Association between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes mellitus

Abstract

Purpose: To investigate the association between ocular biometrical parameters and diabetic retinopathy (DR) in ocular treatment naive patients with diabetes. Methods: This cross-sectional study recruited type 2 diabetes mellitus patients with no history of ocular treatment in Guangzhou, China. The ocular biometrical parameters were obtained by Lenstar, including corneal diameter, central corneal thickness (CCT), corneal curvature (CC), anterior chamber depth (ACD), lens thickness (LT), and axial length (AL). The lens power and axial length-to-cornea radius ratio (AL/CR ratio) were calculated. Spherical equivalent (SE) was determined by auto-refraction after pupil dilation. Multivariate logistic regression analyses were performed to explore the associations of ocular biometry with any DR and vision threatening DR (VTDR).

Progressive Peripapillary Choroid Thinning and Retinal Neurodegeneration in Patients With Diabetes

“…This may partly explain why patients with DM with high myopia have a lower risk of developing DR, as the choroidal blood flow of highly myopic eyes is much lower than that of emmetropic eyes. 17,29 Our results highlight the potential value of longitudinal changes in OCT ocular parameters on monitoring and early prediction of DR onset. Currently, the monitoring and evaluation of DR onset are based on ocular and systemic risk factors that were identified through crosssectional studies and fluctuate with various confounding factors.…”

“…According to previous findings, we performed four multivariable models: model 1 adjusted for age, sex, AL, model 2 further adjusted for glycosy-lated hemoglobin level, systolic blood pressure, diastolic blood pressure, total cholesterol, best-corrected visual acuity, model 3 further adjusted for DM duration, and model 4 additionally adjusted for average values of systolic blood pressure, diastolic blood pressure, and total cholesterol during the 3-year period. 4,[12][13][14][15][16][17] A P value of ,0.05 was considered statistically significant. All analyses were performed using Stata Version 17.0 (Stata Corporation, College Station, TX).…”

Effect of diabetes mellitus on quantitative corneal anatomy – A systemic review

“…Storr-Paulsen et al 3 Schultz et al 37 Busted et al 15 Keoleian et al 38 Olsen et al 16 Inoue et al 39 Larsson et al 17 Sudhir et al 40 McNamara et al 14 Ziadi et al 41 Roszkowska et al 18 Sonmez et al 42 Rosenberg et al 19 Wiemer et al 43 Lee et al 20 Beato et al 47 Su et al 21 Wang et al 54 Oriowo et al 22 Xiao et al 55 Modis et al 23 Wang et al 57 Ozdamar et al 24 Calvo-Maroto et al 25 Briggs et al 26 Sanchis-Gimeno et al 27 Altay et al 30 Kumar et al 44 Jeziorny et al 45 Luo et al 46 Ramm et al 48 Çolak et al 49 Hanyuda et al 50 Taşlı et al 51 Srećković et al 52 Suraida et al 53 Deák et al 56 Kim and Kim 58 CCT, central corneal thickness.…”

“…McNamara et al 14 Storr-Paulsen et al 3 Su et al 21 Olsen et al 16 Modis et al 23 Roszkowska et al 18 Luo et al 46 Rosenberg et al 19 Ramm et al 48 Oriowo et al 22 Srećković et al 52 Ozdamar et al 24 Wang et al 57 Briggs et al 26 Kim and Kim 58 Sanchis-Gimeno et al 27 Altay et al 30 Çolak et al 49 Suraida et al 53 Xiao et al 55 CCT, central corneal thickness. support the theory that DM duration predisposes factors in CCT and ECD alterations.…”

“…There are some studies that have studied the CCT values on different degrees of retinopathy. 53,56 Thus, Wang et al 57 investigated the association between ocular parameters and DR in Chinese people with Type-2 DM. The authors showed that CCT was positively correlated with HbA1c levels; however, no significant correlation was found between CCT and DR.…”