Association Between Level of Serum Ferritin and Outcome of Patients of Stroke

Pankaj, Pranjal; Das, Medha; Singh, Manish Kumar

doi:10.14260/jemds/2015/292

Cited by 6 publications

(9 citation statements)

References 23 publications

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“…12 Egovindrajulu et al in their study observed positive correlation between serum ferritin and NIHSS scores (p=0.000). 14 In another study by Koul et al revealed that there was a significant correlation between the serum ferritin values and NIHSS (p<0.001) and modified Rankin score (p<0.001), both of which are used to evaluate the stroke severity. 13 Therefore, it is suggested that the admissionday serum ferritin correlates with the severity of stroke on admission.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of serum ferritin as a prognostic marker in acute ischemic stroke: a prospective observational study

2020

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Background: Stroke is an important health problem causing of morbidity and mortality globally. Serum ferritin has gained clinical significance as a prognostic factor that can aggravate the cytotoxicity of brain ischemia. The present study investigated the prognostic significance of serum ferritin levels with the severity of stroke using NIHSS scale.Methods: It was a prospective observational study conducted on 60 patients with acute ischemic stroke admitted in the general medicine department of a tertiary care teaching hospital. Serum ferritin levels were assessed on all participants using the instrument “immulite”. National institute of health stroke scale scoring was applied at the time of admission and on the seventh day to assess the impairment caused by a stroke. IBM SPSS version 22 was used for statistical analysis.Results: The mean serum ferritin levels at admission in patients with severe stroke, moderate stroke and mild and less stroke were 337.41±58.76, 285.56±49.37, and 197.91±111.01 ng/mL, respectively. The mean serum ferritin levels at admission were 178.76±114.70 ng/mL and 341.91±62.292 ng/mL in subjects who did not deteriorate and those who deteriorated, respectively. Whereas the mean serum ferritin levels on the sixth day were 198.34±106.88 and 348.10±57.34 ng/mL in subjects who did not deteriorate and those who deteriorated, respectively.Conclusions: Serum ferritin has a significant positive correlation with the severity of acute ischemic stroke severity on admission (p<0.001) and negative correlation with the severity of acute ischemic stroke severity on seventh day of admission (p<0.001). Thus, serum ferritin can be used as a prognostic marker in acute ischemic stroke.

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Section: Discussionmentioning

confidence: 97%

Evaluation of serum ferritin as a prognostic marker in acute ischemic stroke: a prospective observational study

2020

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“…In a similar study conducted by Pankaj et al on patients with acute ischemic stroke, the mean admission-day serum ferritin in the clinically deteriorated group (458.7 ng/mL) was significantly higher than in the clinically improved group (87.01 ng/mL). [ 1 ] Narayan and Singh observed that mean serum ferritin in deteriorated patients was 463.91 ng/mL, which was significantly higher than in those who improved (where it was only 96.44 ng/mL). [ 17 ] In another study which enrolled 51 patients with acute stroke, the serum ferritin levels were significantly higher in patients with large lesion size ( P < 0.01) and deteriorated neurologic status during clinical follow-up ( P = 0.03).…”

Section: Discussionmentioning

confidence: 99%

“…Further, during reperfusion, this tissue insult is further augmented because of reperfusion injury that causes even more iron release and even higher oxidative stress. [ 1 ] Another proposed mechanism is that brain cells with higher iron stores release more glutamate when injured during ischemia; the released glutamate in turn causes further tissue injury. [ 1 ]…”

Section: Discussionmentioning

confidence: 99%

“…Stroke or cerebrovascular accident (CVA) is defined as an abrupt-onset neurological deficit attributable to a focal vascular cause. [ 1 ] CVA is the third leading cause of death after heart diseases and cancer and is now emerging as the most common preventable life-threatening neurological problem, worldwide. [ 2 3 ]…”

Section: Introductionmentioning

confidence: 99%

“…Initially, considered only as a stress response to stroke, serum ferritin is now under research as a prognostic marker of stroke. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

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Role of serum ferritin as a prognostic marker in acute ischemic stroke: A preliminary observation

et al. 2020

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Background: Acute ischemic stroke is an important cause of morbidity and mortality. Search has been on to find out the factors which can help in formulating the prognosis of acute ischemic stroke. One of the prognostic indicators, which has gained great clinical interest in recent times, is serum ferritin. Aims: To assess the serum ferritin levels in patients with acute ischemic stroke and to study the role of serum ferritin as a prognostic marker in these patients. Materials and Methods: This prospective, observational study was conducted on 50 patients of acute ischemic stroke aged ≥18 years who presented within 48 hours of onset of symptoms. Clinical severity of stroke was assessed at admission and on the 6 th day using Canadian Stroke Scale (CSS), and serum ferritin levels were measured at admission and on the 6 th day in all these subjects. Results: The mean serum ferritin levels at admission in patients with “more severe stroke” (CSS score at admission ≤7) and “less severe stroke” (CSS score at admission >7) were 282.77 ± 120.53 and 205.12 ± 110.96 ng/mL, respectively. The mean serum ferritin levels at admission were 173.71 ± 109.69 ng/mL in subjects who did not deteriorate and 336.86 ± 57.28 ng/mL in those who deteriorated, while the mean serum ferritin levels on the 6 th day were 193.29 ± 101.88 and 343.95 ± 52.34 ng/mL in subjects who did not deteriorate and those who deteriorated, respectively. Conclusions: Serum ferritin has a significant positive correlation with the severity of acute ischemic stroke ( P < 0.001), and the levels correlate with the outcome of the disease ( P < 0.001); the patients with higher serum ferritin at admission tend to deteriorate more as compared to those with lower levels. Thus, serum ferritin can be used as a prognostic marker in acute ischemic stroke.

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Maintenance of iron homeostasis by apocynin during states of global ischemia in rat brain and retina

Kapoor

Sharma

Sandhir

et al. 2021

Advances in Redox Research

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Association Between Level of Serum Ferritin and Outcome of Patients of Stroke

Cited by 6 publications

References 23 publications

Evaluation of serum ferritin as a prognostic marker in acute ischemic stroke: a prospective observational study

Evaluation of serum ferritin as a prognostic marker in acute ischemic stroke: a prospective observational study

Role of serum ferritin as a prognostic marker in acute ischemic stroke: A preliminary observation

Maintenance of iron homeostasis by apocynin during states of global ischemia in rat brain and retina

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