed effects model (FEM). Conclusions The meta‐analysis showed that there is a significant correlation between the HCY levels and AF, and the role of HCY in AF patients should not be ignored in clinical.

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Section: Discussionsupporting

confidence: 91%

Homocysteine (HCY) levels in patients with atrial fibrillation (AF): A meta‐analysis

Dong

Wang

Hou

et al. 2021

Int J Clinical Practice

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“…The stimulus site was Fp2, which corresponds to the right OFC according to the 10–20 International EEG localization system. 30 The participant’s resting motor threshold (RMT) was determined before the first treatment. The RMT was measured as the lowest stimulus intensity capable of eliciting at least 5 motor responses with amplitude of at least 50 µV in a series of 10 consecutive trials of single-pulse TMS in the relaxed abductor pollicis brevis muscle.…”

Section: Methodsmentioning

confidence: 99%

Continuous Theta-Burst Stimulation Over the Right Orbitofrontal Cortex in Treatment-Resistant Obsessive-Compulsive Disorder Treatment: A Randomized Sham-Controlled Trial

Liu¹,

Shao²,

Liao³

et al. 2021

IJGM

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Purpose Examining whether modulation of right orbitofrontal cortex (OFC) activity by continuous theta-burst stimulation (cTBS) affects obsessive-compulsive disorder (OCD) symptoms. Patients and Methods A total of 28 treatment-resistant OCD participants were treated with either active or sham cTBS of the OFC twice per day, for five days a week, for 2 weeks, in a double-blinded manner. Clinical response to treatment was determined using the Yale–Brown Obsessive-Compulsive Scale (Y-BOCS). Results There were no statistically significant differences between the 2 groups after two weeks of treatment in the Yale–Brown Obsessive-Compulsive Scale score (group*time interaction, F2,20=0.996, p=0.387) and other secondary outcome measures, including anxiety symptoms and responder rates. Depressive symptoms improved significantly in the active group (p=0.027), but the significant difference disappeared at 6 weeks (p=0.089). Conclusion This is the first randomized controlled study using cTBS in the right OFC to observe the improvement of treatment-resistant OCD symptoms. It is safe to use cTBS, but 2 weeks of treatment is not enough to achieve a curative effect. Future studies are needed to explore more advanced stimulation parameters suitable for the treatment of OCD. Clinical Trial Registration www.chictr.org.cn , identifier ChiCTR2000034814.

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“…It leads to vascular dysfunction, resulting in hypertension and vascular disease, which is an independent risk factor for atherosclerosis and is closely related to the occurrence of cardiovascular and cerebrovascular diseases. Epidemiological studies have also proved [ 18 ] that the incidence of cardiovascular events in hypertensive patients with HHcy is about 5 times higher than that in pure hypertensive patients [ 18 ]. Men with H-type hypertension had an approximately 12-fold increased risk of cardiovascular events and women with H-type hypertension had an approximately 28-fold increased risk of cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Clinical Characteristics and Influencing Factors for H-Type Hypertension Complicated with Other Chronic Diseases in a Community in Beijing

Wang

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of the study is to analyze the clinical characteristics of patients with H-type hypertension complicated with other chronic diseases in a community in Beijing and to explore the influencing factors related to the occurrence of the disease by means of a case-control study. Methods. A questionnaire was designed. 362 residents with H-type hypertension in a community in Beijing were randomly enrolled from January 2020 to December 2021. The general data and clinical indexes of the patients were collected and their clinical characteristics were analyzed. According to the complications of other chronic diseases, they were divided into the simple hypertension group (n = 65) and the other chronic disease group (n = 297). Univariate and multivariate analyses were used to analyze the influencing factors for H-type hypertension patients with other chronic diseases. Results. Among the 362 H-type hypertension patients, 21 cases were aged 35–45 years, 35 cases were aged 45–55 years, and 127 cases were aged 55–65 years. The number of patients aged ≥65 years was 179, and the number of patients aged ≥55 years accounted for the highest proportion with a constituent ratio of 85.00%. Only 65 patients were patients with simple hypertension. The remaining 297 patients were complicated with different kinds of chronic diseases. The types of chronic diseases include malignant tumors, diabetes, rheumatoid arthritis, coronary heart disease, asthma, chronic obstructive pulmonary disease, systemic lupus erythematosus, and stroke. The proportion of H-type hypertension complicated with coronary heart disease, diabetes, and stroke is higher. Among the 297 patients, most of them were local, resident, and nonagricultural patients with a constituent ratio of 89.90%, 95.96%, and 98.98%, respectively. The prevalence rate of the male was 59.60% higher than that of the female at 40.40%. The blood types B and AB were more common. 90.57% of patients were married and the proportion of body mass index (BMI) was 45.79%. 60.61% of patients had a history of smoking, 55.56% had a history of drinking, 35.02% had a regular physical examination, 14.81% had regular exercise, and 37.71% had a light diet. There were significant differences in marital status, smoking, alcohol consumption, regular exercise, and light diet between the simple hypertension group and the chronic disease group ( P < 0.05 ). The results of the logistic regression analysis showed that smoking, drinking, little exercise, and not eating lightly were the independent risk factors for other chronic diseases ( P < 0.05 ). Conclusion. The incidence of H-type hypertension is higher in people ≥55 years old. Most of them are accompanied by three other chronic diseases: smoking, drinking, little exercise, and no light diet are also risk factors for chronic diseases.

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Association between homocysteine and obesity: A meta‐analysis

Cited by 42 publications

References 41 publications

Homocysteine (HCY) levels in patients with atrial fibrillation (AF): A meta‐analysis

Homocysteine (HCY) levels in patients with atrial fibrillation (AF): A meta‐analysis

Continuous Theta-Burst Stimulation Over the Right Orbitofrontal Cortex in Treatment-Resistant Obsessive-Compulsive Disorder Treatment: A Randomized Sham-Controlled Trial

Analysis of Clinical Characteristics and Influencing Factors for H-Type Hypertension Complicated with Other Chronic Diseases in a Community in Beijing

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