Association between multivitamin supplementation and mortality among patients with Ebola virus disease: An international multisite cohort study

Yam, Derrick; Aluisio, Adam R.; Perera, Shiromi M.; Peters, Jillian; Cho, Daniel K.; Kennedy, Stephen B.; Massaquoi, Moses; Sahr, Foday; Smit, Michael; Locks, Lindsey M.; Liu, Tao; Levine, Adam C.

doi:10.1016/j.afjem.2019.11.001

Cited by 8 publications

(5 citation statements)

References 43 publications

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“…The relationship between dexamethasone and thiamine caused more inhibition of IL-6 production compared to dexamethasoneinduced. Multivitamin supplementation within 48 h of hospital admission, including thiamine, riboflavin, and niacin was associated with lower overall mortality in patients with Ebola Virus Disease (158).…”

Section: B Vitaminsmentioning

confidence: 92%

Clinical Impact Potential of Supplemental Nutrients as Adjuncts of Therapy in High-Risk COVID-19 for Obese Patients

Şahin

Orhan

Uckun³

et al. 2020

Front. Nutr.

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The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 caused a major global pandemic and continues to be an unresolved global health crisis. The supportive care interventions for reducing the severity of symptoms along with participation in clinical trials of investigational treatments are the mainstay of COVID-19 management because there is no effective standard therapy for COVID-19. The comorbidity of COVID-19 rises in obese patients. Micronutrients may boost the host immunity against viral infections, including COVID-19. In this review, we discuss the clinical impact potential of supplemental nutrients as adjuncts of therapy in high-risk COVID-19 for obese patients.

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Section: B Vitaminsmentioning

confidence: 92%

Clinical Impact Potential of Supplemental Nutrients as Adjuncts of Therapy in High-Risk COVID-19 for Obese Patients

Şahin

Orhan

Uckun³

et al. 2020

Front. Nutr.

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“…Variable selection for inclusion in the multivariable modeling were based on identified evidence of difference (p < 0.05) in the bivariate analyses as well as on previous literature demonstrating associations with mortality in EVD. The variables included in the multivariable models, based on past literature, included: multivitamin (MVI) treatment [ 44 ], Cefixime treatment [ 45 ], clinical signs and symptoms of bleeding, diarrhea, dyspnea, and dysphagia [ 7 ], initial CT value and age [ 43 ]. Age was modeled with a cubic spline due to the previously documented quadratic relationship between age and mortality in EVD [ 43 ].…”

Section: Methodsmentioning

confidence: 99%

Association between oral antimalarial medication administration and mortality among patients with Ebola virus disease: a multisite cohort study

et al. 2022

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Background Empiric antimalarial treatment is a component of protocol-based management of Ebola virus disease (EVD), yet this approach has limited clinical evidence for patient-centered benefits. Methods This retrospective cohort study evaluated the association between antimalarial treatment and mortality among patients with confirmed EVD. The data was collected from five International Medical Corps operated Ebola Treatment Units (ETUs) in Sierra Leone and Liberia from 2014 through 2015. The standardized protocol used for patient care included empiric oral treatment with combination artemether and lumefantrine, twice daily for three days; however, only a subset of patients received treatment due to resource variability. The outcome of interest was mortality, comparing patients treated with oral antimalarials within 48-h of admission to those not treated. Analysis was conducted with logistic regression to generate adjusted odds ratios (aORs). Multivariable analyses controlled for ETU country, malaria rapid diagnostic test result, age, EVD cycle threshold value, symptoms of bleeding, diarrhea, dysphagia and dyspnea, and additional standard clinical treatments. Results Among the 424 cases analyzed, 376 (88.7%) received early oral antimalarials. Across all cases, mortality occurred in 57.5% (244). In comparing unadjusted mortality prevalence, early antimalarial treated cases yielded 55.1% mortality versus 77.1% mortality for those untreated (p = 0.005). Multivariable analysis demonstrated evidence of reduced aOR for mortality with early oral antimalarial treatment versus non-treatment (aOR = 0.34, 95% Confidence Interval: 0.12, 0.92, p = 0.039). Conclusion Early oral antimalarial treatment in an EVD outbreak was associated with reduced mortality. Further study is warranted to investigate this association between early oral antimalarial treatment and mortality in EVD patients.

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“…Because of this, sales of these products have increased but suspicions have arisen regarding their actual efficacy against H1N1 in humans [ 13 , 14 ]. In trials of patients with Ebola virus infection, multivitamin therapy was associated with lower mortality rates [ 15 ]. In view of these results following past pandemics, it is prudent to consider the possibility that the current COVID-19 virus may have affected today’s population in a similar manner.…”

Section: Predictions From Past Pandemicsmentioning

confidence: 99%

The Impact of Nutrition on the COVID-19 Pandemic and the Impact of the COVID-19 Pandemic on Nutrition

Rodriguez-Leyva

Pierce

2021

Nutrients

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The coronavirus disease 2019 (COVID-19) pandemic has had significant morbidity, mortality, social and financial implications for the global population. Despite this knowledge, we still know very little about how COVID-19 infection affects quality of life resulting from changes in nutritional behaviour and, conversely, how nutrition could modulate the epidemiology of COVID-19. In addition, the social isolation most have experienced due to the regulations imposed by governments during the COVID-19 pandemic may have also had effects on our nutritional behaviour. It is possible that nutritional interventions may have effects on the incidence of COVID-19 infection and mortality rates. The purpose of this review is to evaluate the current status of research on the topic of nutrition as it relates to the COVID-19 pandemic.

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Association between multivitamin supplementation and mortality among patients with Ebola virus disease: An international multisite cohort study

Cited by 8 publications

References 43 publications

Clinical Impact Potential of Supplemental Nutrients as Adjuncts of Therapy in High-Risk COVID-19 for Obese Patients

Clinical Impact Potential of Supplemental Nutrients as Adjuncts of Therapy in High-Risk COVID-19 for Obese Patients

Association between oral antimalarial medication administration and mortality among patients with Ebola virus disease: a multisite cohort study

The Impact of Nutrition on the COVID-19 Pandemic and the Impact of the COVID-19 Pandemic on Nutrition

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