Association between hypertriglyceridemic-waist phenotype and cardiovascular disease: A cohort study and meta-analysis

Zheng, Xiaowei; Ren, Xiao; Jiang, Minglan; Han, Longyang

doi:10.3389/fcvm.2022.940168

Cited by 10 publications

(18 citation statements)

References 35 publications

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“…Thus, the development of insulin resistance because of particulate matter exposure can be reflected by the TyG index. Likewise, the TyG index stands as a predictor for incident CKD [34]. Current evidence also suggested a positive relationship between TyG index and CKD in T2DM patients [13].…”

Section: Discussionmentioning

confidence: 93%

Ambient particulate matter and renal function decline in people with HIV/AIDS

Ma,

Liang,

Han

et al. 2023

Aids

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Objective: We aimed to explore the effect of particulate matter (PM) exposure on renal function in people living with HIV/AIDS (PWHA). Methods: A total of 37,739 repeated measurements were conducted on eGFR levels, serum creatinine (Scr), and the triglyceride-glucose (TyG) index in 6,958 PWHAs. The relationship between 1–28 day moving averages of PM concentrations with Scr and eGFR was assessed using linear mixed-effects models. Modified Poisson regression models were employed to assess the associations of cumulative PM exposure with the incidence of chronic kidney disease (CKD). Mediation analyses were used to examine the role of TyG index. Results: Short-term exposure to PM was related to reduced renal function. The strongest associations between exposure to PM1, PM2.5, and PM10 and percent changes in eGFR were observed at 7-day moving average exposure windows, with a respective decrease of 0.697% (−1.008%, −0.386%), 0.429% (−0.637%, −0.220%), and 0.373% (−0.581%, −0.164%) per IQR increment. Long-term exposure to PM1, PM2.5, and PM10 was positively linked with the incidence of CKD, with each IQR increment corresponding to fully adjusted RRs (95% CIs) of 1.631 (1.446, 1.839), 1.599 (1.431, 1.787), and 1.903 (1.665, 2.175), respectively. TyG index mediated 8.87%, 8.88%, and 7.58% of the relationship between cumulative exposure to PM1, PM2.5, and PM10 and increased risk of CKD, respectively. Conclusion: Exposure to PM among PWHAs is linked to reduced renal function, potentially contributing to increased CKD incidence, where the TyG index might serve as a partial mediator.

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Section: Discussionmentioning

confidence: 93%

Ambient particulate matter and renal function decline in people with HIV/AIDS

Ma,

Liang,

Han

et al. 2023

Aids

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“…Several phenotypes of the preMetS have been defined with their new corresponding indices. In a recent meta-analysis, the hypertriglyceridemic-waist (HTGW) phenotype was reported to increase the risk of CVD independent of the established risk factors 20 . Triglyceride-glucose (TyG) index which represents a quantitative value of the high triglyceride and fasting plasma glucose phenotype of traditional metabolic clusters was associated with the risk of diabetes and cardio-cerebrovascular disease even after adjusting for other MetS components 21 , 22 .…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a continuous metabolic syndrome severity score in the Tehran Lipid and Glucose Study

Honarvar

Masoumi

Mehran

et al. 2023

Sci Rep

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Metabolic syndrome (MetS), defined as the coexistence of interrelated cardiometabolic risk factors, is limited by ignoring the severity of the disease and individuals with a pre-metabolic state. We aimed to develop the first age- and sex-specific continuous MetS severity score in the adult population using confirmatory factor analysis (CFA) based on the MetS components in the Middle East. Using data from the population-based Tehran Lipid and Glucose Study (TLGS) I and II datasets, we conducted CFA of the single factor MetS on 8933 adults (20–60 years old) totally, and in age and sex subgroups. We allowed for different factor loadings across the subgroups to formulate age- and sex-specific continuous MetS severity score equations. Thereafter, we validated these equations in the dataset of TLGS III participants. Triglyceride had the highest factor loading across age and sex subgroups, indicating the most correlation with MetS. Except for women aged 40–60 years, waist circumference was the second most significant factor contributing to MetS. Systolic blood pressure was more closely related to MetS in women than in men. Systolic blood pressure and fasting plasma glucose had the weakest correlation with MetS among the 40–60 age group. Moreover, as women age, the contribution of fasting plasma glucose to MetS tended to decline, while it remained relatively constant in men. The resulting MetS severity score was correlated with age and homeostasis model assessment of insulin resistance. Furthermore, the continuous MetS severity score well predicted the traditional MetS according to receiver operating characteristic analysis in the validation dataset. The age- and sex-specific continuous MetS severity score for the West Asian adult population provides a tangible quantitative measure of MetS enabling clinicians to screen and monitor the individuals at risk and assess their metabolic trends.

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“…Several studies have investigated the association between the TyG index and renal damage in different populations 23–29 . However, there has been a limited focus on hypertensive cohorts 28,29 .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have investigated the association between the TyG index and renal damage in different populations. [23][24][25][26][27][28][29] However, there has been a limited focus on hypertensive cohorts. 28,29 A retrospective analysis conducted by Dong and colleagues involving 881 hypertensive patients, revealed that the TyG index was closely related to the occurrence and progression of early renal impairment, as assessed by measuring serum β2-microglobulin and cystatin C levels.…”

Section: Hr (95% Ci) P-valuementioning

confidence: 99%

Triglyceride glucose index and renal function decline in Han Chinese hypertensive patients

Chen,

Tsai,

Huang

2023

J of Clinical Hypertension

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Elevated triglyceride glucose (TyG) index is associated with an increased risk of cardiovascular disease. The current study aimed to investigate whether the TyG index was correlated with renal function decline in patients with hypertension. Han Chinese participants with essential hypertension were included. The TyG index was calculated as ln[fasting triglycerides (mg/dL) * fasting glucose (mg/dL)/2]. Renal function decline was defined as >25% decline in estimated glomerular filtration rate (eGFR). The Cox proportional hazard regression model was used to examine the independent effect of the TyG index on renal events. In total, 548 Han Chinese hypertensive participants with a mean age of 62.1 ± 14.3 years were eligible for enrollment. During a mean follow‐up period of 4.7 ± 3.1 years, 97 patients suffered from >25% decline in eGFR. When compared to those without eGFR decline, patients with eGFR decline had higher fasting triglyceride levels (P = .056), fasting glucose levels (P = .014), and TyG indexes (P = .014). The Cox proportional hazard regression model revealed that the TyG index (hazard ratio [HR] = 1.490; 95% confidence interval [CI] = 1.016–2.185, P = .041), office systolic blood pressure (HR = 1.013; 95% CI = 1.000–1.026, P = .047), diabetes mellitus (HR = 1.797, 95% CI = 1.026–3.147, P = .040), and baseline eGFR (HR = 1.015; 95% CI = 1.002–1.028, P = .025) were associated with renal events. In conclusions, an elevated TyG index is independently associated with an increased risk of eGFR decline in hypertensive patients.

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Association between hypertriglyceridemic-waist phenotype and cardiovascular disease: A cohort study and meta-analysis

Cited by 10 publications

References 35 publications

Ambient particulate matter and renal function decline in people with HIV/AIDS

Ambient particulate matter and renal function decline in people with HIV/AIDS

Development and validation of a continuous metabolic syndrome severity score in the Tehran Lipid and Glucose Study

Triglyceride glucose index and renal function decline in Han Chinese hypertensive patients

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