Association between menopausal state and prognosis of endometrial cancer

Abstract

The purpose of our study was to examine the menopausal state as an independent prognostic variable of endometrial cancer and determine the conditions under which the menopausal state would be an independent prognostic variable of such cancer. We studied the clinical and pathologic variables of 255 patients with invasive endometrial cancer. In comparisons of the clinicopathologic variables between menopausal states, obesity and deep myometrial invasion were found more frequently in older patients than in younger ones. Multivariate analysis performed on 255 cases with complete pathologic data identified menopausal state, cervical invasion, pelvic lymph node metastasis, and tumor grade as prognostic variables. Univariate analysis revealed that survival of older patients with FIGO pathologic stage Ib disease was significantly poorer than in younger patients, while there was no significant difference in the analyses of stage Ic or advanced disease beyond stage II. We conclude that menopausal state was an independent prognostic variable for patients with early endometrial cancer, but not for patients with advanced disease.

Identification of risk factors for the prognosis of Chinese patients with endometrial carcinoma

“…Compared with endometrial cancer patients over 45 years old, patients under 45 years old had lower staging, lower histological grade, and a better prognosis [4] . Nakanishi et al reported similar results [5] . However, another study showed no significant difference in clinical staging and histological type between endometrial cancer patients under 45 years old and elderly patients [6] .…”

“…[ 4 ] Nakanishi et al reported similar results. [ 5 ] However, another study showed no significant difference in clinical staging and histological type between endometrial cancer patients under 45 years old and elderly patients. [ 6 ] The pathogenesis of endometrial carcinoma in postmenopausal women may be different from that in premenopausal women, and the prognosis is worse than that of postmenopausal women.…”

Prognostic factors in endometrial cancer

“…17 Both univariate and multivariate analysis showed there was D VLJQL¿FDQW FRUUHODWLRQ EHWZHHQ P\RPHWULDO LQYDVLRQ DV prognostic factors. In endometrial carcinomas the depth of myometrial invasion has been shown to be an independent predictor of outcome.…”

Polycystic Ovary Syndrome and Endometrial Cancer

“…None had a recurrence over 5 years. Nakanishi et al 38 in a study of 255 patients with invasive endometrial cancer, commented on 120 cases in a younger (premenopausal) group in comparison with 135 cases in an older (postmenopausal) group. The authors concluded that in the premenopausal group (age as an independent prognostic variable), the prognosis was better for early invasive disease but that the menopausal state was irrelevant for deeply invasive or advanced endometrial cancer.…”