Association between Nutritional Status and Severity of Dengue Infection in Children in El Salvador

Marón, Gabriela; Clara, Alexey; Diddle, J. Wesley; Pleités, Ernesto; Miller, Laura L.; MacDonald, Glen C.; Adderson, Elisabeth E.

doi:10.4269/ajtmh.2010.09-0365

Cited by 39 publications

(48 citation statements)

References 25 publications

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“…A study in El Salvador also found no significant relationship between nutritional status and DHF severity. 16 Our patients got shock for the first time on days 4 and 5 fever, similar to previous studies. 2,6 The pathomechanism of DHF involves leukocyte migration on day 5, and increasing numbers of immature neutrophils.…”

Section: Discussionsupporting

confidence: 90%

Association between interleukin-8 and severity of dengue shock syndrome in children

Tatura

Daud

Yusuf

et al. 2016

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Section: Discussionsupporting

confidence: 90%

Association between interleukin-8 and severity of dengue shock syndrome in children

Tatura

Daud

Yusuf

et al. 2016

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“…[14][15][16][17][18][19][20] Earlier studies have, contradictorily, found that malnourished children are less likely to develop DHF/DSS compared with well-nourished children, but recent studies have not supported this finding. 21 Overall, the association between nutritional status and risk of DENV infection remains unclear. There is no evidence to suggest that nutritional status could interrupt transmission or alter susceptibility to infection after the bite of a dengue-infected mosquito; however, host nutritional status or micronutrient supplementation as adjuvant therapy could lower the probability of progressing from DENV infection to overt/severe forms of disease or reduce disease severity in patients.…”

Section: Introductionmentioning

confidence: 99%

Micronutrients and Dengue

Ahmed

Finkelstein

Stewart

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Dengue virus infection is the most widespread mosquito-borne viral infection in humans and has emerged as a serious global health challenge. In the absence of effective treatment and vaccine, host factors including nutritional status, which may alter disease progression, need investigation. The interplay between nutrition and other infections is well-established, and modulation of nutritional status often presents a simple low-cost method of interrupting transmission, reducing susceptibility, and/or ameliorating disease severity. This review examines the evidence on the role of micronutrients in dengue virus infection. We found critical issues and often inconsistent results across studies; this finding along with the lack of sufficient literature in this field have limited our ability to make any recommendations. However, vitamins D and E have shown promise in small supplementation trials. In summary, the role of micronutrients in dengue virus infection is an exciting research area and needs to be examined in well-designed studies with larger samples.

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“…17 Penelitian kami menunjukkan hasil yang mendukung teori tersebut. Sedangkan Maron dkk, 18 Malavige dkk, 12 Dewi dkk, 9 dan Tantracheewatron (2007) 19 tidak mendapatkan perbedaan bermakna antara status gizi baik dan gizi kurang.…”

Section: Diskusiunclassified

Faktor Prognosis Terjadinya Syok pada Demam Berdarah Dengue

Raihan

Hadinegoro

Tumbelaka

2016

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Latar belakang. Infeksi virus dengue hingga saat ini masih menjadi masalah kesehatan di Indonesia.Mengingat manifestasi klinis yang sangat bervariasi, diagnosis klinis awal demam berdarah dengue (DBD)sering sulit ditegakkan, apalagi untuk memprediksi apakah seorang pasien akan menjadi syok atau syokberulang. Penilaian akurat terhadap risiko syok merupakan kunci penting menuju tatalaksana yang adekuat,mencegah syok, dan perdarahan.Tujuan. Mencari parameter klinis dan laboratoriss sebagai faktor resiko terjadinya syok pada pasienDBD.Metode. Penelitian retrospektif dengan menggunakan data rekam medik pasien DBD yang memenuhikriteria WHO 1997 dan dikonfirmasi dengan pemeriksaan serologi di Bagian Ilmu Kesehatan Anak RSUPDr Cipto Mangunkusumo Jakarta dari Januari 2007-Desember 2009. Variabel independen adalah lamademam, perdarahan, hepatomegali, hemokonsentrasi, leukosit, trombosit. Faktor prognosis syok merupakanvariabel dependen. Analisis dengan menggunakan analisis regresi logistikHasil. Dari 276 pasien yang memenuhi kriteria penelitian, 139 di antaranya (50,3%) perempuan dan 137(49,6%) laki-laki dengan usia 5-10 tahun sebagai kelompok terbanyak. Lebih separuh pasien (69,2%)mempunyai gizi baik. Syok terjadi pada 103 (37,3%) pasien terutama pada hari keempat sakit (81,6%).Hepatomegali ditemukan pada 49,6% kasus, perdarahan saluran cerna 14,9%, hemokonsentrasi 81,2%,kadar hematokrit 􀁴42% 54,3%. leukosit <5.000/mm3 76,8% dan jumlah trombosit 􀁴50.000-100.000/mm367,4%. Hasil analisis regresi logistik menunjukkan hepatomegali dan perdarahan saluran cerna adalah faktorprognosis yang paling berperan terhadap terjadinya syok dengan AOR berturut-turut 13,8 dan 8,4.Kesimpulan. Karakteristik klinis yaitu hepatomegali dan perdarahan saluran cerna merupakan faktorprognosis terjadinya syok pada DBD.

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Association between Nutritional Status and Severity of Dengue Infection in Children in El Salvador

Cited by 39 publications

References 25 publications

Association between interleukin-8 and severity of dengue shock syndrome in children

Association between interleukin-8 and severity of dengue shock syndrome in children

Micronutrients and Dengue

Faktor Prognosis Terjadinya Syok pada Demam Berdarah Dengue

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