Association between occult hepatitis B infection and the risk of hepatocellular carcinoma: a meta‐analysis

Shi, Yu; Wu, Y.; Wu, Wei; Zhang, Wan Jun; Yang, Jun; Chen, Zhi

doi:10.1111/j.1478-3231.2011.02481.x

Cited by 146 publications

(118 citation statements)

References 33 publications

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“…In contrast, all HBV DNA-positive cases in the HCV group were positive for anti-HBc, and more than half were positive for anti-HBs. This result is in accordance with the fi nding that OBI is more prevalent in seropositive patients who are positive for anti-HBc and/or anti-HBs (23) (29) (37) (42) (43) . The occurrence of occult infection despite the presence of neutralizing an ti-HBs can result from mutations affecting the S region of the HBV genome (39) .…”

Section: Discussionsupporting

confidence: 80%

Occult HBV infection status among chronic hepatitis C and hemodialysis patients in Northeastern Egypt: regional and national overview

Mandour

Nemr

Shehata

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Introduction:Occult hepatitis B infection (OBI) is considered to be one of the major risks for patients suffering from end-stage renal disease (ESRD) on regular hemodialysis (HD) and patients with chronic hepatitis C virus (HCV) infection. This study compared the prevalence of OBI among these two high-risk groups in the Suez Canal region, Northeastern Egypt, to obtain a better national overview of the magnitude of OBI in this region. Methods: Serum samples were collected from 165 HD patients and 210 chronic HCV-infected patients. Anti-HCV antibody, hepatitis B surface antigen (HBsAg), total hepatitis B core (anti-HBc) antibody, and hepatitis B surface antibody (anti-HBs) were detected by enzyme-linked immunosorbent assay (ELISA). HCV RNA was detected using a quantitative real-time RT-PCR assay, and HBV was detected using a nested PCR. Results: All patients were negative for HBsAg. A total of 49.1% and 25.2% of the patients in the HD and HCV groups, respectively, were anti-HBc-positive. In addition, more anti-HBs-positive patients were detected in the HD group compared to the HCV group (52.1% and 11.4%, respectively). Three cases were positive for HBV DNA in the HD group, while eighteen positive cases were detected in the HCV group. Both study groups showed signifi cant differences in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level as well as anti-HBc, anti-HBs and HBV-DNA positivity. Conclusions: OBI was more prevalent among chronic HCV patients than HD patients in the Suez Canal region, Egypt, with rates of 8.5% and 1.8%, respectively. However, more precise assessment of this infection requires regular patient follow-up using HBV DNA detection methods.

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Section: Discussionsupporting

confidence: 80%

Occult HBV infection status among chronic hepatitis C and hemodialysis patients in Northeastern Egypt: regional and national overview

Mandour

Nemr

Shehata

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…Many studies confirm a relatively high frequency of occult hepatitis B viral infection in hemodialysed patients [2] [19] Hepatocellular carcinoma (HCC) [20] No case of HCC was noted in our study on condition of the anatomo-pathologic test which was not carried out in our patients. The occult hepatitis B viral infection prevalence varies from 10% -60% and even more in case of HCC with unknown aetiology [1].…”

Section: Occult Hepatitis B Viral Infection In Hemodialysed Patientsmentioning

confidence: 75%

Hepatitis B Surface Antigen Should Not Be the Only Sought Marker to Distinguish Blood Donors towards Hepatitis B Virus Infection in High Prevalence Area

Somda¹,

Sermé²,

Coulibaly³

et al. 2016

OJGas

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Since its discovery by Blumberg in 1965, the hepatitis B surface antigen (HBsAg) is used as the fingerprint of hepatitis B infection. Occult hepatitis B infection (OBI) is defined by a viral replication (DNA detectable) in the absence of HBsAg. Burkina Faso is a high endemic area where the prevalence is higher than 14%. At the National Center for Blood Transfusion (NCBT) of Ouagadougou, HBsAg is the only sought marker used to distinguish donors towards Hepatitis B Virus (HBV). Acceptation of blood donation is based specifically on the absence of HBsAg, which exposes to the risk of HBV transmission during transfusion. The goal of this study is to evaluate this risk by determining the prevalence of OBI in blood donors. Patients and Methods: It was a five-month prospective study on blood donations collected from January to May 2016. The HBc antibody has been sought in the serums of negative HBsAg donors. The measure of B DNA by Real Time PCR (polymerase chain reaction) and that of antibodies anti-HBs have been proposed to anti-HBc positive donors. Abdominal ultrasound, the transaminases, prothrombin level, alphafeto-proteins, hepatic fibrosis have been proposed to donors who were detectable for the DNA. Sociodemographic parameters have been collected. The test costs were borne by donors who were recalled by phone to adhere to the study. Results: Among 1980 negative donors HBsAg, 872 (44%) were positive for anti-HBc. 160 on 872 donors were received for consultation, among which 76 (76/160) were able to realise DNA which was detectable in 25 donors on 76, thus a prevalence of 32.8%. The mean value of DNA was 953 IU/ml. Physical examination and hepatic ultrasounds were normal except a case where hepatic steatosis was found. The biologic standard hepatic results were in normal range. None of the patient was able to realise hepatic fibrosis evaluation. A case of co-infection HIV/OBI was noted. Conclusion: This study shows that in BurHow to cite this paper: Somda, K.S., Sermé, A.K., Coulibaly, A., Cissé, K., Sawadogo, A., Sombié, A.R. and Bougouma, A. 363kina, almost half of blood bags transfused are anti-HBc positive and around one third (32.8%) probably have HBV DNA. This poses a potential risk of contamination for non-immunized recipient. It is thus important that, in addition to HBsAg, AntiHBc should be systematically sought in order to minimize the risk.

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“…Th ese authors found that 2.07% of blood donors had Anti-HBc total alone 25 . Shi et al suggested that occult HBV infection was associated with an increased risk of hepatocellular carcinoma 26 .…”

Section: Confl Ict Of Interest Disclosurementioning

confidence: 99%

Seroprevalence of hepatitis B and hepatitis C: A community based study conducted in İzmir, Turkey

Köse¹,

Mandıracıoğlu²,

Çavdar³

et al. 2014

Kafkas J Med Sci

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Association between occult hepatitis B infection and the risk of hepatocellular carcinoma: a meta‐analysis

Cited by 146 publications

References 33 publications

Occult HBV infection status among chronic hepatitis C and hemodialysis patients in Northeastern Egypt: regional and national overview

Occult HBV infection status among chronic hepatitis C and hemodialysis patients in Northeastern Egypt: regional and national overview

Hepatitis B Surface Antigen Should Not Be the Only Sought Marker to Distinguish Blood Donors towards Hepatitis B Virus Infection in High Prevalence Area

Seroprevalence of hepatitis B and hepatitis C: A community based study conducted in İzmir, Turkey

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