Association between TCF7L2 polymorphisms and gestational diabetes mellitus: A meta‐analysis

Abstract

Aims/IntroductionStudies have been carried out to evaluate the correlation between TCF7L2 genetic polymorphisms and gestational diabetes mellitus (GDM) risk. However, the conclusions from these studies are incomplete, because partial single nucleotide polymorphisms (SNPs) were analyzed. We carried out a meta‐analysis aimed to systematically evaluate TCF7L2 gene polymorphisms and GDM susceptibility in all population and racial/ethnic subgroups to afford a foundation for future research.Materials and MethodsPublished studies censoring TCF7L2 variants and GDM risk were captured from the EMBASE, PubMed, CNKI and Wanfang databases. The meta‐analysis was processed using software of RevMan 5.2 and Stata13. The relationship between TCF7L2 polymorphism and GDM occurrence was evaluated by pooled odds ratios. Stratified analysis based on race/ethnicity was also carried out. The allele‐specific odds ratios and 95% confidence intervals were counted, and based on homogeneity evaluated using the I 2‐test, fixed‐ or random‐effects pooled measures were selected.ResultsA total of 22 studies were covered, capturing eight TCF7L2 SNPs and involving 5,573 cases and 13,266 controls. Six of eight SNPs showed significant relationships with GDM occurrence, of which the SNPs rs7903146, rs12255372 and rs7901695 were the most powerful. Stratified analysis by race/ethnicity showed discrepant results in these three SNPs. In Caucasians and other races, all these SNPs were found to have a significant association with GDM risk, but in Asians, only SNP rs7903146 showed a significant association.ConclusionsSix of eight SNPs were found to have significant associations between TCF7L2 variants and GDM risk in the overall population, with the most powerful in SNPs being rs7903146, rs12255372 and rs7901695, but the contribution of these SNPs to GDM risk were variable among different racial/ethnic groups.

Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism

“…One of the strongest genetic predispositions for type 2 diabetes in humans is a variant of the Tcf7l2 gene [7]. Polymorphisms in Tcf7l2 have also been linked to body weight, triglyceride metabolism, and gestational diabetes [152], [153], [154]. In this study, we report that the Wnt-effector TCF7L2 is enriched in both human and mouse white adipose tissue and its expression is reduced in white adipose tissue of both genetic and diet-induced models of obesity.…”

Integrated analysis of the transcriptome-wide m6A methylome in preeclampsia and healthy control placentas

“…TCF7L2 , a transcription factor of the Wnt and Hippo signalling pathway, is hyper-methylated and up-regulated in PE, suggesting a possible positive relationship between the extent of m6A methylation and the transcript level. Earlier findings revealed that a TCF7L2 variant increased the risk of incident hypertension or diabetes mellitus ( Bonnet et al, 2013 ; Chang et al, 2017 ); however, the relationship between TCF7L2 and PE is not clear. To provide further insight, it will be necessary, in a future study, to elucidate the biological function of TCF7L2 in the context of PE.…”

Genetic variants of TCF7L2 gene and its coherence with metabolic parameters in Lithuanian (Kaunas district) women population with previously diagnosed gestational diabetes mellitus compared to general population

“…According to the literature, a higher risk of DM is indicated by TCF7L2 SNP rs7901695 C allele [21]. CC and CT alleles were combined into one group.…”

“…TCF7L2 SNP rs7903146 the risk allele for DM is T [21], so we have combined CT and TT alleles into one group. The difference between the GDM and the general population groups remained statistically significant (p = 0.008).…”