Association between Omentin-1 and Coronary Artery Disease: Pathogenesis and Clinical Research

Abstract

: Like other adipokines, omentin-1 is secreted from visceral adipose tissue and plays a vital role in the development of chronic inflammatory diseases, including cardiovascular events. Recent studies have shown that circulating omentin-1 levels are associated with various metabolic risk factors, such as high blood pressure, increased waist circumference, dyslipidemia, and glucose intolerance. The decrease in serum omentin level is an independent predictor of coronary artery disease (CAD) and is associated with the severity of this disease. Since there is no relevant review in the literature, we aimed to summarize the studies on the relationship between omentin-1 and CAD.

Study of Omentin-1 and Chemerin as Predictors of Coronary Artery Disease in Elderly Patients, with Retrospective Studying of their Relation to Diabetes Mellitus Type 2

“…Omentin-1 may be protective and proinflammatory cytokines. Additionally, omentin-1 may be related to lipid metabolism (6,11,13) . But Shazia et al (28) said "ACS has no association with LDL-C and T Chol levels".…”

“…Stejskal et al (30) stated that omentin-1 seems to be a useful biomarker of coronary artery disease across the whole age spectrum. Omentin-1 might be involved in the development of CAD via dysfunction of endothelium dependent coronary dilatation, insulin activity and inflammation (6) .…”

“…Omentin-1, is an adipokine, increases sensitivity to insulin, its decreased levels may be responsible for impaired glucose homeostasis. Omentin-1 inhibits TNF-induced inflammation of vascular smooth muscle cells, so its decreased levels in plasma of patients with CAD, indicated that omentin-1 may also be involved in the occurrence of ACS (5,6) .…”

The Role of KLF2 in the Regulation of Atherosclerosis Development and Potential Use of KLF2-Targeted Therapy

“…In addition, Omentin-1 activates the Akt signaling pathway, thus, regulating downstream glucose metabolism and could be beneficial for enhancing insulin-stimulated glucose uptake; decreased serum omentin-1 is also associated with inflammatory bowel disease [ 39 ]. Importantly, omentin-1 has been shown to act against atherosclerosis and ischemia-induced revascularization, improve heart damage and functions after reperfusion therapy in patients with acute myocardial infarction, ameliorate acute ischemic injury and stroke, attenuated neointimal formation after arterial injury, and suppressed vascular smooth muscle cells [ 40 , 41 ].…”

Association Between Coronary Artery Disease and Plasma Omentin-1 Levels

“…In his study, Saely et al state that patients within the high omentin group reported significantly more cardiovascular events than patients in the low omentin group [7]. Askin et al stated that a decrease in the omentin levels is an important predictor of CAD and its severity [8]. Zhou et al also found a correlation between higher plasma omentin-1 level and better coronary collateral circulation development [9].…”