Association Between Low-Density Lipoprotein Cholesterol and Platelet Distribution Width in Acute Ischemic Stroke

Jian, Yuan; Cai, Jingwen; Zhao, Pei; Zhao, Nan; Hong, Rongjian; Ding, Jie; Yang, Jiao; Fan, Qing-Lei; Zhu, Jian; Zhou, Xiajun; Li, Zezhi; Zhu, Dezhi; Guan, Yangtai

doi:10.3389/fneur.2021.631227

Cited by 5 publications

(7 citation statements)

References 36 publications

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“…However, due to the existence of clinical interfering factors such as exogenous PLT supplementation and blood dilution, the accuracy of PLT in predicting the prognosis of severe burns is questionable. Platelet index, such as PDW and PPR (a derivative indicator of CBC), could be used together with PLT to assess the severity of various diseases, rather than relying solely on PLT ( 15 , 25 – 27 ). In this study, we here in first found that PDW and PPR at 3 and 7 days postburn were independent risk factors for 120-day mortality in severe burn patients.…”

Section: Discussionmentioning

confidence: 99%

“…The PDW-to-PLT ratio (PPR) seems more interesting and valuable. The prognostic values of PDW and PPR have been confirmed in a variety of disease states, except for severe burn injury (15–17). In the early stages of burn injury, PLT activation and increased aggregation lead to a large consumption of PLT, and fluid resuscitation leads to blood dilution, leading to a progressive decrease in circulating PLT (18, 19).…”

Section: Introductionmentioning

confidence: 95%

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Prognostic Values of Platelet Distribution Width and Platelet Distribution Width-to-Platelet Ratio in Severe Burns

Lin

Zheng

et al. 2021

Shock

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Background: Platelet distribution width (PDW) and PDW-to-platelet ratio (PPR) have been proven to be good prognostic indicators for many diseases. However, their prognostic values in severe burns have not been reported. Objective: To investigate the early time course of PDW and PPR in severe burn patients and investigate their prognostic values. Methods: This is a 16-year, single-center retrospective study of 590 severe burn patients. The complete blood count parameters on day 1, day 3, and day 7 postburn, including PDW and PPR, were collected. Receiver operating characteristic curves (ROC) analysis, multiple logistic regression analysis and Kaplan-Meier survival analysis were performed to evaluate the prognostic values of PDW and PPR in severe burn patients. Results: According to 120-day follow-up records, 96 patients were nonsurvivors and 494 patients were survivors. ROC and area under the curve (AUC) analysis showed that, for predicting 120-day prognosis, the AUC of PDW (0.782) and PPR (0.816) on day 3 was the highest, followed by the AUC of PDW (0.764) and PPR (0.750) on day 7. The ROC-AUC of PPR (0.816) on day 3 was very close to that of the ABSI score (0.818). Multiple logistic regression analysis showed that the PDW (P ¼ 0.033 and P ¼ 0.009) and PPR (P ¼ 0.052 and P ¼ 0.046) on day 3 and day 7 were all significantly independently positively associated with 120-day mortality. Kaplan-Meier survival analysis showed that high PDW and PPR were both significantly associated with a high 120-day mortality rate on day 3 and day 7. Conclusion: PDW and PPR on day 3 and day 7 were independent risk factors for 120-day mortality in severe burn patients. These objective and readily available prognostic indicators may be more clinically favored.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Prognostic Values of Platelet Distribution Width and Platelet Distribution Width-to-Platelet Ratio in Severe Burns

Lin

Zheng

et al. 2021

Shock

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“…Recently, the association between PDW and diverse diseases, including metabolic diseases, has gained increasing attention (49). PDW is often used to estimate platelet volume heterogeneity, and the elevated PDW is highly suggestive that platelet volume is heterogeneous (50). There are even reports indicating that PDW may be more sensitive than MPV in reflecting platelet activation (51,52).…”

Section: Madan Et Al Conducted a Meta-analysis Based On 8 Studies On ...mentioning

confidence: 99%

Association between platelet indices and non-alcoholic fatty liver disease: a systematic review and meta-analysis

Li¹,

Yu²,

Zhou³

2022

Rev Esp Enferm Dig

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Background: Platelet indices have the potential for the evaluation of the activity of non-alcoholic fatty liver disease (NAFLD), but their associations are under hard debate. This meta-analysis aims to assess whether platelet count (PC), mean platelet volume (MPV) and platelet distribution width (PDW) are associated with NAFLD and its progression.Methods: A literature search was conducted using electronic databases to find publications up to July 2022, where the relationship between PC, MPV, PDW and NAFLD was evaluated. Random-effects models were applied to pool effect estimates that were presented as standardized mean differences (SMD) with 95% confidence interval (CI).Results: Nineteen studies involving 3592 NAFLD patients and 1194 healthy individuals were included. The pooled results showed that NAFLD patients had a lower PC (SMD=−0.66, 95% CI =−1.22 to −0.09, P=0.023) but a higher MPV (SMD=0.89, 95% CI=0.26-1.51, P=0.005) and PDW (SMD=0.55, 95% CI=0.11-0.99, P=0.014) compared to healthy controls. Patients with non-alcoholic steatohepatitis (NASH) exhibited a lower PC (SMD=−0.86, 95% CI=−1.20 to −0.52, P<0.001) and a higher MPV (SMD=0.71, 95% CI=0.40-1.02, P<0.001) than non-NASH individuals. A meta-regression analysis demonstrated that MPV was significantly positively correlated with aspartate aminotransferase (P=0.008), the total cholesterol (P=0.003), triglyceride (P=0.006) and low-density lipoprotein cholesterol (P=0.007), but was significantly negatively correlated with high-density lipoprotein cholesterol (P=0.010). Conclusion:This meta-analysis revealed that NAFLD patients presented a reduced PC but an increased MPV and PDW, and the changes might be associated with NAFLD severity. A higher MPV is associated with lipid metabolic disorders in NAFLD.

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“…Previous studies have indicated that MPV may serve as an independent risk factor for the onset of stroke (10,11). Additionally, some studies have also revealed a potential correlation between cerebral infarction and reduced PLT levels as well as elevated PDW levels (12)(13)(14). However, the current research on the impact of PCT on stroke has been scarcely reported.…”

Section: Introductionmentioning

confidence: 99%

The impact of platelet indices on ischemic stroke: a Mendelian randomization study and mediation analysis

Li,

Xiang,

Xue

et al. 2023

Front. Neurol.

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IntroductionPlatelet indices (PIs) are hematological parameters that indicate the number, morphology, and activation of platelets. Although some clinical trials suggest an association between PIs and the risk of stroke, the lack of robust evidence is attributed to confounding effects and reverse causation.ObjectiveThis study aimed to evaluate the association between PIs and stroke risk through Mendelian randomization (MR) while exploring the mediating effect of blood pressure in this association.MethodsWe identified genetic variants associated with PIs, including platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and platelet crit (PCT), in the UK Biobank (n = 350,474). Relevant genome-wide association studies were utilized to gather summary statistics pertaining to the traits of interest. We primarily used the inverse-variance weighted analysis to obtain estimates for individual causal power.ResultWe observed a positive correlation between genetically predicted increases in PCT levels with the stroke onset [PCT: OR (95%CI) = 1.113(1.047, 1.183), p < 0.001]. However, no significant causal relationship was found between PLT, PDW, and MPV and the risk of stroke [PLT: OR (95%CI) = 1.037(0.979, 1.098), p = 0.221; PDW: OR (95%CI) = 0.973(0.923, 1.024), p = 0.294; MPV: OR (95%CI) = 0.990(0.945, 1.038), p = 0.675]. Multivariable MR analyses and mediation analysis found that the proportion mediated by systolic blood pressure (SBP) is 23.71% [95%CI (10.85–33.31%)] and the proportion mediated by diastolic blood pressure (DBP) is 28.09% [95%CI (12.92–39.63%)].ConclusionThis large MR study presents evidence for the potential causal relationship between the PCT level and the risk of ischemic stroke, which might be mediated by blood pressure.

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Association Between Low-Density Lipoprotein Cholesterol and Platelet Distribution Width in Acute Ischemic Stroke

Cited by 5 publications

References 36 publications

Prognostic Values of Platelet Distribution Width and Platelet Distribution Width-to-Platelet Ratio in Severe Burns

Prognostic Values of Platelet Distribution Width and Platelet Distribution Width-to-Platelet Ratio in Severe Burns

Association between platelet indices and non-alcoholic fatty liver disease: a systematic review and meta-analysis

The impact of platelet indices on ischemic stroke: a Mendelian randomization study and mediation analysis

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