Association between neurologic and cognitive dysfunction signs in a sample of aging dogs

Golini, Lorenzo; Colangeli, R.; Tranquillo, V.; Mariscoli, Massimo

doi:10.1016/j.jveb.2008.09.033

Cited by 23 publications

(21 citation statements)

References 23 publications

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“…As there is a huge variation in how long dogs of different breeds live [24] , the point when aging begins varies with the breed, size, and weight of the dog [25] . Different authors have made different suggestions in this regard (Golini et al [26] have reported 7 years, while Neilson et al [27] have indicated 11 years). A majority of aging studies in laboratory beagles have compared dogs aged over 7 years to younger dogs (age <7 years) in order to investigate cognitive decline associated with aging.…”

Section: Normal Agingmentioning

confidence: 99%

Cognitive Aging in Dogs

Chapagain¹,

Range²,

Huber³

et al. 2017

Gerontology

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vere cognitive dysfunction. We suggest that multi-targeted approaches that combine owner-evaluated questionnaires with neuropsychological tests can be most effective in screening cognitively affected dogs from normally aging dogs. Regarding preventive measures, we conclude that combinations of dietary intervention and behavioral enrichment may be more beneficial than single-pathway manipulations in delaying cognitive aging or retaining various cognitive functions during aging.

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Section: Normal Agingmentioning

confidence: 99%

Cognitive Aging in Dogs

Chapagain¹,

Range²,

Huber³

et al. 2017

Gerontology

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“…To facilitate the detection of CCD, veterinarians can use a screening questionnaire that includes a list of possible signs. Several questionnaires are available and based on the scores the stage of dog’s cognitive decline can be identified (Colle et al, 2000; Neilson et al, 2001; Osella et al, 2007; Azkona et al, 2009; Golini et al, 2009; Salvin et al, 2011; Landsberg et al, 2012; Rosado et al, 2012; Fast et al, 2013b; Madari et al, 2015). Madari et al (2015) have proposed criteria for discrimination of three stages of the disease, these are mild cognitive impairment, moderate cognitive impairment, and severe cognitive impairment.…”

Section: Diagnosis Of Ccdmentioning

confidence: 99%

Canine Cognitive Dysfunction and Alzheimer’s Disease – Two Facets of the Same Disease?

Mihevc

Majdič

2019

Front. Neurosci.

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Neurodegenerative diseases present a major and increasing burden in the societies worldwide. With aging populations, the prevalence of neurodegenerative diseases is increasing, yet there are no effective cures and very few treatment options are available. Alzheimer's disease is one of the most prevalent neurodegenerative conditions and although the pathology is well studied, the pathogenesis of this debilitating illness is still poorly understood. This is, among other reasons, also due to the lack of good animal models as laboratory rodents do not develop spontaneous neurodegenerative diseases and human Alzheimer's disease is only partially mimicked by transgenic rodent models. On the other hand, older dogs commonly develop canine cognitive dysfunction, a disease that is similar to Alzheimer's disease in many aspects. Dogs show cognitive deficits that could be paralleled to human symptoms such as disorientation, memory loss, changes in behavior, and in their brains, beta amyloid plaques are commonly detected both in extracellular space as senile plaques and around the blood vessels. Dogs could be therefore potentially a very good model for studying pathological process and novel treatment options for Alzheimer's disease. In the present article, we will review the current knowledge about the pathogenesis of canine cognitive dysfunction, its similarities and dissimilarities with Alzheimer's disease, and developments of novel treatments for these two diseases with a focus on canine cognitive dysfunction.

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“…Most scales utilize separate subscales (domains), such as spatial orientation or house soiling as a basis of their scoring system, but the lack of item stability within categories across questionnaires is problematic. For instance, the item “Decreased recognition of/Does not recognise familiar people” has been classified as a sign of impairment in three different domains depending on the study: “Disorientation” [14], “Social interactions” [8], and “Learning and memory: work, tasks, commands” [15]. To date no report of the internal consistency of these domain specific scales has been published.…”

Section: Introductionmentioning

confidence: 99%

Owner reported sensory impairments affect behavioural signs associated with cognitive decline in dogs

Szabó¹,

Miklósi²,

Kubinyi³

2018

Behavioural Processes

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To describe the extent of age-related cognitive decline in dogs, information regarding the baseline occurrence of associated behaviours in the general population is necessary. With a seven-item, data driven Age-Related Changes scale, we evaluated the relationship between sensory functions, training, sex, and the occurrence of behavioural signs associated with cognitive decline across the whole adult lifespan. The twofold difference in lifespan between small and large dogs presents challenges for ageing studies, with no widely accepted method to control for body size as it relates to chronological age and longevity, when comparing behavioural signs of cognitive decline. To address this issue, we utilized relative age, calculated using the estimated expected lifespan of the individuals in our questionnaire study. Signs of cognitive decline were already detectable in' Mature' dogs (at 50-75% of the expected lifespan). Visual, auditory and olfactory impairments all resulted in significantly higher scores on the Age-Related Changes scale. Participating in dog training activities was revealed to be protective against behavioural signs of cognitive decline in aged dogs as perceived by the owners. These results revealed possible beneficial effects of training on cognitive ageing and emphasize the importance of routinely screening the sensory capacities of ageing dogs.

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Association between neurologic and cognitive dysfunction signs in a sample of aging dogs

Cited by 23 publications

References 23 publications

Cognitive Aging in Dogs

Cognitive Aging in Dogs

Canine Cognitive Dysfunction and Alzheimer’s Disease – Two Facets of the Same Disease?

Owner reported sensory impairments affect behavioural signs associated with cognitive decline in dogs

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