Association between microRNA-196a2 rs11614913, microRNA-146a rs2910164, and microRNA-423 rs6505162 polymorphisms and esophageal cancer risk: A meta-analysis

Abstract

Many observational studies have found that microRNA-196a2 rs11614913, microRNA-146a rs2910164, and microRNA-423 rs6505162 are associated with esophageal cancer risk. However, the results were mixed and inconsistent among these studies. We conducted a meta-analysis to assess the relationship between the polymorphisms of three microRNAs and esophageal cancer susceptibility. We systematically searched the PubMed and EMBASE databases to screen relevant studies. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to compute the risk of esophageal cancer. Because of the differences in ethnicities, sources of controls, and genotyping methods, the meta-analysis was conducted using a random-effect model regardless of heterogeneity. To further explore potential heterogeneity, we performed subgroup and sensitivity analyses, and publication bias was also evaluated. A total of 6 case-control studies on microRNA-196a2 rs11614913, 4 studies on microRNA-146a rs2910164, and 4 studies on microRNA-423 rs6505162 were considered eligible in the meta-analysis. No statistical association was found between microRNA-196a2 rs11614913, microRNA-146a rs2910164, and microRNA-423 rs6505162 polymorphisms and esophageal cancer susceptibility in any genetic model. Subgroup and sensitivity analyses showed similar results. In summary, based on the currently limited proof, no association exists between microRNA-196a2 rs11614913, microRNA-146a rs2910164, and microRNA-423 rs6505162 polymorphism and esophageal cancer risk. However, the result should be cautiously interpreted because of the heterogeneity among studies. Large, high quality clinical trials are required to verify our findings.

Association of genetic variations in miR-146a rs2910164 and miR-149 rs11614913 with the development of classic Kaposi sarcoma

“…Similarly, Zhang et al (2015) performed a meta-analysis with six studies, and reported that no significant association was found between rs2910164 and rs11614913 polymorphisms and risk of gastric cancer. Another meta-analysis with six case-control studies also indicated that no correlation was found between miR-146a rs2910164 polymorphism and the risk of esophageal cancer (Ji et al, 2015). Our study, for the first time, showed a significant association between miR-146a polymorphism and risk of classic Kaposi sarcoma.…”

“…Furthermore, Yin et al (2016) reported that miRNA146a rs2910164 may influence genetic susceptibility to lung cancer in Chinese smokers. However, some studies were unable to find any association between miR-146a polymorphism and risk of cancers (Chen et al, 2015a;Ji et al, 2015;Zhang et al, 2015;Hashemi et al, 2016;Xia et al, 2016). For example, in a meta-analysis composed of 2766 patients with head and neck cancer and 6603 healthy controls, Chen et al (2015a) reported that miR-146a rs2910164 C>G polymorphism was not associated with this type of cancer.…”

Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta‐analysis and genome‐wide association studies

“…We performed statistical power analyses to determine the stability of the associations. In our meta‐analysis results, 13 variants were not significantly associated with EC or ESCC risk . The variants (Arg399Gln on XRCC1) with sample sizes >10 000 were also not significantly associated with EC; further investigations for this variant may not be fruitful.…”

Oxidative Stress and Antioxidant Therapy in Critically Ill Polytrauma Patients with Severe Head Injury

“…MicroRNAs are 19-23 nucleotide-containing biomolecules, representing a small fraction of the total mass of ribonucleic acid (RNA) [34], a number of which can be linked to a series of physiological dysfunctions. Thus, microRNAs extracted from biological samples can be used as a biomarker for diagnosis of physiological and biochemical imbalances, including cancer, neurodegenerative disorders, inflammation, infection with different pathogens, metabolism disorders, oxidative stress and poisoning [35,36].…”