The risk ofHelicobacter pyloriinfection for adverse pregnancy outcomes: A systematic review and meta‐analysis

Abstract

Objective To estimate the current evidence regarding the association between Helicobacter pylori infection during pregnancy and adverse pregnancy outcomes. Materials and Methods A systematic literature search for relevant publications was conducted using PubMed, EMBASE, Cochrane Library, and Web of science databases through November 17th, 2018. The pooled odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were selected as the effect size. Subgroup analysis and sensitivity analysis were performed. Results Thirty‐one studies with a total of 22 845 participants were identified. There was significant association of H pylori infection with preeclampsia (OR: 2.51; 95% CI: 1.88‐3.34; P < 0.001), fetal growth restriction (OR: 2.28; 95% CI: 1.21‐4.32; P = 0.01), gestational diabetes mellitus (OR: 2.03; 95% CI: 1.56‐2.64; P < 0.001), spontaneous abortion (OR: 1.50; 95% CI: 1.05‐2.14; P = 0.024), and birth defect (OR: 1.63; 95% CI: 1.05‐2.54; P = 0.03). Sensitivity analysis showed the significant association between H pylori infection and low birthweight (OR: 1.59; 95% CI: 1.05‐2.40; P = 0.03). Conclusion The present meta‐analysis offers proof to support that H pylori infection during pregnancy can increase the risk on adverse pregnancy outcomes. Screening and treating for H pylori infection before pregnancy should be taken into account.

Association betweenH. pyloriinfection and health Outcomes: an umbrella review of systematic reviews and meta-analyses

“…Overall, 3036 articles that met our search criteria were first identified from the seven databases. Sixty articles9–18 27–76 of observational studies were finally selected, covering 88 unique outcomes (figure 1). Fifty-four meta-analyses10–17 28–34 38–40 42–44 47–50 54–60 64–70 72–75 were reanalysed because they did not present all of the results of estimates (i.e.…”

“…Among the 1239 individual studies, 274 (22%) were cross-sectional studies, 748 (60%) were case–control studies, 124 (10%) were cohort studies and 93 (8%) were mentioned as observational studies. Furthermore, 1 meta-analysis62 did not present the number of participants, and 12 meta-analyses27 35 36 41 45 49 51 53 54 61–63 72 did not present the number of cases. Among the meta-analyses that indicated the number of cases or participants, the median number of cases was 1032 (28–96 753) and the median number of participants was 3826 (222–377 976).…”

“…54 Our confidence level in the following was low: H. pylori infection is associated with an increased risk of HCC, 13 biliary lithiasis, 73 PUD, 10 duodenal ulcer, 12 chronic hepatitis C, 60 non-alcoholic fatty liver disease, 63 diabetic neuropathy, 55 Parkinson's disease, 50 hyperemesis gravidarum, 45 fetal growth restriction, 72 spontaneous abortion, 72 birth defect, 72 open-angle glaucoma, 71 autoimmune thyroid diseases, 67 Grave's disease, 67 Hashimoto's thyroiditis, 67 Henoch-Schonlein purpura, 64 diabetic nephropathy, 56 gastric ulcer, 12 alcoholic cirrhosis Europeans, 33 and Sjogren's syndrome 29 ; ammonia levels decrease in patients with cirrhosis. 37 Our confidence level in the following was very low: H. pylori infection is associated with an increased risk of lung cancer, 44 cholangiocarcinoma, 14 colorectal cancer 75 , colon neoplasia, 28 chronic tonsillitis, 36 ischaemic heart disease, 47 MI, 15 coronary heart disease, 48 arrhythmia, 65 chronic bronchitis, 57 metabolic syndrome, 54 diabetes mellitus, 39 type 2 diabetes mellitus, 39 chronic atrophic gastritis, 11 dyspepsia, 9 chronic hepatitis 27 gestational diabetes mellitus, 72 gastric cancer 12 and systemic sclerosis…”

Helicobacter pyloriinfection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis

“…Although there are some ambiguous findings, research has not been carried out to address systematically the association between H. pylori infection and micronutrients deficiency in pregnant women. Previous systematic reviews have highlighted the association between H. pylori infection and negative pregnancy outcomes 20 and the association between H. pylori infection and micronutrient deficiencies in the general population. 21 Therefore, our objective was to conduct a systematic review and meta-analysis to investigate whether H. pylori infection is linked with reduced concentration of micronutrients among pregnant women, who are highly vulnerable to infection and malnutrition.…”

Türk Toplumundaki Gestasyonel Diabetes Mellitus’lu Gebelerde Helicobacter pylori Seropozitivitesi İnsidansı

“…HP'nin kronik gastrit, peptik ülser ve gastrik kanser ile ilişkisi net olarak saptanmışken, özellikle gebelik dönemindeki ekstragastrik patolojilerle korelasyonu hakkındaki literatür verisi nispeten azdır (7). Çoğunluğu kesitsel olan bu çalışmalarda, HP enfeksiyonu hiperemezis gravidarum, preeklampsi, fetal gelişme geriliği, gestasyonel diabetes mellitus (GDM), ve spontan abortusla ilişkilendirilmiştir (8)(9)(10).…”