Association between metabolic syndrome and vascular endothelium dysfunction in children and adolescents

Ying, Wei; Liu, G L; Yang, Ju Young; Ruan, Zheng; Jiang, Ling; Li, Y P; Gao, Fang

doi:10.4238/2014.october.27.7

Cited by 14 publications

(15 citation statements)

References 24 publications

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“…Numerous harmful stimuli can lead to endothelial cell dysfunction (ECD) with consequential increases in the risk of many diseases including cardiovascular diseases (Vykoukal and Davies, 2011;Khaddaj Mallat et al, 2017; Kaplan et al, 2018;Maiuolo et al, 2020a). In MetS patients, the ECD is a specific early pathophysiological indicator of cardiovascular disorders; its recognition and early intervention are of extreme importance in the prevention, treatment, and prognosis of cardiovascular diseases (Wei et al, 2014;Dalal et al, 2020). In particular, many substances secreted by VEC are considered important indicators of the function of endothelial cells, these include: Plasminogen Activator Inhibitor-1 (PAI-1), von Willebrand factor (vWF), vascular endothelial cadherin (VE-cad), Thrombomodulin (TM), and Vascular endothelial growth factor (VEGF).…”

Section: The Role Of the Endothelium In Metabolic Syndromementioning

confidence: 99%

“…Scientific studies have shown that serum levels of PAI-1, vWF, VE-cad, TM, and VEGF were increased in patients with MetS compared to healthy individuals (Georgieva et al, 2004;Hajiluian et al, 2017;Mazidi et al, 2017;Wang et al, 2018). Moreover, an increase has also been found in children and adolescents with MetS, evidencing that these parameters can be considered predictors of early vascular changes (Wei et al, 2014). MetS negatively affects the function of the vascular endothelium; increasing vasoconstriction and prothrombotic state through different mechanisms (Aggoun, 2007;O'Shea et al, 2015;Pomero et al, 2015;Domingueti et al, 2016):…”

Section: The Role Of the Endothelium In Metabolic Syndromementioning

confidence: 99%

“…• Carbohydrate metabolism (hyperinsulinemia/insulin resistance or hyperglycemia/diabetes), dyslipidemia, obesity, and hypertension can all determine vascular contractility (Cuspidi et al, 2018). • Altered carbohydrate metabolism, dyslipidemia, hypertension, and obesity lead to increased PAI-1, vWF, VE-cad, TM, and VEGF production; a condition responsible for impaired anticoagulant and fibrinolytic activity which can cause hypercoagulability: a low fibrinolytic and high viscosity state, and promote the formation of microthrombi (Wei et al, 2014).…”

Section: The Role Of the Endothelium In Metabolic Syndromementioning

confidence: 99%

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From Metabolic Syndrome to Neurological Diseases: Role of Autophagy

Maiuolo

Gliozzi

Musolino

et al. 2021

Front. Cell Dev. Biol.

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Metabolic syndrome is not a single pathology, but a constellation of cardiovascular disease risk factors including: central and abdominal obesity, systemic hypertension, insulin resistance (or type 2 diabetes mellitus), and atherogenic dyslipidemia. The global incidence of Metabolic syndrome is estimated to be about one quarter of the world population; for this reason, it would be desirable to better understand the underlying mechanisms involved in order to develop treatments that can reduce or eliminate the damage caused. The effects of Metabolic syndrome are multiple and wide ranging; some of which have an impact on the central nervous system and cause neurological and neurodegenerative diseases. Autophagy is a catabolic intracellular process, essential for the recycling of cytoplasmic materials and for the degradation of damaged cellular organelle. Therefore, autophagy is primarily a cytoprotective mechanism; even if excessive cellular degradation can be detrimental. To date, it is known that systemic autophagic insufficiency is able to cause metabolic balance deterioration and facilitate the onset of metabolic syndrome. This review aims to highlight the current state of knowledge regarding the connection between metabolic syndrome and the onset of several neurological diseases related to it. Furthermore, since autophagy has been found to be of particular importance in metabolic disorders, the probable involvement of this degradative process is assumed to be responsible for the attenuation of neurological disorders resulting from metabolic syndrome.

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Section: The Role Of the Endothelium In Metabolic Syndromementioning

confidence: 99%

Section: The Role Of the Endothelium In Metabolic Syndromementioning

confidence: 99%

Section: The Role Of the Endothelium In Metabolic Syndromementioning

confidence: 99%

See 1 more Smart Citation

From Metabolic Syndrome to Neurological Diseases: Role of Autophagy

Maiuolo

Gliozzi

Musolino

et al. 2021

Front. Cell Dev. Biol.

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“…Various studies indicated that endothelial cell dysfunction is an early pathophysiological indicator of cardiovascular diseases (CVD). VEGF, among other substances, is secreted by the vascular endothelium and could be a substantial indicator of endothelial cell function [26]. Different signalling pathways are activated by the binding of VEGF to their corresponding receptors [27].…”

Section: Discussionmentioning

confidence: 99%

Serum Vascular Endothelial Growth Factor in Egyptian Obese Women with Insulin Resistance

Zaki¹,

Basha²,

Yousef³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Obesity is a major factor in the development of several sub-clinical anomalies. Insulin resistance (IR) is associated with obesity. Vascular endothelial growth factor (VEGF) plays a significant role in inflammation and vascular neogenesis. However the precise relationships of its levels with clinical, lipid, and metabolic profiles are unknown. AIM: This study aimed to examine the association between serum VEGF concentrations with IR risk and metabolic and lipid parameters in obese women. METHODS: Serum VEGF, metabolic biomarkers and anthropometry were measured in 83 obese women with IR and 50 healthy women. Fat distributions in the abdominal, subcutaneous and visceral area were assessed. Homeostasis model assessment for insulin resistance index (HOMA-IR) was calculated. For analytical purposes, VEGF levels were categorised into three tertiles groups. RESULTS: Obese women with IR showed significantly higher levels of serum VEGF as compared with the control group. Moreover, obese women in the highest VEGF tertile had significantly higher values of obesity indices, visceral fat index, abnormal lipid levels and HOMA-IR compared to with those in the lower tertile. CONCLUSION: Elevated VEGF levels are associated with IR and high visceral fat index in obese women which in turn increased the risk for metabolic complications.

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“…Other health conditions such as insulin resistance and diabetes cause associated medical complications in obese patients [3,4,5,6].…”

Section: Introductionmentioning

confidence: 99%

Coexistence of endothelial dysfunction, fibrinolysis activation and diminished interleukin 6 level in morbid obesity

Iwan-Ziętek

Szot

Michalska

et al. 2018

Pomeranian J Life Sci

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ABSTRAKTWstęp: Celem pracy była ocena wybranych parametrów dysfunkcji śródbłonka i hemostazy u chorych z otyłością. Badania dotyczące zaburzeń komórek śródbłonka w otyłości ogromnej są w literaturze spotykane zaskakująco rzadko.Materiały i metody: Badanie przeprowadzono u 74 chorych z otyłością ze wskaźnikiem masy ciała (BMI) >40 kg/m2 oraz u 30 zdrowych ochotników z prawidłowym BMI. W osoczu krwi chorych przeprowadzono testy stężenia: rozpuszczalnej formy trombomoduliny (sTM), antygenu czynnika von Willebranda (vWF:Ag), antygenu tkankowego aktywatora plazminogenu (t-PA:Ag) i antygenu inhibitora aktywatora plazminogenu typu 1 (PAI-1:Ag) oraz rozpuszczalnej frakcji selektyny E i P (sE-selektyny i sP-selektyny). Dokonano także pomiaru stężenia interleukiny 6 (Il-6).Wyniki: Wyniki badań wskazały znaczne zwiększenie stężenia sTM, t-PA:Ag, PAI-1:Ag i sE-selektyny oraz istotne zmniejszone stężenie vWF:Ag i sP-selektyny w otyłości ogromnej w porównaniu z grupą kontrolną. Wykazano także w otyłości ogromnej obniżenie stężenia Il-6.Wnioski: W otyłości ogromnej dochodzi do uszkodzenia śródbłonka, co zwiększa ryzyko ewentualnych powikłań zakrzepowo-zatorowych. Zwiększenie składowych układu fibrynolizy oraz hamowanie aktywacji płytek można traktować jako mechanizmy kompensacyjne zmniejszające ryzyko powikłań. Spadek stężenia Il-6 może być wyrazem ograniczania procesu zapalnego, ale równocześnie może to być przyczyna zwiększonej podatności na choroby infekcyjne.

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Association between metabolic syndrome and vascular endothelium dysfunction in children and adolescents

Cited by 14 publications

References 24 publications

From Metabolic Syndrome to Neurological Diseases: Role of Autophagy

From Metabolic Syndrome to Neurological Diseases: Role of Autophagy

Serum Vascular Endothelial Growth Factor in Egyptian Obese Women with Insulin Resistance

Coexistence of endothelial dysfunction, fibrinolysis activation and diminished interleukin 6 level in morbid obesity

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