Association between indoor fungi in Delhi homes and sensitization in children with respiratory allergy

Sharma, R. L.; Gaur, Shailendra Nath; Singh, V. P.; Singh, Anand B.

doi:10.3109/13693786.2011.606850

Cited by 21 publications

(25 citation statements)

References 33 publications

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“…Local grass pollination occurred through the summer and fall, and so the sensitization rate might have progressively decreased from the highest in fall to the lowest in spring. Molds, particularly A. fumigatus , showed a significantly higher sensitization rate in the winter, consistent with previous reports26,27 that have shown that the indoor molds Penicillium and Aspergillus were dominant in indoor air in the winter.…”

Section: Discussionsupporting

confidence: 92%

Seasonal Variation in Skin Sensitivity to Aeroallergens

Choi

Lee

Myeong

et al. 2013

Allergy Asthma Immunol Res

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PurposeWe previously demonstrated seasonal variation in sensitization to aeroallergens in a small group of patients with exercise-induced asthma. This study was performed to confirm the relationship in a much larger population.MethodsThe charts of 1,891 patients who received allergy skin prick tests were reviewed retrospectively. The test results from subjects aged ≤60 years were compared between the groups classified according to the season when the patients received the tests (spring: March-May, summer: June-August, fall: September-November, winter: December-February). The data from 25 respiratory allergy patients who received the tests two or more times and showed a positive response at least once were analyzed longitudinally.ResultsThe most prevalent among 29 tested aeroallergens were house dust mites (HDMs) Dermatophagoides pteronyssinus and D. farinae. The skin sensitization rates to D. pteronyssinus (23.2% vs. 32.1%, P=0.004) and D. farinae (22.2% vs. 30.2%, P=0.009) were significantly lower in the summer and higher in the fall (38.3% vs. 26.6% and 35.6% vs. 25.3%; P=0.001 respectively) than those in other seasons in patients with a respiratory allergy (n=1,102). The sensitization rates to weed pollens in the fall (13.9% vs. 8.3%, P=0.006) and to Aspergillus fumigatus in the winter (2.9% vs. 0.7%, P=0.005) were significantly higher. In patients with non-respiratory allergy such as urticaria/anaphylaxis (n=340), the D. farinae sensitization rate was significantly lower in the summer also but higher in the spring. The trend of the HDM sensitization rate being lower in the summer and higher in the fall was observed in the longitudinal study.ConclusionsSkin sensitivity to aeroallergens such as HDMs, pollens, and molds demonstrates seasonal variation in respiratory allergy patients. Non-respiratory allergy patients also showed seasonal variation in sensitivity to aeroallergens, which might be related to the "priming" effect of allergens.

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Section: Discussionsupporting

confidence: 92%

Seasonal Variation in Skin Sensitivity to Aeroallergens

Choi

Lee

Myeong

et al. 2013

Allergy Asthma Immunol Res

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“…This can be explained by the increased exposure of aeroallergens that evoked allergen sensitization even without any genetic predisposition. Night time onset of symptoms compared to daytime onset by most of the patients is similar to earlier reports [23]. …”

Section: Discussionsupporting

confidence: 79%

“…Dampness in the living place has already been reported as one of the major causes of aeroallergen sensitization [23]. In our study, we found people who reside in damp houses (whether new or old) were more prone to allergen sensitization.…”

Section: Discussionsupporting

confidence: 65%

Sensitization to Common Aeroallergens in the Atopic Population of West Bengal, India: An Investigation by Skin Prick Test

Dey

Mondal

Laha

et al. 2018

Int Arch Allergy Immunol

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Background: Aeroallergen sensitization is increasing worldwide. The optimal management of allergic disease requires the identification of the allergic sensitivities of the patient. Complete data of offending aeroallergens are scant from West Bengal, India. Hence, we employed a retrospective analysis of an atopic population of West Bengal to investigate the rate of sensitivity toward common aeroallergens including pollens, molds and house dust mites. Objectives: The aim of the present study was to evaluate the profile of skin prick test (SPT) reactivity of an atopic population of eastern India. Methods: The prevalence aeroallergen sensitization was investigated by SPT along with a questionnaire survey of patients who visited the Allergy and Asthma Research Center of West Bengal, India, from June 2016 to May 2018. Patients were categorized according to the demographic (age, gender) and clinical aspects. Statistical tests were applied to differentiate between age and gender of the sufferers. Results: 524 out of 605 patients exhibited a positive SPT response toward one or more aeroallergens tested. One-way ANOVA following Tukey’s post hoc test reveals the age group of 15–40 years was more sensitized than that of < 15 years and no male-female discrimination was found using the paired t test. House dust mites, namely Dermatophagoides pteronyssinus and Dermatophagoides farinae, elicited most significant SPT results (80.34 and 84.92%, respectively) followed by Cocos (73.28%) and Azaridacta (57.25%) pollen. The most sensitive mold was Alternaria alternata (26.9%). Allergic rhinitis, bronchial asthma and atopic dermatitis were recorded as the common symptoms. Other influencing factors were family history, nature and season/time of onset and house conditions. Conclusion: Following the increasing trend, house dust mite sensitization still held the dominance like in any other Indian population reported earlier. This study would pave the way to construct a standard and minimal SPT panel for the atopic patients of eastern India.

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“…From a study in Delhi, a correlation between skin positivity to different fungal extracts and specific IgE to the respective fungi in the sera was recorded in the range of 33–100%. 57 However, in a study performed in the united Kingdom, the concordance rates for individual fungi varied from 14 to 56% with an average of only 40%. Highest concordance (56%) was reported for Alternaria ; and only 29% was observed for Penicillium , which is in compliance with our study.…”

Section: Discussionmentioning

confidence: 97%

Assessment of Allergenicity to Fungal Allergens of Rohtak City, Haryana, India

Kochar

Ahlawat

Dahiya

et al. 2014

Allergy�Rhinol (Providence)

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Fungal spores are known as one of the important bioparticles causing allergic manifestation in human beings. Hence, knowledge of season and prevalence of the airborne allergens to which the patients are exposed is a prerequisite for proper diagnosis and treatment of allergic disorders in hypersensitive individuals. Keeping this in view, aerial survey was performed in the atmosphere of Rohtak city for 2 consecutive years (March 2008–February 2010), using a volumetric petri plate sampler. A total of 45 fungal spore types were recorded during the survey period. In the present study, February–April and July–November were identified as the peak seasons for Rohtak city. Cladosporium was the main contributor to the total fungal load with 25.14% followed by Alternaria (18.05%), Aspergillus niger (7.66%), Curvularia (5.31%), and Epicoccum (5.29%). Fifteen dominant viable fungal spore types were represented in the form of a fungal calendar. An attempt has also been made to assess the allergenicity of some of the fungal types recorded from the atmosphere of Rohtak city. The magnitude of variations observed in markedly positive skin reactions (2+ and above) varied from 17.3 to 2.3%. Penicillium oxalicum showed a markedly positive reaction in maximum number of patients (26; 17.3%) followed by Rhizopus nigricans (23; 15.3%). ELISA was performed with the sera of patients showing markedly positive skin reactions and the sera were classified into four groups based on percent binding. The majority of the sera showed 0–15% binding to different antigenic extracts, while sera showing >60% binding were least in number. Greater than 30% binding was observed against antigens of Rhizopus nigricans, Epicoccum purpurascens, Penicillium oxalicum, Curvularia lunata, Aspergillus flavus, Candida albicans and Neurospora sitophila. The concordance between positive skin reaction and serum-specific IgE antibodies ranged from 16.7 to 69.2%.

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Association between indoor fungi in Delhi homes and sensitization in children with respiratory allergy

Cited by 21 publications

References 33 publications

Seasonal Variation in Skin Sensitivity to Aeroallergens

Seasonal Variation in Skin Sensitivity to Aeroallergens

Sensitization to Common Aeroallergens in the Atopic Population of West Bengal, India: An Investigation by Skin Prick Test

Assessment of Allergenicity to Fungal Allergens of Rohtak City, Haryana, India

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