Association between long-term adherence to class-I recommended medications and risk for potentially preventable heart failure hospitalizations among younger adults

Chang, Tiffany E; Park, Soyoun; Yang, Quanhe; Loustalot, Fleetwood; Butler, Javed; Ritchey, Matthew D.

doi:10.1371/journal.pone.0222868

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…However, given the inherent limitations of DOT trials or registry data, the association between medical use and adherence could not be assessed in previous studies. The previous studies suggested that the elderly patients with chronic medical conditions were more likely to adhere to the prescribed therapy (WHO, 2003;Mantarro et al, 2015;Rashid et al, 2015;Chang et al, 2019). However, in our study, adherence to TB drugs was less common among those aged 65 or older.…”

Section: Discussioncontrasting

confidence: 72%

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Adherence and Associated Factors of Treatment Regimen in Drug-Susceptible Tuberculosis Patients

et al. 2021

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Background: Adherence to tuberculosis (TB) drugs is one of the key aspects of global TB control, yet there is a lack of epidemiological evidence on the factors influencing adherence to TB drugs. Thus, this study aimed to explore the adherence and factors associated with adherence among TB patients in South Korea.Methods: We conducted a cohort study using a sampled national healthcare database from 2017 to 2018. Our study population included incident TB patients initiating quadruple or triple regimen who were available for follow-up for 180-days. Adherence was evaluated using the proportion of days covered (PDC): 1) adherent group: patients with PDC ≥80%; 2) non-adherent group: patients with PDC <80%. Kaplan-Meier analysis was conducted to calculate the median time-to-discontinuation in the study population. We calculated the adjusted odds ratios (aOR) with 95% confidence intervals (CI) to assess factors associated with adherence to TB drugs using logistic regression.Results: Of 987 patients, 558 (56.5%) were adherent and 429 (43.5%) were non-adherent, with the overall mean PDC of 68.87% (standard deviation, 33.37%). The median time-to-discontinuation was 113 days (interquartile range 96–136) in the study population. Patients initiating quadruple regimen were more likely to adhere in comparison to the triple regimen (aOR 4.14; 95% CI 2.78–6.17), while those aged ≥65 years (aOR 0.53; 95% CI 0.35–0.81), with a history of dementia (aOR 0.53; 95% CI 0.34–0.85), and with history of diabetes mellitus (aOR 0.70; 95% CI 0.52–0.96) were less likely to adhere to the drug.Conclusion: Approximately 45% of TB patients were non-adherent to the drug, which is a major concern for the treatment outcome. We call for intensified attention from the authorities and healthcare providers to reinforce patients’ adherence to the prescribed TB drugs.

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Section: Discussioncontrasting

confidence: 72%

“…The previous studies suggested that the elderly patients with chronic medical conditions were more likely to adhere to the prescribed therapy ( WHO, 2003 ; Mantarro et al, 2015 ; Rashid et al, 2015 ; Chang et al, 2019 ). However, in our study, adherence to TB drugs was less common among those aged 65 or older.…”

Section: Discussionmentioning

confidence: 99%

Adherence and Associated Factors of Treatment Regimen in Drug-Susceptible Tuberculosis Patients

et al. 2021

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“…and 26 (35%) were related to secondary prevention (Table 1). 6,67–93 Lipid‐lowering medicines were the most commonly investigated cardiovascular medicine (36%). The majority of the scientific articles were observational studies (93%), conducted in Europe (31%) or the USA (47%), and included ≥10 000 individuals (52%).…”

Section: Resultsmentioning

confidence: 99%

Towards better reporting of the proportion of days covered method in cardiovascular medication adherence: A scoping review and new tool TEN‐SPIDERS

Dalli

Kilkenny

Arnet

et al. 2022

Brit J Clinical Pharma

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Although medication adherence is commonly measured in electronic datasets using the proportion of days covered (PDC), no standardized approach is used to calculate and report this measure. We conducted a scoping review to understand the approaches taken to calculate and report the PDC for cardiovascular medicines to develop improved guidance for researchers using this measure. After prespecifying methods in a registered protocol, we searched Ovid Medline, Embase, Scopus, CINAHL Plus and grey literature (1 July 2012 to 14 December 2020) for articles containing the terms “proportion of days covered” and “cardiovascular medicine”, or synonyms and subject headings. Of the 523 articles identified, 316 were reviewed in full and 76 were included (93% observational studies; 47% from the USA; 2 grey literature articles). In 45 articles (59%), the PDC was measured from the first dispensing/claim date. Good adherence was defined as 80% PDC in 61 articles, 56% of which contained a rationale for selecting this threshold. The following parameters, important for deriving the PDC, were often not reported/unclear: switching (53%), early refills (45%), in‐hospital supplies (45%), presupply (28%) and survival (7%). Of the 46 articles where dosing information was unavailable, 59% reported how doses were imputed. To improve the transparent and systematic reporting of the PDC, we propose the TEN‐SPIDERS tool, covering the following PDC parameters: Threshold, Eligibility criteria, Numerator and denominator, Survival, Presupply, In‐hospital supplies, Dosing, Early Refills, and Switching. Use of this tool will standardize reporting of the PDC to facilitate reliable comparisons of medication adherence estimates between studies.

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“…Chang et al (109) demostraron que la medición de la adherencia al tratamiento es un predictor de hospitalizaciones. Destacan la importancia de medir, clasificar e identificar sistemáticamente cada una las hospitalizaciones que podrían haberse evitado con una adecuada adherencia, o establecer si se hubiera podido abordar de manera eficaz desde la parte ambulatoria, para lograr hacer un control desde ese momento y al egreso hospitalario, con el fin de disminuir las tasas de readmisión y la progresión de la enfermedad.…”

Section: Evidencia De La Medición De La Adherencia En Los Pacientes C...unclassified

Relación entre nivel de adherencia al tratamiento y apoyo social en pacientes con falla cardiaca de enero a noviembre de 2020 en Bogotá

Suárez¹,

Acuña²,

Hoyos³

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Introducción: La falla cardiaca es una de las causas de hospitalización más frecuentes en la unidad de cuidado intensivo, con un alto índice de morbimortalidad. Por tal motivo, se convierte en una prioridad identificar, previamente al alta, los factores precipitantes del reingreso, siendo la adherencia al tratamiento y el apoyo social los más importantes. Objetivo: Determinar la relación entre el nivel de adherencia al tratamiento farmacológico y no farmacológico y el apoyo social de pacientes con falla cardiaca (FC). Metodología: Se realizó un estudio correlacional con un tamaño de muestra de 64 pacientes con diagnóstico de FC. Se utilizó un muestreo no probabilístico. Para la medición del nivel de adherencia se utilizó la escala para evaluación de comportamientos de adherencia con una alfa de Cronbach de 0,72, y para el apoyo social la escala Medical Outcomes Study Social Supportsurvey (MOS) con una alfa de Cronbach de 0,94. Se realizó un análisis descriptivo y se aplicó la prueba de independencia de distribuciones categóricas de Fisher para establecer la relación del nivel de adherencia con el apoyo social. Resultados: La mayoría de los participantes tenían un nivel de frecuentemente adheridos al tratamiento (78%). El índice global de apoyo social fue nivel medio (media: 76,18- DE +-16,5). Se encontró una asociación moderada entre el nivel de apoyo emocional (p: 0,006336) y apoyo afectivo (p: 0,03025) con la adherencia al tratamiento. Conclusiones: Es fundamental que el profesional de enfermería incluya la evaluación del apoyo social previamente al alta, para optimizar los niveles de adherencia. Palabras clave: Apoyo social, cumplimiento y adherencia al tratamiento, insuficiencia cardiaca (DeCS)

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Association between long-term adherence to class-I recommended medications and risk for potentially preventable heart failure hospitalizations among younger adults

Cited by 8 publications

References 37 publications

Adherence and Associated Factors of Treatment Regimen in Drug-Susceptible Tuberculosis Patients

Adherence and Associated Factors of Treatment Regimen in Drug-Susceptible Tuberculosis Patients

Towards better reporting of the proportion of days covered method in cardiovascular medication adherence: A scoping review and new tool TEN‐SPIDERS

Relación entre nivel de adherencia al tratamiento y apoyo social en pacientes con falla cardiaca de enero a noviembre de 2020 en Bogotá

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