Association between malignancies of the upper aerodigestive tract and uterine cervix

Spitz, Margaret R.; Sider, Joanne G.; Schantz, Stimson P.; Newell, Guy R.

doi:10.1002/hed.2880140502

Cited by 20 publications

(19 citation statements)

References 25 publications

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“…Consistent with this data are the increased risk for oral cancer among husbands of women with cervical cancer (9, 10) as well as the increased risk for oral cancer among women with a history of cervical cancer. (11, 12) Indeed, husband-wife pairs have been diagnosed with HPV16-positive tonsillar cancer and viral sequencing revealed the HPV16 variant to be identical in the tumors, consistent with transmission of the virus between the couple. (13)…”

Section: Introductionmentioning

confidence: 95%

Oral Human Papillomavirus Infection Before and After Treatment for Human Papillomavirus 16–Positive and Human Papillomavirus 16–Negative Head and Neck Squamous Cell Carcinoma

Agrawal

Koch

Xiao

et al. 2008

Clinical Cancer Research

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Purpose: Oral human papillomavirus (HPV) infection is a risk factor for head and neck squamous cell carcinoma (HNSCC), and is a concern for patients with HPV-positive HNSCC and their partners. The prevalence of oral HPV infection before and after cancer therapy was investigated among patients with HPV16-positive and HPV16-negative HNSCC. Experimental Design: Serial oral rinse samples (ORS) were collected from a cohort of 135 HNSCC cases as frequently as every 3 months for up to 3 years. Tumor HPV status was determined by HPV16 in situ hybridization. HPV was detected in ORS by consensus PCR and line blot hybridization.The HPV16 variants in positive oral rinse^tumor pairs were determined by sequencing. The odds of oral HPV infection among HPV16-positive and HPV16-negative cases were compared by use of generalized estimating equations. Results: Patients were followed for a median of 21months and provided a median of 4 samples. Forty-four of 135 patients had HPV16-positive tumors. HPV16-positive cases were more likely than HPV16-negative cases to have an oral HPV infection detected before (odds ratio, 8.6; 95% confidence interval, 3.5-21) and after therapy (OR, 2.9; 95% confidence interval, 1.1-7.4). Oral infections by HPV16 and other high-risk, but not low-risk, types were more common among HPV16-positive cases both before and after therapy. Most HPV16 variants in ORS were European, unique, and identical to that in the tumor. Persistence of a type-specific oral infection was demonstrable for as long as 5 years. Conclusion: Oral high-risk HPV infections are more frequent among patients with HPV16-positive than HPV16-negative HNSCC, consistent with a behavioral and/or biological disposition to infection.Case-control studies have now established that oral human papillomavirus (HPV) infection is a strong risk factor for head and neck squamous cell carcinoma (HNSCC), and particularly for oropharyngeal cancer. High-risk oral HPV infection, but not low-risk infection, is strongly associated with cancer risk (1 -3). Risk is particularly high for oral HPV16 infection. Oral HPV16 infection was independently associated with a 15-fold increase in risk for oropharyngeal cancer in a recent case-control study (4), a risk estimate similar to the 14-fold increase in subsequent risk for oropharyngeal cancer among HPV16-seropositive individuals in a nested case-control study (5).Oral HPV infection therefore has important health consequences, and yet, little is known about risk factors for infection. Limited available data suggest that oral HPV infection is likely sexually acquired: a history of sexually transmitted disease and number of oral sexual partners are associated with both oral HPV infection (6, 7) and HPV-positive oropharyngeal cancer (4). Additionally, the presence and persistence of an oral highrisk HPV infection has been associated with a persistent oral infection in a spouse (8). Consistent with these data are the increased risk for oral cancer among husbands of women with cervical cancer (9, 10) as well as the...

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Section: Introductionmentioning

confidence: 95%

Oral Human Papillomavirus Infection Before and After Treatment for Human Papillomavirus 16–Positive and Human Papillomavirus 16–Negative Head and Neck Squamous Cell Carcinoma

Agrawal

Koch

Xiao

et al. 2008

Clinical Cancer Research

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“…Other investigators have also found similar results in the past [12]. Using incidence data from Surveillance, Epidemiology & End Results (SEER), Spitz et al [15] found an elevated Standardized Incidence Ratio (SIR) for cervical cancer after an initial buccal cavity cancer and larynx cancer.…”

Section: Discussionmentioning

confidence: 65%

“…Majority (84%) of the genital cancers were in the Uterine Cervix and in more than half (68%) the genital cancer occurred before or within 6 months of development of the UADT cancer. Association between malignancies of the UADT and genital region (especially uterine cervix) has been observed by various investigators [13,15]. Hemminki et al [14] studied the pattern of second cancers in females and found a consistent increase in second HPV related cancer when the first cancer was at an HPV related site (anogenital, skin, head and neck, oesophageal and rectal cancers).…”

Section: Discussionmentioning

confidence: 99%

“…HPV transmission has been suggested to account in part for the paired occurrence of cancers at these anatomically distinct sites of UADT and cervix and smoking has been suggested as synergistic cofactor [15]. However, smokeless tobacco is a predominant form of tobacco consumed by females in India [21] and a recent study from India has shown a positive correlation of smokeless tobacco habits with cervical cancer risk [22].…”

Section: Discussionmentioning

confidence: 99%

“…HPV transmission has been suggested to account in part for the paired occurrence of cancers at these anatomically distinct sites of UADT and cervix. Exposure to tobacco carcinogens has been suggested as synergistic cofactor [15,16]. The mechanism by which HPV infection, necessary for the development of cervical cancer [17], causes UADT cancers is unclear [18].…”

Section: Introductionmentioning

confidence: 99%

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Jhavar¹,

Sarin²,

Chopra³

et al. 2005

J Carcinog

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Upper Aero digestive Tract (UADT) is the commonest site for the development of second cancer in females after primary cervical cancer. Glutathione S-transferase (GSTM1 and / or T1) null genotype modulates the risk of developing UADT cancer (primary as well as second cancer). The aim of this study was to evaluate the difference in GST null genotype frequencies in females with paired cancers in the UADT and genital region as compared to females with paired cancers in the UADT and non-genital region. Forty-nine females with a cancer in the UADT and another cancer (at all sites-genital and non-genital) were identified from a database of patients with multiple primary neoplasms and were analyzed for the GSTM1 and T1 genotype in addition to known factors such as age, tobacco habits, alcohol habits and family history of cancer. Frequencies of GSTM1 null, GSTT1 null, and either GSTM1/T1 null were higher in females with paired occurrence of cancer in the UADT and genital site (54%, 33% and 75% respectively) in comparison to females with paired occurrence of cancer in the UADT and non-genital sites (22%, 6% and 24% respectively). The significantly higher inherited frequency of either GSTM1/T1 null genotype in females with a paired occurrence of cancers in UADT and genital region (p = 0.01), suggests that these females are more susceptible to damage by carcinogens as compared to females who have UADT cancers in association with cancers at non-genital sites.

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Increased risk of second malignant neoplasms outside radiation fields in patients with cervical carcinoma

Werner‐Wasik

Schmid

Bornstein

et al. 1995

Cancer

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Background. The relative risk of second primary cancers was evaluated in 125 women with International Federation of Gynecology and Obstetrics (FIGO) Stages I and II cervical carcinoma treated radically with radiation therapy between January 1980 and December 1990. Methods. Medical records of patients were reviewed to evaluate the incidence of second malignant neoplasms. Only tumors histologically proven were scored. The annual 5‐year age‐specific cancer incidence data per 100,000 white women in the years 1981‐1985 were obtained from the National Cancer Institute's Surveillance, Epidemiology and End Results database. The relative risks were calculated as the ratio of observed‐to‐expected numbers of second cancers, using person‐years at risk accumulated for each individual in the study. Results. During the follow‐up time (through December 1992), 10 women whose median age was 65.5 years at the time cervical cancer was diagnosed were found to have 11 second primary cancers. Nine of these cancers were metachronous with regard to cervical cancer and included breast (4), lung (2), myeloma (1), non‐Hodgkin's lymphoma (1) and vulva (1). The metachronous tumors were diagnosed at a median age of 74 years and at median follow‐up time of 34 months. Two of the cancers were synchronous with cervical cancer and included bladder (1) and thyroid (1). All of the second tumors were located outside radiation fields. None of the patients with second tumors received chemotherapy during treatment for cervical carcinoma. The relative risk of developing a second cancer of any type was 2.31 (95% confidence interval [CI] = 1.15‐4.13), whereas the relative risk of developing a metachronous breast cancer was 2.64 (95% CI = 0.72‐6.75). Conclusions. An increased risk of second primary cancers developing was observed among 125 patients with FIGO Stages I and II cervical carcinoma, which may suggest an abnormal genetic background and/or a common etiology for the initial and second tumors. The increased risk of breast cancer occurring as a second primary is in contrast with previously published studies reporting a decreased risk of breast cancer in survivors of cervical cancer.

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Association between malignancies of the upper aerodigestive tract and uterine cervix

Cited by 20 publications

References 25 publications

Oral Human Papillomavirus Infection Before and After Treatment for Human Papillomavirus 16–Positive and Human Papillomavirus 16–Negative Head and Neck Squamous Cell Carcinoma

Oral Human Papillomavirus Infection Before and After Treatment for Human Papillomavirus 16–Positive and Human Papillomavirus 16–Negative Head and Neck Squamous Cell Carcinoma

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Increased risk of second malignant neoplasms outside radiation fields in patients with cervical carcinoma

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