Association between long noncoding RNA taurine‐upregulated gene 1 and microRNA‐377 in vitiligo

Alhelf, Maha; Rashed, Laila Ahmed; Ragab, Noura; Elmasry, Maha Fathy

doi:10.1111/ijd.15669

Cited by 17 publications

(12 citation statements)

References 59 publications

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“…However, PPAR-γ and lncRNA TUG1 were significantly downregulated in vitiligo patients. To conclude, dysregulated miRNA-377 might contribute to the pathogenesis of vitiligo through PPAR-γ downregulation and IL-17 upregulation (Alhelf et al, 2021).…”

Section: Mirna-377mentioning

confidence: 89%

“…MiR-155 upregulation might regulate the inflammatory stimuli-induced MITF-M downregulation. Elevated miRNA-377 expression might contribute to the pathogenesis of vitiligo through PPAR-γ downregulation and IL-17 upregulation (Alhelf et al, 2022). MiR-3940-5p expression was decreased in PBMCs isolated from NSV patients (Wang et al, 2015).…”

Section: Immune Imbalancementioning

confidence: 99%

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MicroRNAs: Emerging players in the pathogenesis of vitiligo

Cui

Zhu

et al. 2022

Front. Cell Dev. Biol.

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Vitiligo is an autoimmune skin disease characterized by presence of pale patchy areas of depigmentation. MicroRNAs (miRNAs) are important regulators of gene expression and play significant roles in diverse biological and pathological processes. Accumulating evidence has shown that miRNAs were differentially expressed in skin lesions and peripheral blood mononuclear cells of patients with vitiligo. In particular, miRNAs are significantly correlated with the development and progression of vitiligo. The abundance of some miRNAs in serum was also correlated with the vitiligo lesion severity, indicating that miRNAs might serve as prognostic biomarkers. Importantly, the direct involvement of miRNAs in the pathogenesis of vitiligo has been demonstrated. For example, increased expression of miR-25 contributes to vitiligo through promoting the dysfunction and oxidative stress-induced destruction of melanocytes. However, there are limited studies on the function and mechanism of deregulated miRNAs in vitiligo. Further studies are required to establish clinical applications of miRNAs for vitiligo. More in-depth investigations of miRNAs are needed for the understanding of the pathogenesis of vitiligo and the development of novel therapeutic targets. This present review summarizes the current literature on the deregulation and pathogenic roles of miRNAs in vitiligo. We also highlight the potential clinical applications of miRNAs in patients with vitiligo.

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Section: Mirna-377mentioning

confidence: 89%

Section: Immune Imbalancementioning

confidence: 99%

MicroRNAs: Emerging players in the pathogenesis of vitiligo

Cui

Zhu

et al. 2022

Front. Cell Dev. Biol.

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“…25 Studies on the role of miRNAs in vitiligo have been reported. [26][27][28][29][30][31][32] As an miRNA sponge, circRNAs can regulate gene transcription, modulate the expression of parental genes, and participate in the occurrence and development of various diseases. 33 Some circRNAs regulate inflammation, cell proliferation, and immunity of various cells involved in the pathogenesis of vitiligo, and ceRNA regulation mechanism may be involved in the oxidative stress-mediated melanocyte injury.…”

Section: Discussionmentioning

confidence: 99%

Expression Profile and Bioinformatics Analysis of Circular RNAs in Patients with Vitiligo

Zhang¹,

Zhao²,

Liao³

et al. 2022

PGPM

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Purpose Circular RNAs (circRNAs) are abundant, stable, and evolutionarily conserved noncoding RNAs with impacts on cell proliferation, differentiation, invasion, apoptosis, and immunity by acting as an miRNA sponge. This study aimed to investigate the expression of circRNAs in vitiligo and analyze the differentially expressed circRNAs (DEcircRNAs) bioinformatically. Patients and Methods Biopsies of five lesional and five nonlesional skins of patients with vitiligo and five healthy skins (control) were harvested in this study. The expression profiles of circRNAs and DEcircRNAs were determined by microarray analysis and qRT-PCR. Bioinformatics analysis was used to predict target genes of DEcircRNAs binding to miRNAs and their underlying functions. Meanwhile, a competing endogenous RNA (ceRNA) network was constructed using Cytoscape. Results A total of 817 and 508 DEcircRNAs were identified in lesional and nonlesional skins of patients with vitiligo, respectively. The results of hsa_circRNA_000957 and hsa_circRNA_101798 validation were consistent with our microarray analysis. Furthermore, 32 miRNA response elements (MREs) and related target genes of DEcircRNAs were identified, whose main functions were involved in the pathogenesis of vitiligo. Hsa_circRNA_000957 and hsa_circRNA_101798 might be candidate biomarkers for vitiligo. Conclusion This study provides scientific clues for understanding the mechanism of vitiligo.

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“…However, further processing is needed to obtain mature miRNA to work. For example, although the precursor of miR‐675 is H19, the bases of miR‐675 are mainly C and G, while the bases of H19 are mainly G, which may be the structural basis for different functions (Alhelf M, et al, 2021). Since lncRNA also has 3'UTR, miRNA can bind to 3'UTR of lncRNA just as it acts with mRNA, thus directly inhibiting lncRNA.…”

Section: Interaction Among Lncrna Mirna and Mrnamentioning

confidence: 99%