Association between migraine and irritable bowel syndrome: a population‐based retrospective cohort study

Lau, Chi Ieong; Lin, Cheng‐Li; Chen, W. H.; Wang, Han-Cheng; Kao, Chia‐Hung

doi:10.1111/ene.12468

Cited by 54 publications

(56 citation statements)

References 41 publications

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“…A recent population-based retrospective cohort study in Taiwan found that the incidence of IBS was 1.95-fold higher in the migraine cohort than non-migraineurs. This was particularly evident in the cohort of migraineurs younger than 30 years old, who exhibited a 3.36-fold increased risk of IBS [69]. It is theorized that the underlying pathophysiology of IBS and migraine is a genetically established hypersensitive or hyperexcitable brain.…”

Section: Migraine and Gi Disordersmentioning

confidence: 98%

What the Gut Can Teach Us About Migraine

Hindiyeh

Aurora

2015

Curr Pain Headache Rep

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During gestation, cells of the brain and gut develop almost simultaneously into the central nervous system (CNS) and enteric nervous system (ENS), respectively. They remain connected via the vagal nerve lifelong. While it is well known that the brain sends signal to the gut, communication is in fact bidirectional. Just as the brain can modulate gut functioning, the gut, and likely what we ingest, can in fact influence our brain functioning. We will first review both gastrointestinal (GI) function and migraine pathophysiology and then discuss evidence linking the migraine brain to various GI disorders. Lastly, we discuss the effects of gut microbiota on brain functioning and speculate how the gut and particularly diet may affect migraine.

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Section: Migraine and Gi Disordersmentioning

confidence: 98%

What the Gut Can Teach Us About Migraine

Hindiyeh

Aurora

2015

Curr Pain Headache Rep

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“…Similar adjustments increase the incidence figures from 68 to 70 per 10 000 for asthma23 and from 30.1 to 35.4 per 10 000 person-years for migraine 24. The corresponding figures for the 12 general population samples that were comparison cohorts for a specific general medical disorder was 43.8 (range 3-86.7) (Table 2).…”

mentioning

confidence: 90%

“…27,33,34 Other functional gastrointestinal disorders, such as dyspepsia and GERD, together with pain and sleep disorders have been shown to be very closely associated with IBS and might share a common aetiological pathway. 24,29,34 These are diverse and might be directly or indirectly associated with the aetiology of IBS. 24,29,34 These are diverse and might be directly or indirectly associated with the aetiology of IBS.…”

Section: Breadth and Strength Of Risk Factorsmentioning

confidence: 99%

“…The data are too sparse to tabulate but there is some evidence of an exposure-response relationship between IBS onset and severity of gastroenteritis, 7,22,31 migraine,24 anxiety, 27 number of stressors 32 and frequency of healthcare use 27,33,34. The data are too sparse to tabulate but there is some evidence of an exposure-response relationship between IBS onset and severity of gastroenteritis, 7,22,31 migraine,24 anxiety, 27 number of stressors 32 and frequency of healthcare use 27,33,34.…”

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confidence: 99%

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Review article: the incidence and risk factors for irritable bowel syndrome in population‐based studies

Creed

2019

Aliment Pharmacol Ther

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Background:In the absence of prior gastrointestinal infection, the risk factors for irritable bowel syndrome (IBS) are not well established.Aim: To identify the incidence and risk factors for IBS in general population samples Methods: Narrative review of population-based studies. Electronic databases were searched using the keywords "incidence," "onset," "epidemiology," "population," "risk factors" with "irritable bowel syndrome" with subsequent hand searching. Inclusion criteria were: population-based, adults, prospective design (including retrospective case cohorts), clinical or research diagnosis of IBS and exclusion of individuals who had IBS prior to recruitment. Results:Of 1963 papers, 38 were included; all provided data on risk factors, 27 reported incidence. The median incidence of physician-diagnosed IBS in 19 general population cohorts was 38.5 per 10 000 person-years (interquartile range = 20-45.3).In 14 cohorts with specific medical disorders, median incidence was 92 per 10 000 person-years (IQR: 73.9-119). Apart from gastroenteritis, the most common risk factors were other medical disorders, female sex, age (both young and old), anxiety and depression, life events/stress, frequent healthcare use, pain and sleep disorders. The results were conflicting for alcohol consumption, smoking and BMI. Incidence rates were similar in different countries but risk factors differed.Conclusions: Incidence rates were generally lower than previous estimates reflecting physician-diagnosed IBS. The results highlight the importance of other medical and psychosocial problems in the onset of IBS in addition to prior gastrointestinal infections. Aetiological research could be enhanced by studying the underlying mechanisms relating to all of these risk factors.

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“…But the great majority of time is spent managing patients with primary headache such as Migraine. Headaches can be primary due to overactivity of pain-sensitive areas like nerves, blood vessels and muscles of head and neck or due to changes in chemical activity of brain in cases of Migraines and Secondary due to conditions that stimulate these pain-sensitive areas as in GERD (3,17,42) .…”

Section: Discussion and Conclusion:-mentioning

confidence: 99%

Case Study of Gastro-Oesophageal Reflux Disease (Gerd) v/ S Migraine: Do They Mingle or Is It a Myth.

MS¹

2017

IJAR

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Introduction: Over the years, there has been a dilemma regarding arriving at a diagnosis for headache pertaining to its variety of causes. One of the most common overlooked cause in the present day scenario for headache is GERD and Migraine. On day to day basis, we come across varied patient symptomatology which has indeed made us give a second thought to prescribe on management. Aim and Objective: To study if GERD and Migraine actually co-exist or they have a separate root cause for headache and also how change in lifestyle has an impact on health. Methodology: A study of random sample of 450 patients was conducted based on clinical evaluation for diagnosis and conservative management for the same was advised emphasising particularly on lifestyle modification. Results:The results drawn were compared by tabulating them into 3 groups with the two conditions taken as a separate entity and third when the two being mingled to conclude if interlink exists between the two conditions or purely is it a myth. Conclusion: Intermingling of GERD and Migraine was noted predominantly in our study rather than their separate existence.

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Association between migraine and irritable bowel syndrome: a population‐based retrospective cohort study

Abstract: The current population-based study demonstrated that migraine is associated with an increased risk of IBS after adjusting for comorbidities, particularly in the young population.

Cited by 54 publications

References 41 publications

What the Gut Can Teach Us About Migraine

What the Gut Can Teach Us About Migraine

Review article: the incidence and risk factors for irritable bowel syndrome in population‐based studies

Case Study of Gastro-Oesophageal Reflux Disease (Gerd) v/ S Migraine: Do They Mingle or Is It a Myth.

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