Association between Intrapancreatic Fat Deposition and the Leptin/Ghrelin Ratio in the Fasted and Postprandial States

Abstract

<b><i>Background:</i></b> The clinical relevance of excess intrapancreatic fat deposition (IPFD) is increasingly appreciated. Leptin and ghrelin are key players in the regulation of food intake, energy balance, and body fat mass. The aim was to investigate the associations of the leptin/ghrelin ratio and its components with IPFD. <b><i>Methods:</i></b> All participants underwent magnetic resonance imaging on a 3T scanner to quantify IPFD. Both fasting and postprandial blood samples were analyzed for leptin and acylated ghrelin. Linear regression analysis was conducted, accounting for visceral/subcutaneous fat volume ratio, glycated hemoglobin, and other covariates. <b><i>Results:</i></b> A total of 94 participants (32 women) with a median age of 56 (interquartile range 44–66) years were studied. Their median IPFD was 9.6% (interquartile range 8.8–10.4%). In the fasted state, the leptin/ghrelin ratio (β = 0.354; 95% confidence interval 0.044–0.663; <i>p</i> = 0.025, in the most adjusted model) and leptin (β = 0.040; 95% confidence interval 1.003–1.078; <i>p</i> = 0.035, in the most adjusted model) were significantly associated with IPFD. Ghrelin in the fasted state was not significantly associated with IPFD. In the postprandial state, the leptin/ghrelin ratio, leptin, and ghrelin were not significantly associated with IPFD. <b><i>Conclusion:</i></b> Fasting circulating levels of leptin are directly associated with IPFD. Purposely designed mechanistic studies are warranted to determine how high leptin may contribute to excess IPFD.

Relationship between Habitual Intake of Vitamins and New-Onset Prediabetes/Diabetes after Acute Pancreatitis

“…Therefore, antidiabetic medications were included in statistical models. This study also did not assess other possible confounders (e.g., inflammatory markers, intra-pancreatic fat deposition), which may affect glucose metabolism and insulin traits following AP [ 101 , 102 , 103 , 104 , 105 , 106 ]. Due to the relatively small sample size of the present study and results not being corrected for multiple testing, there is a risk of type I error.…”

Effect of d-β-hydroxybutyrate-(R)-1,3 butanediol on plasma levels of asprosin and leptin: results from a randomised controlled trial

“…22,23 Part of the reason might be that leptin secretion varies in different adipose tissue depots 24 and its plasma levels are associated with intra-pancreatic fat deposition (IPFD) and intra-hepatic fat deposition (IHFD). [25][26][27][28][29] Taking into account the above arguments, we hypothesised that circulating levels of asprosin and leptin are altered in response to the KEβHB drink.…”

Relationship of Serum Bile Acids with Fat Deposition in the Pancreas, Liver, and Skeletal Muscle

“…4,5 Excess fat deposition in the pancreas, liver, and skeletal muscle are exemplar metabolic derangements that occur in individuals with pancreatic and liver diseases. [6][7][8][9][10][11] Further, ectopic deposition not infrequently plays an important role in the development of non-communicable diseases beyond the digestive system. [12][13][14] Bile acids are amphipathic steroid molecules synthesised in the liver from cholesterol and excreted into bile.…”