Association between magnesium concentration and <scp>HbA1c</scp> in children and adolescents with type 1 diabetes mellitus (儿童与青少年1型糖尿病患者的镁浓度与HbA1c之间的关系)

Galli-Tsinopoulou, Assimina; Maggana, Ioanna; Kyrgios, Ioannis; Mouzaki, Konstantina; Grammatikopoulou, Maria G.; Stylianou, Charilaos; Karavanaki, Kyriaki

doi:10.1111/1753-0407.12118

Cited by 39 publications

(34 citation statements)

References 57 publications

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“…The evidence on the association of Mg concentrations with cardiometabolic risk factors is mainly limited to studies conducted in the adult population. A recent study revealed that low serum Mg levels increases the risk of poor glycemic control in children and adolescents with type 1 diabetes [30]. Our findings on the protective role of Mg against pediatric MetS and its components are consistent with this study conducted among diabetic children and adolescents.…”

Section: Discussionsupporting

confidence: 92%

Association of Serum Concentrations of Magnesium and Some Trace Elements with Cardiometabolic Risk Factors and Liver Enzymes in Adolescents: the CASPIAN-III Study

Kelishadi

Ataei

Motlagh

et al. 2014

Biol Trace Elem Res

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This study aims to investigate the association of serum concentrations of magnesium (Mg), selenium (Se), chromium (Cr), and copper (Cu) with cardiometabolic risk factors and liver functions in Iranian children and adolescents. This case-control study was conducted under a national surveillance program. It comprised 320 students, aged 10-18 years, in two groups of equal number with or without metabolic syndrome (MetS). Serum concentrations of Mg and abovementioned trace elements were measured by atomic absorption spectrophotometry. Median regression analysis and different models of logistic regression were used to determine the associations of these elements with cardiometabolic risk factors. In the MetS group, the median of Mg, Se, Cr, and Cu was lower or equal to controls. Mg had significant inverse association with some MetS components; however, the corresponding figure was stronger for the simultaneous association of Mg, Se, Cr, and Cu with MetS components. The binary logistic regression revealed that Mg was a significant protective factor against MetS (P = 0.0001). Likewise, by considering the simultaneous association of Mg, Se, Cr, and Cu with MetS, Se was a significant protective factor against MetS. The corresponding figures were not significant for Cr and Cu. Se and Cu had significant inverse association with liver enzymes. The protective role of Mg and Se against MetS and liver enzymes, as well as the associations of these elements with some cardiometabolic risk factors and liver enzymes in the pediatric age group should be considered in future preventive and interventional studies.

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Section: Discussionsupporting

confidence: 92%

Association of Serum Concentrations of Magnesium and Some Trace Elements with Cardiometabolic Risk Factors and Liver Enzymes in Adolescents: the CASPIAN-III Study

Kelishadi

Ataei

Motlagh

et al. 2014

Biol Trace Elem Res

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“…Diabetic children had significantly lower serum magnesium level compared to control children (1.83 ± .27 mg/dL in diabetic children versus 2.00 ± .16 mg/dL in control children). Taking cut off level of serum magnesium <1.7 mg/dL for definition of hypomagnesemia, [17] hypomagnesemia was detected in 28.2% of diabetic children compared to 9.9% of control children (Table 1). There were significant differences in lipid profile parameters between diabetic and control group with lower mean value of HDL in the diabetic group versus control group with P < 0.01 and higher mean values of other lipid parameters in diabetic group versus control group with P < 0.05 (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Status of serum magnesium in Egyptian children with type 1 diabetes and its correlation to glycemic control and lipid profile

Shahbah

Naga²,

Hassan³

et al. 2016

Medicine

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Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency, having 25% to 39% prevalence. This deficit could be associated with the development of late diabetic complications, especially macroangiopathy.We aimed to evaluate the status of serum Mg in children with type 1 diabetes and assess its relation to glycemic control and lipid profile.We included 71 Egyptian children with type 1diabetes having their follow-up at Pediatric Endocrinology outpatient clinic, Zagazig University Hospital and 71 age- and sex-matched control. We measured Serum magnesium, HbA1c, and lipid profile in all study subjects.Diabetic children had significantly lower serum magnesium level compared to control children (1.83 ± .27 mg/dL in diabetic children versus 2.00 ± .16 mg/dL in control children). Taking cut-off level of serum magnesium <1.7 mg/dL for definition of hypomagnesemia, hypomagnesemia was detected in 28.2% of diabetic children compared to 9.9% of control children. In diabetic patients, there was statistically significant difference in HbA1c between hypomagnesemic and normomagnesemic group being higher in the low magnesium group, as it is mean ± SD was 11.93 ± 3.17 mg/dL in group I versus 8.92 ± 0.93 mg/dL in the normomagnesemic group. Serum magnesium was found to be positively correlated with HDL (P < 0.001), and negatively correlated with age, HbA1c, triglycerides, total cholesterol, LDL, and duration of diabetes (P < 0.001).We concluded that total serum magnesium was frequently low in Egyptian children with type 1 diabetes and it is correlated with HbA1c and with lipid profile. Hypomagnesemia was more evident in patients with poor diabetic control and those with higher atherogenic lipid parameters. We suggest that low serum magnesium may be included in pathogenesis of poor glycemic control and abnormal lipid profile in children with type 1 diabetes. We need to perform further studies on giving magnesium supplements in diabetic children with hypomagnesemia to observe the effect of correction of serum magnesium on glycemic control, lipid profile, and the risk of diabetic complications.

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“…A growing body of evidence derived from clinical trials shows that oral magnesium supplements improve insulin sensitivity and dyslipidemia in diabetic and non-diabetic individuals [7,31,36]. Insulin resistance is inversely correlated with HDLcholesterol levels and atherogenic changes characterized by low HDL-cholesterol are mainly seen in insulin-resistant subjects [37].…”

Section: Discussionmentioning

confidence: 99%

Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women

Cunha

d'El-Rei

Medeiros

et al. 2017

Journal of Hypertension

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Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women. Journal of Hypertension, 35(1), pp. 89-97.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/130809/ Condensed AbstractThis study evaluated the effects of magnesium supplementation on blood pressure (BP) and vascular function in thiazide-treated hypertensive women, mean 24-h BP≥130/80 mmHg, in a randomized, double-blind, clinical trial comparing placebo and magnesium chelate 600 mg/day supplementation. Brachial flow-mediated dilatation (FMD) and central hemodynamic parameters were measured at inclusion and after 6 months. The magnesium group demonstrated a significant reduction in systolic and diastolic BP, and a significant increase in variation of FMD versus the placebo group (+3.7±2.1 vs 2.4±1.2 %, p=0.015). In conclusion, magnesium supplementation was associated with better BP control and improved endothelial function in thiazide-treated hypertensive. AbstractEpidemiological studies demonstrate an inverse association between serum magnesium and incidence of cardiovascular disease. Diuretics commonly cause hypomagneseamia.We evaluated effects of magnesium supplementation on blood pressure (

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Association between magnesium concentration and HbA1c in children and adolescents with type 1 diabetes mellitus (儿童与青少年1型糖尿病患者的镁浓度与HbA1c之间的关系)

Abstract: The present study shows that low serum magnesium levels in children and adolescents with T1DM are associated with an increased risk of poor glycemic control, potentially contributing to the early development of cardiovascular complications.

Cited by 39 publications

References 57 publications

Association of Serum Concentrations of Magnesium and Some Trace Elements with Cardiometabolic Risk Factors and Liver Enzymes in Adolescents: the CASPIAN-III Study

Association of Serum Concentrations of Magnesium and Some Trace Elements with Cardiometabolic Risk Factors and Liver Enzymes in Adolescents: the CASPIAN-III Study

Status of serum magnesium in Egyptian children with type 1 diabetes and its correlation to glycemic control and lipid profile

Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women

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