Association Between Nitrite and Nitrate Intake and Risk of Gastric Cancer: A Systematic Review and Meta-Analysis

Zhang, Feixiong; Ming, Yu; Ruan, Jigang; Meng, Shuping; Dong, Jia; Yin, Huabin; Huang, Ying; Chen, Fu‐Rong; Wang, Zhen-Chuan; Lai, Yafang

doi:10.12659/msm.914621

Cited by 50 publications

(35 citation statements)

References 48 publications

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“…As a physical treatment, it can modify the chemical and physical properties of biological systems at varying levels depending on the processing conditions (e.g. frequency, intensity, and duration) and the herb's structure and composition [7] . The technology is a green technology that offers opportunities to create new functional products or extract more powerful functional bioactive compounds from herbs.…”

Section: Introductionmentioning

confidence: 99%

Recent innovations of ultrasound green technology in herbal phytochemistry: A review

Gouda

Bekhit

Tang

et al. 2021

Ultrasonics Sonochemistry

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Highlights Ultrasound enhances the phenolic compounds in extracted herbal oils by 44%. US (25–50 kHz) increases the yields of polyphenols, carotenoids, and flavonoids. Radicals generated by US have positive and negative effects on enzymes. US improves the efficiency of herbal extracts in Nanotechnology applications. Acoustic-based biosensors could be used for chemical imaging of herbal tissues.

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Section: Introductionmentioning

confidence: 99%

Recent innovations of ultrasound green technology in herbal phytochemistry: A review

Gouda

Bekhit

Tang

et al. 2021

Ultrasonics Sonochemistry

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“…Unavailable for workers of the study cohort information on such considerable risk factors for StoCa, as H. pylori infection and nitrite and nitrate intakes with drinking water and food [50], potentially might confound the results obtained in the present analysis. Additionally, a relatively low number of StoCa cases did not allow for a more detailed analysis of the modification effect of quantitative smoking parameters on the StoCa incidence risk.…”

Section: Plos Onementioning

confidence: 92%

Risk of stomach cancer incidence in a cohort of Mayak PA workers occupationally exposed to ionizing radiation

2020

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Stomach cancer is a widespread health condition associated with environmental and genetic factors. Contribution of ionizing radiation to stomach cancer etiology is not sufficiently studied. This study was aimed to assess an association of the stomach cancer incidence risk with doses from occupational radiation exposure in a cohort of workers hired at main Mayak production association facilities in 1948-1982 taking into account non-radiation factors including digestive disorders. The study cohort comprised 22,377 individuals and by 31.12.2013 343 stomach cancer diagnoses had been reported among the cohort members. Occupational stomach absorbed doses were provided by the Mayak Worker Dosimetry System-2008 (MWDS-2008) for external gamma ray exposure and by the Mayak Worker Dosimetry System-2013 (MWDS-2013) for internal exposure to plutonium. Excess relative risks (ERR) per Gy for stomach cancer were estimated using the Poisson's regression. Analyses were run using the AMFIT module of the EPICURE software. The stomach cancer incidence risk in the study cohort was found to be significantly associated with the stomach absorbed dose of gamma rays: ERR/Gy = 0.19 (95% CI: 0.01, 0.44) with a 0 year lag, and ERR/Gy = 0.20 (95% CI: 0.01, 0.45) with a 5 year lag. To estimate the baseline risk, sex, attained age, smoking status and alcohol consumption, chronic diseases (peptic ulcer, gastritis and duodenitis) were taken into account. No modifications of the radiogenic risk by non-radiation factors were found in the study worker cohort. No association of the stomach cancer incidence risk with internal exposure to incorporated plutonium was observed.

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“…A recent meta-analysis showed an increased risk gastric cancer with oral nitrite but reduced risk with oral nitrate. 85 Dietary nitrate is known to modify the oral and gastric biome (Table 7).…”

Section: Dietary Inorganic Nitratementioning

confidence: 99%

Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections

et al. 2021

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Although the antimicrobial potential of nitric oxide (NO) is widely published, it is little used clinically. NO is a key signalling molecule modulating vascular, neuronal, inflammatory and immune responses. Endogenous antimicrobial activity is largely mediated by high local NO concentrations produced by cellular inducible nitric oxide synthase, and by derivative reactive nitrogen oxide species including peroxynitrite and S-nitrosothiols. NO may be taken as dietary substrate (inorganic nitrate, L-arginine), and therapeutically as gaseous NO, and transdermal, sublingual, oral, intranasal and intravenous nitrite or nitrate. Numerous preclinical studies have demonstrated that NO has generic static and cidal activities against viruses (including β-coronaviruses such as SARS-CoV-2), bacteria, protozoa and fungi/yeasts in vitro. Therapeutic effects have been seen in animal models in vivo, and phase II trials have demonstrated that NO donors can reduce microbial infection. Nevertheless, excess NO, as occurs in septic shock, is associated with increased morbidity and mortality. In view of the dose-dependent positive and negative effects of NO, safety and efficacy trials of NO and its donors are needed for assessing their role in the prevention and treatment of infections. Trials should test dietary inorganic nitrate for pre- or post-exposure prophylaxis and gaseous NO or oral, topical or intravenous nitrite and nitrate for treatment of mild-to-severe infections, including due to SARS-CoV-2 (COVID-19). This review summarises the evidence base from in vitro, in vivo and early phase clinical studies of NO activity in viral, bacterial, protozoal and fungal infections.

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Association Between Nitrite and Nitrate Intake and Risk of Gastric Cancer: A Systematic Review and Meta-Analysis

Cited by 50 publications

References 48 publications

Recent innovations of ultrasound green technology in herbal phytochemistry: A review

Recent innovations of ultrasound green technology in herbal phytochemistry: A review

Risk of stomach cancer incidence in a cohort of Mayak PA workers occupationally exposed to ionizing radiation

Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections

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