Association between osteoporotic fractures and quality of life based on the Korean Community Health Survey of 2010

Jun, Hyun-Ju; Kim, Ki-Jong; Lee, Jinsu; Yang, Sueng-Hoon

doi:10.1589/jpts.27.3325

Cited by 8 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Korea, although researches on HQROL associated with various other diseases are available,[18192021] those related to osteoporosis and osteoporotic fractures are few. [1819] Therefore, we designed to explore HRQOL among Korean patients with osteoporosis and to measure the impact of fractures and comorbidity on their QOL using the Korean National Health and Nutrition Examination Survey (KNHANES) data with a nationwide representativeness.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Health-related Quality of Life in Accordance with Fracture History and Comorbidities in Korean Patients with Osteoporosis

Kwon

Yoo

2016

J Bone Metab

View full text Add to dashboard Cite

BackgroundThe purpose of this study was to explore health-related quality of life (HRQOL) among Korean patients with osteoporosis and to measure the impact of fractures and comorbidity on their quality of life (QOL) using the Korean National Health and Nutrition Examination Survey (KNHANES) data with a nationwide representativeness.MethodsThis study was based on 4-year-data obtained from the KNHANES 2008 to 2011. Osteoporosis was diagnosed in 2,078 survey participants according to their bone mineral density measurements using dual energy X-ray absorptiometry. According to the World Health Organization study group, T-scores at or above -1.0 are considered normal, those between -1.0 and -2.5 as osteopenia, and those at or below -2.5 as osteoporosis The EuroQol five-dimensional questionnaire (EQ-5D) index score was used to assess the QOL.ResultsOf 2,078 patients diagnosed with osteoporosis, fractures were found to occur at 11.02%. Wrist fracture was the most frequent, affecting 4.52% of the patients, with a significantly different prevalence among men and women (P<0.001). The overall EQ-5D index score was 0.84±0.01 among patients with osteoporosis. With the exception of cancer, the EQ-5D index score were significantly lower for those having osteoarthritis, rheumatoid arthritis, hypertension, diabetes, chronic obstructive pulmonary disease and cardiovascular events compared to those without the related diseases.ConclusionsWe found that low health utility was associated with previous spine fracture and comorbidities in patients with osteoporosis. In particular, the number of fracture experiences greatly deteriorated the HRQOL in patients with osteoporosis. Thus, prevention of secondary fractures and chronic care model for comorbidities should be a priority for osteoporosis management in order to improve HRQOL.

show abstract

Section: Introductionmentioning

confidence: 99%

“…[1819] Therefore, we designed to explore HRQOL among Korean patients with osteoporosis and to measure the impact of fractures and comorbidity on their QOL using the Korean National Health and Nutrition Examination Survey (KNHANES) data with a nationwide representativeness.…”

Section: Introductionmentioning

confidence: 99%

Health-related Quality of Life in Accordance with Fracture History and Comorbidities in Korean Patients with Osteoporosis

Kwon

Yoo

2016

J Bone Metab

View full text Add to dashboard Cite

show abstract

“…Reduced HRQoL in patients with osteoporosis is caused primarily by fractures, particularly of the spine or hip, which cause pain and impair physical, social, and mental function [35][36][37]. Therefore, many HRQoL instruments that measure the effects of osteoporosis focus on vertebral, hip, and other nontraumatic fractures on patient function and psychosocial well-being [38,39], and find poor HRQoL after fractures [22]. However, although the primary O + symptom is fracture, other problems, (e.g., the RIP, education, chronic pain, and cigarette smoking) reduce physical capacity and function, and depression worsens the HRQoL of O + patients [20,40].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, depressed patients have higher predictive risk of hip fracture and high depressive symptomatology remained predictive of higher risk of hip fracture than those with low depressive symptomatology [18]. Furthermore, depression appears to increase comorbid medical conditions, disabilities, and healthcare resource use, and to reduce HRQoL [19].Osteoporosis + (O + ) patients with depression and a low HRQoL have a high risk of poor long-term surgical outcomes [20][21][22]. Most studies of the medical resources used focus on osteoporotic fractures; femoral fractures use the most resources because patients require surgery and hospitalization.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Health-Related Quality of Life and Medical Resource Use in Patients with Osteoporosis and Depression: A Cross-Sectional Analysis from the National Health and Nutrition Examination Survey

Weng

Hsu

Weng

et al. 2020

IJERPH

View full text Add to dashboard Cite

Background: Patients with either osteoporosis or depression are prone to develop other diseases and require more medical resources than do the general population. However, there are no studies on health-related quality of life (HRQoL) and medical resource use by osteoporosis patients with comorbid depression. We conducted this study for clarifying it. Methods: This cross-sectional study from 2005 to 2010 (6 years) analyzed 9776 National Health and Nutrition Examination Survey (NHANES) patients > 40 years old. Each patient was assigned to one of four groups: osteoporosis-positive (+) and depression-positive (+) We used multivariate linear and logistic regression model to analyze the HRQoL and medical resource use between groups. Results: The O + /D + group reported more unhealthy days of physical health, more unhealthy days of mental health, and more inactive days during a specified 30 days. The adjusted odds ratios (AORs) of O + /D + patients who had poor general health (7.40, 95% CI = 4.80-11.40), who needed healthcare (3.25, 95% CI = 2.12-5.00), and who had been hospitalized overnight (2.71, 95% CI = 1.89-3.90) were significantly highest. Conclusions: Low HRQoL was significantly more prevalent in D + /O + patients. We found that depression severity more significantly affected HRQoL than did osteoporosis. However, both diseases significantly increased the risk of high medical resource use. expected to increase in the near future. In the developing world, 2% to 8% of men and 9% to 38% of women had osteoporosis [4].An association between major depressive disorder (MDD) and osteoporosis has been reported: patients with MDD apparently have significantly lower bone mineral density (BMD) [5]. Possible factors of reduced BMD in depression patients are the hypothalamic-pituitary-adrenal (HPA) axis: cortisol, leptin, and immune factor levels; cytokine, vitamin D, and parathyroid hormone levels; gender, lifestyle factors, the effect of antidepressants on BMD, osteoporotic fractures, and other comorbid psychiatric conditions [6]. Depression may increase serum cortisol level via activating the hypothalamic corticotropin-releasing hormone neuron. Hypercortisolemia is considered to be a destructive factor for bone health [6]. Depressed patients may have elevated leptin levels, which cause bone loss and inhibits bone formation via activation of sympathetic systems [7,8]. Depression is associated with immune dysregulation and increased oxidative stress, which stimulates HPA axis and results in hypercortisolemia [9,10]. Besides, depression is associated with lower vitamin D and increased parathyroid hormone levels, which may impact bone remodeling [11]. Antidepressants may interfere with sex hormone production such as androgen, which may decrease bone mass and increase risk of orthostatic hypotension, falls and bone fractures [12][13][14]. The incidence rate of depression or anxiety in women with osteoporosis was 46.8 per 1000 person years in the USA [15]. One study utilized data from US households civilian population from 2007...

show abstract

Health-related quality of life of patients with a recent fracture attending a fracture liaison service: a 3-year follow-up study

Oostwaard

Bergh

et al. 2021

Osteoporos Int

View full text Add to dashboard Cite

This study explored the course of health state utility value over 3 years in patients with a recent fracture attending a Fracture Liaison Service and suggested that the overall change in health-related quality of life was not significant, although significant improvements were observed at 6 and 12 months compared to baseline. Introduction To estimate the 3-year health-related quality of life (HRQoL) of patients with a recent fracture presenting at a Fracture Liaison Service (FLS) and to explore factors associated with health state utility value (HSUV). Methods Patients' HSUVs were derived from the EQ-5D-5L and SF-6D and calculated at six time points. Multiple imputation was applied for missing data. Linear mixed-effects regression analysis with random intercept and slope was applied to explore the course of HSUV over 3 years. The impact of subsequent fracture and the length of time between FLS visit and patients' index fracture on HSUV were also investigated. A backward stepwise elimination was applied to identify factors associated with HSUV. Results A total of 499 patients were included. The change of EQ-5D HSUV was not significant over 3-year follow-up (P = 0.52), although slightly but significantly higher HSUV was captured at 6 months (mean difference (MD): 0.015, P = 0.02) and 12 months (MD: 0.018, P = 0.01). There was no significant difference in the course of EQ-5D HSUV between fracture locations (P = 0.86). A significant increase in HSUV was only captured for patients had shorter time period (< 107 days) between FLS visit and their index fracture. Suffering a subsequent fracture was associated with significant QoL loss (MD: − 0.078, P < 0.001). Subsequent fracture, previous treatment with anti-osteoporosis medication, a prevalent vertebral fracture (grade 2 or 3), use of a walking aid, previous falls, and higher BMI were negatively associated with mean EQ-5D HSUV over 3 years. Comparable results were found using SF-6D HSUV. The lack of HRQoL data immediately after fracture and selection bias were two main limitations. Conclusion The 3-year change in HSUV was not statistically significant, although significant improvements were observed at 6 and 12 months in comparison with baseline. Six factors were negatively associated with EQ-5D HSUV.

show abstract

Association between osteoporotic fractures and quality of life based on the Korean Community Health Survey of 2010

Cited by 8 publications

References 15 publications

Health-related Quality of Life in Accordance with Fracture History and Comorbidities in Korean Patients with Osteoporosis

Health-related Quality of Life in Accordance with Fracture History and Comorbidities in Korean Patients with Osteoporosis

Health-Related Quality of Life and Medical Resource Use in Patients with Osteoporosis and Depression: A Cross-Sectional Analysis from the National Health and Nutrition Examination Survey

Health-related quality of life of patients with a recent fracture attending a fracture liaison service: a 3-year follow-up study

Contact Info

Product

Resources

About