Association between Metabolic Syndrome and Hepatitis B Virus Infection in the Roma Population in Eastern Slovakia: a Population-Based Study

Janíčko, Martin; Senajová, Gabriela; Dražilová, Sylvia; Veselíny, Eduard; Fedačko, Ján; Siegfried, Leonard; Kristián, Pavol; Virág, Ladislav; Pella, Daniel; Mareková, Mária; Gecková, Andrea Madarasová; Kalanin, Peter; Jarčuška, Peter; Halánová, Monika

doi:10.21101/cejph.a3900

Cited by 17 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study group included only adults and as such, the prevalence of HBV infection among our study group was slightly higher than the prevalence for the general population. The relationship between HBV and MetS remains inconclusive [10][11][12][13][14][15][16][17][18] , with some studies reporting a protective effect of HBsAg seropositivity against MetS while other studies found no association between HBsAg positivity and MetS 20 . It is important to note, however, that most studies regarding the association between HBV and MetS have been performed in Taiwan, Japan, Korea, Slovakia and the United States, with few studies having been conducted in China.…”

Section: Discussionmentioning

confidence: 99%

Association between Hepatitis B Virus Infection and Metabolic Syndrome in Southwest China: A Cross-sectional Study

Yan

Liao

Han

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Hong tang 1 ✉ the correlation between hepatitis B virus (HBV) infection and metabolic syndrome (MetS) remains to be clarified. In this study, we explored this association in a large population in Southwest China. This was a cross-sectional study, with pooled adult health data. Multivariate logistic regression analysis, controlling for age, sex, HBV status, alanine aminotransferase, and fatty liver, was used to identify predictor(s) of MetS. Of the 96,175 participants, positive HBV was identified in 7984 (8.30%) and MetS in 12,092 (12.57%). The MetS prevalence was lower among HBV positive than negative individuals (11.64% versus 12.66%, P < 0.001). The adjusted odds (aOR) of positive HBV among individuals with MetS was 0.841 (95% confidence interval (CI), 0.771-0.916) in men and 0.834 (95% CI, 0.672-0.925) in women. Elevated triglyceride level, a component of MetS, was inversely associated with HBV status in both men and women: aOR, 0.551 (95% CI, 0.514-0.590) and 0.683 (95% CI, 0.605-0.769), respectively. Among HBV positive individuals, liver cirrhosis was more common among those with than without MetS (4.83% versus 2.93%, respectively; P = 0.002). HBsAg-seropositive are inversely associated with MetS, especially elevated triglycerides. Liver cirrhosis was more common among HBV infection patients with MetS. Chronic hepatitis B virus (HBV) infection is a major public health issue 1. HBV infection is not only the cause of acute and chronic hepatitis, but is also one of the key etiological factors of liver cirrhosis and hepatocellular carcinoma (HCC). In 2015, it was estimated that 257 million people, 3.5% of the world's population, were living with a chronic HBV infection 2. In China, a HBV-endemic region, the prevalence of HBV infection for population among individual 1 to 59 years of age is approximately 7.18%, with an estimated 93 million patients individuals in China living with a chronic HBV infection 3. Although the health morbidities of chronic HBV infection are decreasing, these remain a tremendous healthcare burden in China. Considering that the liver plays a key role in glucose homeostasis and lipid metabolism, the possible association between liver disease and diabetes mellitus or metabolic syndrome (MetS) has been a topic of healthcare research interest. MetS refers to diseases caused by metabolic disturbances, such as increased waist circumference, hyperglycemia, elevated blood pressure (BP), and dyslipidemia. MetS affects approximately one-fifth in China, reflecting the increasing prevalence of obesity 4,5. MetS is characterized by dyslipidemia and glucose metabolism disorders, both of which are influenced by hepatic function. In fact, an association between MetS and non-alcoholic fatty liver disease (NAFLD), chronic hepatitis C (CHC) and HCC has previously been demonstrated 6,7. Additionally, NAFLD is considered as the hepatic manifestation of MetS 8. It is also now widely confirmed that chronic hepatitis C virus infection may increase the risk of insulin resistance and type 2 diabetes 9. MetS is als...

show abstract

Section: Discussionmentioning

confidence: 99%

Association between Hepatitis B Virus Infection and Metabolic Syndrome in Southwest China: A Cross-sectional Study

Yan

Liao

Han

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Apoliproteins family contains several sub-classes, including ApoA, ApoB, ApoC and so on. Previous study showed that plasma ApoA1, ApoB and ApoA5 levels are decreased in CHB patients [14, 19, 20]. It is indicated that HBV suppresses the synthesis and secretion of ApoA1 by inducing the hypermethylation of the ApoA1 promoter [21], inhibits the expression of ApoB via the suppression of microsomal triglyceride transfer protein [22] and blocks the levels of ApoA5 through its core gene [14].…”

Section: Discussionmentioning

confidence: 99%

Serum apolipoprotein C3 levels are negatively associated with hepatitis B virus DNA in HBeAg-negative chronic hepatitis B patients

Cui

et al. 2019

Lipids Health Dis

View full text Add to dashboard Cite

Background Hepatitis B virus (HBV) infection remains a global health issue associated with substantial morbidity and mortality. Serum apolipoprotein C3 (ApoC3) and apolipoprotein A5 (ApoA5) levels were decreased in chronic hepatitis B (CHB) patients, however the relationship between ApoC3 or ApoA5 and HBV DNA load remains elusive. Methods A total of 384 CHB patients including 194 HBsAg(+) HBeAg(−) and 190 HBsAg(+) HBeAg(+) and 154 healthy individuals were recruited in our study. Serum levels of alanine aminotransferase (ALT), aspartate transaminase (AST), total cholesterol (Chol), triglycerides (TG), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), high-density lipoproteins cholesterol (HDL-C), low-density lipoproteins cholesterol (LDL-C) and lipoprotein a (Lpa) were examined in an automatic biochemical analyzer. Apolipoprotein A5 (ApoA5) and apolipoprotein C3 (ApoC3) were detected via ELISA. Results Serum ApoA1, ApoB, ApoC3 and ApoA5 levels were reduced in CHB patients. In HBeAg(−) CHB patients, plasma ApoC3 levels were negatively associated with HBV DNA load (r = 0.219, P < 0.001). But no correlation between ApoA5 and HBV DNA load was observed in CHB patients. Conclusions These data showed that HBV infection inhibits lipid metabolism and ApoC3 is negatively associated with HBV DNA load in HBeAg (−) CHB patients. These findings provided new evidence about the link between ApoC3-related lipid metabolism and immune response.

show abstract

“…The relationship between CHB and MetS has been explored in ten studies, nine of which focused on Asian populations [4][5][6][7][8][9][10][11][12][13]. The pooled estimates of a recent meta-analysis of 13 observational studies revealed that CHB was associated with reduced risk of MetS in East-Asian populations, in adults under 45 years old, and in males [14].…”

Section: Introductionmentioning

confidence: 99%

“…The relationship between CHB and dyslipidemia remained largely ambiguous due to inconsistent associations of CHB and individual lipid biomarker. Seven studies reported significantly lower levels of TC among individuals with CHB as compared to those without CHB [7,9,12,[19][20][21][22]. However, inconsistent findings were reported for TG and HDL-C levels [2,4,5,7,20,23,24].…”

Section: Introductionmentioning

confidence: 99%

Association between chronic hepatitis B infection and metabolic syndrome

Zhao

Shah

Sambamoorthi

2018

J Diabetes Metab Disord

View full text Add to dashboard Cite

show abstract

Association between Metabolic Syndrome and Hepatitis B Virus Infection in the Roma Population in Eastern Slovakia: a Population-Based Study

Cited by 17 publications

References 24 publications

Association between Hepatitis B Virus Infection and Metabolic Syndrome in Southwest China: A Cross-sectional Study

Association between Hepatitis B Virus Infection and Metabolic Syndrome in Southwest China: A Cross-sectional Study

Serum apolipoprotein C3 levels are negatively associated with hepatitis B virus DNA in HBeAg-negative chronic hepatitis B patients

Association between chronic hepatitis B infection and metabolic syndrome

Contact Info

Product

Resources

About