Association between infection with <i>Helicobacter pylori</i> and atopy in young Ethiopian children: A longitudinal study

Taye, Bineyam; Enquselassie, Fikre; Tsegaye, Aster; Amberbir, Alemayehu; Medhin, Girmay; Fogarty, Andrew; Robinson, Karen; Davey, Gail

doi:10.1111/cea.12995

Cited by 22 publications

(21 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From an epidemiologic point of view, Fouda et al, who studied 90 asthmatic children and 90 healthy controls, reported a significantly lower prevalence of H. pylori in the first group (25.6% vs 44.4%) and an inverse correlation between asthma and anti‐ H. pylori IgG titers . Similar results were reported by Taye et al, who enrolled 856 Ethiopian children in their study, showing an inverse relationship between H. pylori infection, CagA positivity, and both atopy and allergic asthma . Even a meta‐analysis of data from 24 studies enrolling 1247 patients and 2410 controls by Chen et al reported an inverse relationship between H. pylori infection (OR: 0.83; 95% CI: 0.71, 0.98), CagA positivity (OR: 0.77; 95% CI: 0.66, 1.78), and allergic asthma .…”

Section: Respiratory Diseasessupporting

confidence: 56%

Helicobacter pylori and extragastric diseases

2018

View full text Add to dashboard Cite

Many studies have been performed in the last year concerning the potential role of Helicobacter pylori in different extragastric diseases, reinforcing the idea that specific microorganisms may cause diseases even far from the primary site of infection. While the role of H. pylori on idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency has been well established, there is a growing interest in other conditions, such as cardiovascular, neurologic, dermatologic, obstetric, immunologic, and metabolic diseases. Concerning neurologic diseases, there is a great interest in cognitive impairment and neurodegeneration. The aim of this review was to summarize the results of the most relevant studies published over the last year on this fascinating topic.

show abstract

Section: Respiratory Diseasessupporting

confidence: 56%

Helicobacter pylori and extragastric diseases

2018

View full text Add to dashboard Cite

show abstract

“…Interestingly, there is proof suggesting H pylori infection in fetus period may have beneficial effect. Two cohort studies provided further evidence that exposure to H pylori infection in fetal life played a protective role in the development of atopy and allergy. Inflammatory response induced by H pylori is relevant with Th1‐mediated cellular response, and the protective effect of H pylori against atopy and allergy is also mediated by secretion of regulatory T cell .…”

Section: Discussionmentioning

confidence: 99%

The risk ofHelicobacter pyloriinfection for adverse pregnancy outcomes: A systematic review and meta‐analysis

Zhan

et al. 2019

Helicobacter

View full text Add to dashboard Cite

Objective To estimate the current evidence regarding the association between Helicobacter pylori infection during pregnancy and adverse pregnancy outcomes. Materials and Methods A systematic literature search for relevant publications was conducted using PubMed, EMBASE, Cochrane Library, and Web of science databases through November 17th, 2018. The pooled odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were selected as the effect size. Subgroup analysis and sensitivity analysis were performed. Results Thirty‐one studies with a total of 22 845 participants were identified. There was significant association of H pylori infection with preeclampsia (OR: 2.51; 95% CI: 1.88‐3.34; P < 0.001), fetal growth restriction (OR: 2.28; 95% CI: 1.21‐4.32; P = 0.01), gestational diabetes mellitus (OR: 2.03; 95% CI: 1.56‐2.64; P < 0.001), spontaneous abortion (OR: 1.50; 95% CI: 1.05‐2.14; P = 0.024), and birth defect (OR: 1.63; 95% CI: 1.05‐2.54; P = 0.03). Sensitivity analysis showed the significant association between H pylori infection and low birthweight (OR: 1.59; 95% CI: 1.05‐2.40; P = 0.03). Conclusion The present meta‐analysis offers proof to support that H pylori infection during pregnancy can increase the risk on adverse pregnancy outcomes. Screening and treating for H pylori infection before pregnancy should be taken into account.

show abstract

“…Their main finding was that H. pylori infection, at any age up to 6.5 years, was associated with a lower prevalence of both atopy and any allergic condition (adjusted OR: 0.54 [95% CI: 0.32‐0.92] and 0.31 [95% CI: 0.10‐0.94], respectively). Although the authors concluded that early exposure to H. pylori was inversely associated with atopy and allergic conditions, H. pylori infection at the age of 6.5 years was inversely related to the prevalence of atopy but not significantly . This supports data from a smaller case‐control study showing a nonsignificant lower H. pylori positivity among children with allergies compared with individuals without allergies: 13.9% (17/122) vs 22.4% (22/98), respectively .…”

Section: Clinical Manifestationsmentioning

confidence: 60%

“…Ireland over a long-term follow-up period. They identified H. pylorinegative children (n = 210) in a study from 1997 to 2001 and determined their current H. pylori status by 13 C urea breath test (UBT). In addition, they also investigated the family members (n = 626), including younger siblings (n = 75), who were not included in the first study.…”

Section: Studied H Pylori Incidence Inmentioning

confidence: 99%

Helicobacter pyloriand some aspects of gut microbiota in children

2018

View full text Add to dashboard Cite

Helicobacter pylori infection in children differs from infection in adults in many aspects. The rate of infection, epidemiology, clinical presentations and complications, the applicability of diagnostic tests, antibiotic resistance, treatment options, and success rates differ significantly. Due to all these differences, management guidelines for children and adults differ also substantially. In 2017, the Updated ESPGHAN and NASPGHAN Guidelines on the management of H. pylori infection in children were published, emphasizing the differences in clinical presentation and indications for treatment, stating that the primary goal of clinical investigation in children is to identify the cause of upper gastrointestinal symptoms rather than the presence of H. pylori infection. Therefore, the diagnosis should be based on upper endoscopy, and the "test and treat strategy" should not be used in children. Due to an increasing rate of antibiotic resistance worldwide, the updated guidelines recommend broader use of antimicrobial susceptibility testing for H. pylori strains in order to tailor eradication treatment accordingly. Moreover, treatment in children should be prescribed only when indicated and should be based on the rate of eradication in local populations aiming for treatment success above 90%. During the last two decades there has been a steady decrease in the rate of H. pylori infection in both children and adults in the Western world. Two recent publications studying the incidence of H. pylori infection confirmed that early childhood is a time for acquisition of infection both in industrialized and nonindustrialized countries. In addition, they showed that H. pylori could be acquired outside the family. In respect to the inverse association between H. pylori and allergy, a longitudinal study demonstrated that early exposure to H. pylori at any age was inversely associated with atopy and allergic conditions.

show abstract

Association between infection with Helicobacter pylori and atopy in young Ethiopian children: A longitudinal study

Abstract: These data are consistent with the hypothesis that early exposure to H. pylori is inversely associated with atopy and allergic conditions. A possible modest protective association against atopy was observed in those infected with a more virulent CagA+ strain of H. pylori.

Cited by 22 publications

References 65 publications

Helicobacter pylori and extragastric diseases

Helicobacter pylori and extragastric diseases

The risk ofHelicobacter pyloriinfection for adverse pregnancy outcomes: A systematic review and meta‐analysis

Helicobacter pyloriand some aspects of gut microbiota in children

Contact Info

Product

Resources

About