Association Between Homocysteine and Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis

Wang, Jinxiang; You, Dingyun; Hua-ping, Wang; Zou, Cheng‐Gang; Yang, Yanhong; Zhang, Dan; Li, Ming-Ke; Li, Chunmei; Lv, Junyan; Luo, Sufeng; Yu, Xue; Liao, Rui; Ma, Lanqing

doi:10.1007/s13410-021-00933-9

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…The antioxidants in the H. sabdariffa extract can overcome this problem. The findings of this study are consistent with other studies, which found that oxidative stress might cause hyperglycemia in experimental animals (Wang et al, 2021). HSE, on the other hand, can improve plasma glucose levels in rats.…”

Section: Discussionsupporting

confidence: 93%

CONSUMPTION OF Hibiscus sabdariffa DRIED CALYX ETHANOL EXTRACT IMPROVED REDOX IMBALANCE AND GLUCOSE PLASMA IN VITAMIN B12 RESTRICTION DIET IN RATS

Ujianti

Sianipar

Prijanti

et al. 2022

MABJ

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This study aimed to evaluate the effect of Hibiscus sabdariffa L. dried calyx ethanolic (HSE) extract on the redox imbalance and glucose plasma of vitamin B12 restriction Sprague-Dawley rats. The rat was fed a Vitamin B12 Restriction Diet for 16 weeks and treated with HSE as the treatment group. One group was fed a restriction diet not treated with HSE as a positive control group, and another was fed a control chow diet not treated with HSE as a negative control group. Vitamin B12, MDA, SOD activity enzyme, and glucose levels were evaluated in this study. The extract had a significant antioxidant capacity in terms of reducing the production of free radical scavenging activity. The HSE can repair the skewed redox imbalance and oxidative damage generated by a vitamin B12-deficient diet in the rat liver. The result of fasting glucose plasma levels, in 16 weeks showed both significantly different in all groups. In Sprague-Dawley rats with vitamin B12 restriction treated with HSE, a decrease in the glucose plasma in week sixteen was observed, together with a reduction of hepatic redox imbalance. Treatment with HSE protected hepatocytes from oxidative damage caused by vitamin B12 deficiency.

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Section: Discussionsupporting

confidence: 93%

CONSUMPTION OF Hibiscus sabdariffa DRIED CALYX ETHANOL EXTRACT IMPROVED REDOX IMBALANCE AND GLUCOSE PLASMA IN VITAMIN B12 RESTRICTION DIET IN RATS

Ujianti

Sianipar

Prijanti

et al. 2022

MABJ

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New insights into the roles of cysteine and homocysteine in pathological processes

Filip,

Constantin Pinzariu,

Aida Maranduca

et al. 2024

Biochemistry

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Both cysteine and homocysteine are sulfur-containing amino acids with distinct roles in cellular processes. This chapter explores novel perspectives on the roles of cysteine and homocysteine in pathological processes, delving into their intricate involvement in various disease pathways. Additionally, the chapter elucidates the regulatory mechanisms governing homocysteine metabolism and its implications for a range of pathological conditions, including cardiovascular diseases and neurodegenerative disorders. By synthesizing recent research findings, this chapter aims to provide fresh insights into the nuanced interplay among cysteine, homocysteine, and disease progression. The exploration of these sulfur-containing amino acids opens avenues for understanding pathophysiological mechanisms and suggests potential targets for therapeutic interventions.

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Association Between Homocysteine and Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis

Cited by 2 publications

References 49 publications

CONSUMPTION OF Hibiscus sabdariffa DRIED CALYX ETHANOL EXTRACT IMPROVED REDOX IMBALANCE AND GLUCOSE PLASMA IN VITAMIN B12 RESTRICTION DIET IN RATS

CONSUMPTION OF Hibiscus sabdariffa DRIED CALYX ETHANOL EXTRACT IMPROVED REDOX IMBALANCE AND GLUCOSE PLASMA IN VITAMIN B12 RESTRICTION DIET IN RATS

New insights into the roles of cysteine and homocysteine in pathological processes

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