Association between Maximal Oxygen Uptake and the Heart Rate Corrected-QT Interval in Postmenopausal Overweight Women

Michishita, Ryoma; Shono, Naoko; Kasahara, Takashi; Tsuruta, Toshiyuki

doi:10.5551/jat.no927

Cited by 5 publications

(8 citation statements)

References 27 publications

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“…Furthermore, the QTc interval is influenced by electrolyte imbalances, such as a reduction in the outward potassium channel currents, or an increase in the inward sodium or calcium channel currents . Our previous cross‐sectional study showed that a prolonged QTc interval correlated with a lower aerobic capacity and an electrolyte imbalance . According to our previous data, a prolonged QTc interval, an electrolyte imbalance and physical activity levels were considered to show a continuous relationship.…”

Section: Discussionmentioning

confidence: 99%

“…26 Our previous cross-sectional study showed that a prolonged QTc interval correlated with a lower aerobic capacity and an electrolyte imbalance. 12 According to our previous data, a prolonged QTc interval, an electrolyte imbalance and physical activity levels were considered to show a continuous relationship.…”

Section: Discussionmentioning

confidence: 99%

“…6,10,11 Our previous cross-sectional study showed that a prolonged QTc interval correlated with a lower aerobic capacity (maximal oxygen uptake) and physical performance (muscle strength, balance and walking abilities) in postmenopausal overweight women and older adults. 12,13 However, the association between physical activity and the QTc interval is still unknown, despite the observation that physical inactivity influences the development of CAD and arrhythmias as a result of reduced muscle strength and aerobic capacity. 1,2,14 We hypothesized that a reduction of physical activity might be a sensitive factor predicting a prolonged QTc interval.…”

Section: Introductionmentioning

confidence: 99%

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Association between the physical activity and heart rate corrected‐QT interval in older adults

Michishita

Fukae

Mihara

et al. 2014

Geriatrics Gerontology Int

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between the physical activity and heart rate corrected‐QT interval in older adults

Michishita

Fukae

Mihara

et al. 2014

Geriatrics Gerontology Int

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“…At present, an electrocardiogram showing QTc prolongation is an important indicator for treatment and medication in clinical practice [ 4 ]. Many epidemiological risk factors for QTc prolongation have previously been reported, including older age, sex hormones and electrolyte disturbances [ 5 – 7 ]. Disturbances in serum electrolytes might induce or facilitate clinical arrhythmias by interacting with abnormal myocardial tissue, and this could even occur in a bundle of normal cardiac tissue.…”

Section: Introductionmentioning

confidence: 99%

Effect of serum electrolytes within normal ranges on QTc prolongation: a cross-sectional study in a Chinese rural general population

Chen

Guo

Sun

et al. 2018

BMC Cardiovasc Disord

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BackgroundMany previous clinical studies have reported that prolongation of the QT interval corrected for heart rate (QTc) is associated with an increased risk of sudden cardiac death and all-cause mortality. This study aimed to explore associations between serum electrolytes and QTc prolongation in the north-eastern Chinese rural general population.MethodsWe performed a cross-sectional study including 10,334 (4820 men and 5514 women) from the general population aged ≥35 years in the Liaoning Province from 2012 to 2013. Anthropometric measurements, laboratory examinations and self-reported lifestyle factor information, echocardiography and electrocardiogram were collected by trained personnel. The associations between serum electrolytes and QTc prolongation were tested using multiple linear regression and logistic regression analyses.ResultsThe mean QTc interval were 415.6 ± 18.8 and 470.1 ± 23.1 ms in normal group and QTc prolongation group respectively. The prevalence of QTc prolongation increased significantly with a decrease in serum potassium and an increase in magnesium. Stepwise multiple linear regression showed that age, hypertension, waist circumference were prominently positive associated with QTc interval both in male and female population. But serum potassium was significantly inversely associated with QTc interval. Serum magnesium and calcium also showed a positive relationship with QTc interval. Furthermore, multiple logistic regression found that lower quartile of serum potassium had higher risk for QTc prolongation, especially in female population (Q2 vs. Q4: OR: 1.54, 95%CI: 1.01–2.35; Q1 vs. Q4: OR: 2.02, 95%CI: 1.36–3.01). In addition, the higher serum magnesium increased the risk of QTc prolongation, which was significantly only in male population.ConclusionsIn present Chinese rural general population, even with normal range, a decrease in serum potassium and an increase in serum magnesium are important risk factors for QTc prolongation.Electronic supplementary materialThe online version of this article (10.1186/s12872-018-0906-1) contains supplementary material, which is available to authorized users.

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“…Our previous cross-sectional study (28) noted that a prolonged QTc interval correlated negatively with a lower aerobic capacity, while it positively correlated with the serum sodium level and negatively correlated with the serum potassium concentration in postmenopausal overweight females. Moreover, Franzoni et al (29) reported that patients with anorexia nervosa have a greater QT dispersion than normal body weight females, and oral potassium supplementation (two vials of K-Flebo d , per os) for 4 wk led to a significant reduction in the QT interval dispersion.…”

Section: Discussionmentioning

confidence: 84%

Influence of Dietary Sodium and Potassium Intake on the Heart Rate Corrected-QT Interval in Elderly Subjects

Michishita

Ishikawa-Takata

Yoshimura

et al. 2015

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary It is well known that imbalances in the dietary electrolytes are associated with a significantly higher incidence of cardiovascular disease (CVD). On the other hand, a prolonged heart rate corrected-QT (QTc) interval is associated with an increased risk of cardiac autonomic nervous system dysfunction, the incidence of CVD and sudden cardiac death. This study was designed to clarify the association between the nutritional status and the QTc interval in elderly subjects. The subjects included 119 elderly subjects (46 males and 73 females, age; 72.964.8 y) without a history of CVD, who were taking cardioactive drugs. Resting 12-lead electrocardiography was performed, while the QTc interval was calculated according to Bazett's formula. The nutritional status was assessed using a brief self-administered diet history questionnaire. The subjects were divided into three categories, which were defined as equally trisected distributions of the body mass index (BMI). The QTc interval was significantly longer in both the low and high BMI groups than in the moderate BMI group in both genders (p,0.05, respectively). A stepwise multiple regression analysis showed the QTc interval to be independently associated with the potassium intake in the low BMI group and the sodium intake in the high BMI group in both genders (p,0.05, respectively). These results suggest that the body mass, especially lean body mass and overweight, were associated with a prolonged QTc interval and dietary electrolytes in elderly subjects. Based on our results, we consider that it is necessary to perform dietary counseling, especially focusing on sodium and potassium intake, depending on the body mass.

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Association between Maximal Oxygen Uptake and the Heart Rate Corrected-QT Interval in Postmenopausal Overweight Women

Abstract: Background: Increased aerobic capacity can reduce the incidence of cardiovascular disease and the mortality rate. On the other hand, a prolonged heart rate corrected-QT (QTc) interval is associated with an increased risk of arrhythmias, cardiac sudden death and coronary artery disease.

Cited by 5 publications

References 27 publications

Association between the physical activity and heart rate corrected‐QT interval in older adults

Association between the physical activity and heart rate corrected‐QT interval in older adults

Effect of serum electrolytes within normal ranges on QTc prolongation: a cross-sectional study in a Chinese rural general population

Influence of Dietary Sodium and Potassium Intake on the Heart Rate Corrected-QT Interval in Elderly Subjects

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