Association between migration and severe maternal outcomes in high-income countries: Systematic review and meta-analysis

Abstract

Background Literature focusing on migration and maternal health inequalities is inconclusive, possibly because of the heterogeneous definitions and settings studied. We aimed to synthesize the literature comparing the risks of severe maternal outcomes in high-income countries between migrant and native-born women, overall and by host country and region of birth. Methods and findings Systematic literature review and meta-analysis using the Medline/PubMed, Embase, and Cochrane Library databases for the period from January 1, 1990 to April 18, 2023. We included observational studies comparing the risk of maternal mortality or all-cause or cause-specific severe maternal morbidity in high-income countries between migrant women, defined by birth outside the host country, and native-born women; used the Newcastle–Ottawa scale tool to assess risk of bias; and performed random-effects meta-analyses. Subgroup analyses were planned by host country and region of birth. The initial 2,290 unique references produced 35 studies published as 39 reports covering Europe, Australia, the United States of America, and Canada. In Europe, migrant women had a higher risk of maternal mortality than native-born women (pooled risk ratio [RR], 1.34; 95% confidence interval [CI], 1.14, 1.58; p < 0.001), but not in the USA or Australia. Some subgroups of migrant women, including those born in sub-Saharan Africa (pooled RR, 2.91; 95% CI, 2.03, 4.15; p < 0.001), Latin America and the Caribbean (pooled RR, 2.77; 95% CI, 1.43, 5.35; p = 0.002), and Asia (pooled RR, 1.57, 95% CI, 1.09, 2.26; p = 0.01) were at higher risk of maternal mortality than native-born women, but not those born in Europe or in the Middle East and North Africa. Although they were studied less often and with heterogeneous definitions of outcomes, patterns for all-cause severe maternal morbidity and maternal intensive care unit admission were similar. We were unable to take into account other social factors that might interact with migrant status to determine maternal health because many of these data were unavailable. Conclusions In this systematic review of the existing literature applying a single definition of “migrant” women, we found that the differential risk of severe maternal outcomes in migrant versus native-born women in high-income countries varied by host country and region of origin. These data highlight the need to further explore the mechanisms underlying these inequities. Trial Registration PROSPERO CRD42021224193.

Global health systems strengthening: FIGO's strategic view on reducing maternal and newborn mortality worldwide

“…Despite significant progress in reducing maternal deaths globally and the rise of relatively affordable and effective life‐saving technologies, inequities in maternal and perinatal health persist and, in some cases, even widen within and between countries and subpopulations. Although the rise in maternal deaths affects mainly low‐income countries (LICs), where the burden of 94% of worldwide maternal fatalities occurs, evidence from high‐income countries (HICs) reveals that marginalized, racial, and immigrant populations are also at markedly elevated risk 2 …”

Women’s country of birth and failure to catch up an overdue cervical cancer cytological screening participation during pregnancy in France, an observational study based on survey sources

“…Although the performance of this screening has not been evaluated in pregnant women, the French Health Authority has recommended since 2007 Pap tests for all woman at the beginning of pregnancy if their last test took place more than three years earlier [ 30 ]. Maternal health inequalities according to maternal place of birth have been described in high-income countries, specifically in France [ 31 , 32 ]. It is important to know if these inequalities also affect cervical cancer screening during pregnancy.…”