Association between Intrinsic Capacity and Sarcopenia in Hospitalized Older Patients

Zhu, Lu; Zong, Xiaofen; Shi, Xiaoming; Ouyang, Xiao

doi:10.1007/s12603-023-1946-5

Cited by 6 publications

(4 citation statements)

References 56 publications

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“…Higher IC composite scores have shown to be associated with reduced frailty and disability progression ( 40 ). Our findings revealed that 95% of pre-frail older adults experienced at least one IC domain decline, slightly surpassing the 89.9% prevalence observed in participants with sarcopenia and the 83.3% prevalence in pre-frail older adults from China at baseline ( 14 , 16 ). Notably, the proportion of pre-frail older adults with declines in individual IC domains was nearly triple that of the original ICOPE Pilot validation study in China: 75.1% compared to 25.3% in locomotion, 40.5% compared to 16.2% in vitality, 53.2% compared to 46.8% in cognition, and 41.7% compared to 12.0% in the psychological domain ( 41 ).…”

Section: Discussionmentioning

confidence: 56%

“…Sarcopenia has shown to be associated with individual IC domains such as hearing, depression, dementia, functional mobility, and vision ( 11 , 46 , 47 ). Notably, only one study has explored the association between IC composite score and sarcopenia but in hospitalized older adults whereas our study population were community dwelling older adults ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

“…Notably, the co-existance of frailty with conditions such as liver fibrosis is associated twice the risk of overall mortality ( 13 ). Frailty, sarcopenia and IC decline can co-exist in the same individual accelerating the onset of disability ( 8 , 14 ). Pre-frailty is a transition phase from robust to frailty with a prevalence rate ranging from 34.6 to 50.9% depending on the population studied and the frailty screening tools used ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

“…To date, there are limited studies on association of IC composite scores with functional ability, systemic inflammation, and sarcopenia in pre-frail older adults who are at highest risk of progressing to frailty and disability. There is only one recent study which reported association of IC with sarcopenia in hospitalized older person ( 14 ). The aim of this study is to explore association of IC composite score with functional ability, sarcopenia and systemic inflammation in pre-frail older adults.…”

Section: Introductionmentioning

confidence: 99%

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Association of intrinsic capacity with functional ability, sarcopenia and systemic inflammation in pre-frail older adults

Merchant,

Chan,

Anbarasan

et al. 2024

Front. Med.

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BackgroundDecline in intrinsic capacity (IC) has been shown to accelerate progression to disability. The study aims to explore association of IC composite score with functional ability, sarcopenia and systemic inflammation in pre-frail older adults.MethodsCross-sectional study of pre-frail older adults ≥60 years old recruited from the community and primary care centers. Composite scores of four domains of IC were measured: locomotion, vitality, cognition and psychological. FRAIL scale was used to define pre-frailty. Muscle mass was measured using the bioelectrical impedance analysis. Systemic inflammation biomarkers [Interleukin-6 (IL-6), Interleukin-10 (IL-10), Tumor Necrosis Factor Alpha (TNF-α), and Growth differentiated factor 15 (GDF-15)] were measured. Participants in the lowest tertile (T1) exhibited greater decline in IC.ResultsA total of 398 pre-frail older adults were recruited, mean age was 72.7 ± 5.8 years, 60.1% female, education level 7.8 years, and 85.2% were of Chinese ethnicity. A total of 75.1% had decline in locomotion, 40.5% in vitality, 53.2% in cognition and 41.7% in psychological domain. A total of 95% had decline in at least one domain. T1 was significantly associated with ADL impairment (aOR 3.36, 95% CI 1.78–6.32), IADL impairment (aOR 2.37, 95% CI 1.36–4.13), poor perceived health (aOR 0.96, 95% CI 0.95–0.98), fall (aOR 1.63, 95% CI 1.05–2.84), cognitive impairment (aOR 8.21, 95% CI 4.69–14.39), depression (aOR 101.82, 95% CI 33.62–308.37), and sarcopenia (aOR 2.40, 95% CI 1.60–5.45). T1 had significant associations with GDF-15, IL-10, and IL-10 to TNF-α ratio.ConclusionDecline in IC composite score among pre-frail older adults was associated with functional limitation, sarcopenia, and systemic inflammation.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of intrinsic capacity with functional ability, sarcopenia and systemic inflammation in pre-frail older adults

Merchant,

Chan,

Anbarasan

et al. 2024

Front. Med.

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Longitudinal analysis of the mediating role of self-perception of aging in the relationship between frailty and intrinsic capacity: A cross-lagged mediation model

Sun,

Zhou,

Zhang

et al. 2024

Archives of Gerontology and Geriatrics

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Association Between Intrinsic Capacity and Hospital Admission Among Older Adults in the Emergency Department

Lin,

Tseng,

Shun

et al. 2024

J Appl Gerontol

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This prospective cohort study assessed the impact of intrinsic capacity on hospital admissions among older adults after an Emergency Department (ED) visit. Assessing 1132 patients according to WHO’s Integrated Care for Older People guidelines between March 1 and August 30, 2022, we found that 784 (69.26%) were admitted. The admission group demonstrated significantly lower intrinsic capacity scores (mean ± SD, 2.92 ± 1.29) compared to the discharge group (3.44 ± 1.23; p < .001). Multivariable logistic regression showed that higher intrinsic capacity scores were associated with lower odds of admission (adjusted odds ratio [aOR] = 0.81; 95% CI: 0.71–0.92; p < .001). Notably, patients with malnutrition had significantly higher odds of admission (OR = 3.12; 95% CI: 2.16–4.50; p < .001). These findings underscore the importance of integrating the intrinsic capacity assessment with traditional clinical indicators in the emergency care of older adults.

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Association between Intrinsic Capacity and Sarcopenia in Hospitalized Older Patients

Cited by 6 publications

References 56 publications

Association of intrinsic capacity with functional ability, sarcopenia and systemic inflammation in pre-frail older adults

Association of intrinsic capacity with functional ability, sarcopenia and systemic inflammation in pre-frail older adults

Longitudinal analysis of the mediating role of self-perception of aging in the relationship between frailty and intrinsic capacity: A cross-lagged mediation model

Association Between Intrinsic Capacity and Hospital Admission Among Older Adults in the Emergency Department

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