Association between Maternal Zinc Status, Dietary Zinc Intake and Pregnancy Complications: A Systematic Review

Wilson, Rebecca L.; Grieger, Jessica A.; Bianco‐Miotto, Tina; Roberts, Claire T.

doi:10.3390/nu8100641

Cited by 87 publications

(48 citation statements)

References 110 publications

(196 reference statements)

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“…Homeostatic changes during the gestational period may result in increased zinc utilisation and mitigate immediate detrimental effects as a result of zinc deficiency [9]. The findings of a recent systematic review showed an association of low maternal dietary zinc intake with an increase in pregnancy complications [10]. In agreement, maternal zinc deficiency intensifies the danger of low birth weight and small for gestational age infants [11].…”

Section: Introductionmentioning

confidence: 99%

Selenium, Zinc, and Manganese Status in Pregnant Women and Its Relation to Maternal and Child Complications

et al. 2020

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Micronutrients, as essential components of prenatal care, are important to reduce the risk for maternal and child morbidity and mortality by lowering pregnancy-related complications. The present study aimed to investigate the status of the trace elements, i.e., selenium, zinc, and manganese in pregnant and non-pregnant women from a developing country and to evaluate its relationship with maternal and child complications. Selenium, zinc, and manganese concentrations were measured in the blood serum of 80 pregnant women and compared with 40 non-pregnant healthy controls. The quantitative analyses of trace elements were performed by using the inductively coupled plasma–optical emission spectrometry (ICP-OES) method. The information about the dietary habits of the study participants was recorded by using a food frequency questionnaire. The results showed significant lower selenium and zinc levels in pregnant women as compared to the controls (2.26 ± 1.09 vs. 2.76 ± 1.15 µmol/L, p = 0.031; 21.86 ± 7.21 vs. 29.54 ± 7.62 µmol/L, p < 0.001) respectively, with no difference in manganese concentrations (1.40 ± 0.09 vs.1.38 ± 0.09 log10 nmol/L, p = 0.365). Regarding maternal and child complications, higher manganese levels were associated with an increased odds ratio for maternal complications (OR = 3.175, CI (95%) 1.631−6.181; p = 0.038). Consumption of dairy products was associated with lower selenium and manganese values. Pregnant women showed a lower serum selenium and zinc status, and in addition elevated serum manganese concentrations, which might be associated with a higher risk for maternal pregnancy/birth complications, although more studies are necessary to evaluate this association.

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Section: Introductionmentioning

confidence: 99%

Selenium, Zinc, and Manganese Status in Pregnant Women and Its Relation to Maternal and Child Complications

et al. 2020

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“…Pregnancy is associated with modulation of Zn kinetics including increased Zn absorption and reduced loss in order to provide fetus with sufficient levels of the nutrient [50]. Although data on the association between Zn and pregnancy complications are rather contradictory [51], the existing studies demonstrate the role of altered Zn metabolism on prenatal and postnatal development [16]. Particularly, the association between Zn deficiency and fetal growth restriction [52] and neural tube defects [53] has been revealed.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Maternal Overweight on Hair Essential Trace Element and Mineral Content in Pregnant Women and Their Children

Skalny

Tinkov

Bohan

et al. 2019

Biol Trace Elem Res

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The aim of the present study was to investigate hair essential trace elements and mineral levels in 105 pregnant normal-weight (control) and 55 overweight and obese women in the third trimester of pregnancy, as well as in their children at the age of 9 months. The hair essential trace elements and mineral levels were assessed using inductively-coupled plasma mass-spectrometry. Overweight pregnant women had significantly reduced Cr (-24%; p = 0.047) and Zn (-13%; p = 0.008) content, as well as elevated hair Na and K levels as compared to the controls. Children from overweight and obese mothers had lower hair Mo (-18%; p = 0.017), Se (-8%; p = 0.043), and V (-24%; p = 0.028) levels, as well as elevated Sr content (19%; p = 0.025). Correlation analysis revealed a significant relationship between maternal and child hair levels of Co (r = 0.170; p=0.038), Cu (r = 0.513; p<0.001), Mn (r = 0.240; p=0.003), and Na (r = 0.181; p=0.027) in the whole sample. Pre-pregnancy maternal body mass index (BMI) positively correlated with maternal hair K (r = 0.336; p<0.001) and Na (r = 0.212; p=0.008), and negatively correlated with V (r =-0.204; p=0.011) and Zn (r =-0.162; p=0.045) levels. The results indicate that impaired trace element and mineral metabolism may play a role in the link between maternal obesity, complications of pregnancy and child's postnatal development. Hypothetically, dietary improvement may be used as a tool to reduce these risks. However, further experimental and clinical studies are required to investigate the relationship between obesity and trace element metabolism in pregnancy.

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“…Zinc is known as an essential element in human, plant and animal nutrition and a part of 200 metalloenzymes essential for the function of the immune system, nerves, digestion, skin and the glands (17)(18)(19). Serum and plasma zinc concentrations in adults range from 80 to150 μg/dL.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of serum zinc level as a risk factor for gastrointestinal cancers

Dizaji¹,

Babak²,

Bahadoram³

et al. 2017

Immunopathol Persa

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Introduction: Gastric adenocarcinoma and esophageal squamous cell carcinoma (ESCC) are the second and third common cancer in Iran respectively and are the leading causes of cancer deaths in the world. The status of serum zinc level in these cancers has not been fully evaluated. Objectives: The aim of the study was to compare serum zinc levels in patients with ESCC and gastric adenocarcinoma as compared to patients with other non-digestive cancers. Patients and Methods: This cross-sectional study was conducted on 100 consecutive patients (10 patients with SCC of the esophagus, 40 patients with gastric adenocarcinoma and 50 cases with other non-digestive cancers as the controls). Morning blood samples were taken containing 5 ml of blood from both groups and immediately stored in the laboratory at 8°C until all samples were taken. After collecting, serum levels of zinc in the specimens were measured by 24i chemistry analyzer. The SPSS version 23.0 for Windows was used for the statistical analysis. Results: The results of this study did not show a significant difference between mean serum level of zinc across the patients with ESCC and patients with gastric adenocarcinoma or those with other nondigestive cancers adjusted for age and gender (P > 0.05). However, a significant difference between the mean serum zinc level in patients with gastric adenocarcinoma and other non-digestive cancers was detected (P < 0.05). Conclusion: Regarding the normal serum level of zinc in other non-digestive cancers and a decrease in zinc level in gastrointestinal cancers in our study, malnutrition which is common in all malignancies, has no effect on zinc deficiency in gastrointestinal malignancies, and zinc deficiency can be considered as a primary risk factor for the development of these two digestive malignancies.

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Association between Maternal Zinc Status, Dietary Zinc Intake and Pregnancy Complications: A Systematic Review

Cited by 87 publications

References 110 publications

Selenium, Zinc, and Manganese Status in Pregnant Women and Its Relation to Maternal and Child Complications

Selenium, Zinc, and Manganese Status in Pregnant Women and Its Relation to Maternal and Child Complications

The Impact of Maternal Overweight on Hair Essential Trace Element and Mineral Content in Pregnant Women and Their Children

Evaluation of serum zinc level as a risk factor for gastrointestinal cancers

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